ID Q83625_9PARA PRELIMINARY; PRT; 617 AA. AC Q83625; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-FEB-2005 (TrEMBLrel. 29, Last annotation update) DE Hemagglutinin protein. GN Name=H; OS Measles virus. OC Viruses; ssRNA negative-strand viruses; Mononegavirales; OC Paramyxoviridae; Paramyxovirinae; Morbillivirus. OX NCBI_TaxID=11234; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Edmonston B; RX MEDLINE=90151611; PubMed=2303032; RA Ballart I., Eschle D., Cattaneo R., Schmid A., Metzler M., Chan J., RA Pifko-Hirst S., Udem S.A., Billeter M.A.; RT "Infectious measles virus from cloned cDNA."; RL EMBO J. 9:379-384(1990). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Edmonston B; RX MEDLINE=96112793; PubMed=8846771; RA Radecke F., Spielhofer P., Schneider H., Kaelin K., Huber M., RA Doetsch C., Christiansen G., Billeter M.A.; RT "Rescue of measles viruses from cloned DNA."; RL EMBO J. 14:5773-5784(1995). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Edmonston B; RA Billeter M.M.; RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RA Santibanez S., Niewiesk S., Hengel H.; RT "Probing neutralizing antibody responses against emerging measles RT viruses (MV): Immune selection of MV by H protein-specific RT antibodies?"; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Leningrad-4; RA Zhao D.; RT "The whole gene sequence of Measles virus."; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Hemagglutinin is responsible for attaching the virus to CC cell receptors and for initiating infection. Neuraminidase CC activity helps the efficient spread of the virus by dissociating CC the mature virions from the neuraminic acid containing CC glycoproteins (By similarity). CC -!- CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, CC alpha-(2->8)-glycosidic linkages of terminal sialic residues in CC oligosaccharides, glycoproteins, glycolipids, colominic acid and CC synthetic substrates. CC -!- SUBCELLULAR LOCATION: External, anchored to the envelope by its N- CC terminal hydrophobic sequence (By similarity). CC -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin- CC neuraminidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z66517; CAA91369.1; -. DR EMBL; AY685221; AAT99297.1; -. DR EMBL; AY730614; AAV84958.1; -. DR PIR; PQ0377; PQ0377. DR PIR; PQ0381; PQ0381. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0019031; C:viral envelope; IEA. DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA. DR GO; GO:0016787; F:hydrolase activity; IEA. DR GO; GO:0019058; P:viral infectious cycle; IEA. DR InterPro; IPR000665; Hem-neuramndse. DR Pfam; PF00423; HN; 1. KW Envelope protein; Hemagglutinin; Hydrolase; Transmembrane. SQ SEQUENCE 617 AA; 69219 MW; 0E45DF3EDA43D9C6 CRC64; MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSLT VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP YLFNVPIKEA GEDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGMV GMGVSCTVTR EDGTNRR //