ID Q846X0_STRVG Unreviewed; 980 AA. AC Q846X0; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 27-MAR-2024, entry version 112. DE SubName: Full=MonH {ECO:0000313|EMBL:ANZ52465.1}; DE SubName: Full=Putative regulatory protein {ECO:0000313|EMBL:AAO65802.1}; GN Name=monH {ECO:0000313|EMBL:AAO65802.1}; OS Streptomyces virginiae (Streptomyces cinnamonensis). OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; OC Streptomycetaceae; Streptomyces. OX NCBI_TaxID=1961 {ECO:0000313|EMBL:AAO65802.1}; RN [1] {ECO:0000313|EMBL:AAO65802.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ATCC15413 {ECO:0000313|EMBL:AAO65802.1}; RA Oliynyk M.; RT "The gene cluster for monensin biosynthesis."; RL Thesis (1999), University of Cambridge. RN [2] {ECO:0000313|EMBL:AAO65802.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ATCC15413 {ECO:0000313|EMBL:AAO65802.1}; RX PubMed=12940979; DOI=10.1046/j.1365-2958.2003.03571.x; RA Oliynyk M., Stark C.B., Bhatt A., Jones M.A., Hughes-Thomas Z.A., RA Wilkinson C., Oliynyk Z., Demydchuk Y., Staunton J., Leadlay P.F.; RT "Analysis of the biosynthetic gene cluster for the polyether antibiotic RT monensin in Streptomyces cinnamonensis and evidence for the role of monB RT and monC genes in oxidative cyclization."; RL Mol. Microbiol. 49:1179-1190(2003). RN [3] {ECO:0000313|EMBL:ANZ52465.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=ST021 {ECO:0000313|EMBL:ANZ52465.1}; RX PubMed=27718094; RA Zhang Y., Lin C.Y., Li X.M., Tang Z.K., Qiao J., Zhao G.R.; RT "DasR positively controls monensin production at two-level regulation in RT Streptomyces cinnamonensis."; RL J. Ind. Microbiol. Biotechnol. 0:0-0(2016). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF440781; AAO65802.1; -; Genomic_DNA. DR EMBL; KX263301; ANZ52465.1; -; Genomic_DNA. DR AlphaFoldDB; Q846X0; -. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd06170; LuxR_C_like; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR041664; AAA_16. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor. DR InterPro; IPR000792; Tscrpt_reg_LuxR_C. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1. DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1. DR Pfam; PF13191; AAA_16; 1. DR Pfam; PF00196; GerE; 1. DR PRINTS; PR00038; HTHLUXR. DR SMART; SM00382; AAA; 1. DR SMART; SM00421; HTH_LUXR; 1. DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00622; HTH_LUXR_1; 1. DR PROSITE; PS50043; HTH_LUXR_2; 1. PE 4: Predicted; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}. FT DOMAIN 919..980 FT /note="HTH luxR-type" FT /evidence="ECO:0000259|PROSITE:PS50043" FT REGION 119..154 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 484..519 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 902..926 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 124..152 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 504..519 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 980 AA; 102699 MW; 5070C3E097FFC735 CRC64; MSGVERGVGS AGPVEQGDGL AGLVERAEAL AALRGAFDGS PGTGGSLVVL SGAVGTGKTA LLRAWADRIG ADADALVLTA TACRAERDLP LGVLEQLVRS PGLPPASAER ALAWWDEEAS ATPGKTDANG TSANGTDANG TGAGQTGAGQ AGVGQTGVGG EPVLAASALR GLCEVLRDLL AERPVVVAVD DAHHADAASL QCLLSVVRRL RSARLHVLFT EYAHQKAQNA LLSSEFLHEP ALRRIRLEPL SKAGVEALLA RHLDERTAQD LTPVVHGMSA GHPLLVRALA EDHRAAGGAG EAYGRAVLSF LYRHETPVTQ VARAIAALGA HAGPGQVGRL LDVDAASVER AVRQLTVAEV LHEGRLCHPA FAAAVLDGMP PEERRALHGR VADLLHEEGA PATEVAAHLV AADRSDAPWA VPVFQEAAQL ALDEDQVETG VDYLRAAHQR CRGAAQRAAV VGALADAEWR LDPAKVLRHL PDPAAMAPQT DPAALAPHTD PAPTAAPTAA PTPTPIPTTP PLPTHLLWHG RVEEGLDAIG TLTGPGPNPA GAPPMNPADL DTPWLWGAYL YPGHVKERLG SGALSPQRST PPAVTPELQG AGTLMNDLLH GGERDATEAA ERALNRYRLG PRTIAVQTAA LAALTYRDRP HRAAAWCDGL VAQADERNSP TWRALFTAWR ALLHLRQGDP AAAEQRAETA LALLGSKGWG AAIGLPLAAA VQAKAALGDV DGAAALLERP VPQAVFQTRT GLHYLAARGR YHLATGCHYA ALCDFYACGT RMSSWGVDLP ALEPWRLGAA EAYLALGEGL LARQLVDGQL PLPTPDDGRT WGMTLRLRAA TSPAPARAEL LDEAVAVLRE SGDTFELARA VADQAVAVRE GGEAERARLL ARKAELLARR WGSAPAPATV PEPPERPGPA TPDAELTSAE RRVAELAAEG FTNREISRKL CVTVSTVEQH LTRIYRKLDV RRLDLQAALG //