ID Q83625_9MONO Unreviewed; 617 AA.
AC Q83625;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 29-MAY-2024, entry version 132.
DE RecName: Full=Hemagglutinin glycoprotein {ECO:0000256|ARBA:ARBA00020483};
GN Name=H {ECO:0000313|EMBL:AAT99297.1};
OS Measles morbillivirus.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Morbillivirus; Morbillivirus hominis.
OX NCBI_TaxID=11234 {ECO:0000313|EMBL:CAA91369.1, ECO:0000313|Proteomes:UP000100252};
RN [1] {ECO:0000313|EMBL:CAA91369.1, ECO:0000313|Proteomes:UP000100252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edmonston B {ECO:0000313|EMBL:CAA91369.1};
RX PubMed=2303032;
RA Ballart I., Eschle D., Cattaneo R., Schmid A., Metzler M., Chan J.,
RA Pifko-Hirst S., Udem S.A., Billeter M.A.;
RT "Infectious measles virus from cloned cDNA.";
RL EMBO J. 9:379-384(1990).
RN [2] {ECO:0000313|EMBL:CAA91369.1, ECO:0000313|Proteomes:UP000100252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edmonston B {ECO:0000313|EMBL:CAA91369.1};
RX PubMed=8846771;
RA Radecke F., Spielhofer P., Schneider H., Kaelin K., Huber M., Doetsch C.,
RA Christiansen G., Billeter M.A.;
RT "Rescue of measles viruses from cloned DNA.";
RL EMBO J. 14:5773-5784(1995).
RN [3] {ECO:0000313|Proteomes:UP000100252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7747453; DOI=10.1006/viro.1995.1214;
RA Komase K., Rima B., Pardowitz I., Kunz C., Billeter M.A., ter Meulen V.,
RA Baczko K.;
RT "A comparison of nucleotide sequences of measles virus L genes derived from
RT wild-type viruses and SSPE brain tissues.";
RL Virology 208:795-799(1995).
RN [4] {ECO:0000313|EMBL:CAA91369.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Edmonston B {ECO:0000313|EMBL:CAA91369.1};
RA Billeter M.M.;
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAV84958.1, ECO:0000313|Proteomes:UP000131292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leningrad-4 {ECO:0000313|EMBL:AAV84958.1};
RA Zhao D.;
RT "The whole gene sequence of Measles virus.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAT99297.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MVi/Prague.CZH/Havlowa.1/60 {ECO:0000313|EMBL:AAT99297.1};
RX PubMed=15659756; DOI=10.1099/vir.0.80467-0;
RA Santibanez S., Niewiesk S., Heider A., Schneider-Schaulies J.,
RA Berbers G.A., Zimmermann A., Halenius A., Wolbert A., Deitemeier I.,
RA Tischer A., Hengel H.;
RT "Probing neutralizing-antibody responses against emerging measles viruses
RT (MVs): immune selection of MV by H protein-specific antibodies?";
RL J. Gen. Virol. 86:365-374(2005).
CC -!- FUNCTION: Attaches the virus to cell receptors and thereby initiating
CC infection. Binding of H protein to the receptor induces a
CC conformational change that allows the F protein to trigger virion/cell
CC membranes fusion. May use human CD46 and/or SLAMF1 as receptors for
CC viral entry into the cell. The high degree of interaction between H and
CC MCP/CD46 results in down-regulation of the latter from the surface of
CC infected cells, rendering them more sensitive to c3b-mediated
CC complement lysis. {ECO:0000256|ARBA:ARBA00037156}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. Virion
CC membrane {ECO:0000256|ARBA:ARBA00004208}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004208}.
CC -!- SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase
CC family. Non-sialidase subfamily. {ECO:0000256|ARBA:ARBA00006578}.
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DR EMBL; AY685221; AAT99297.1; -; Genomic_RNA.
DR EMBL; AY730614; AAV84958.1; -; Genomic_RNA.
DR EMBL; Z66517; CAA91369.1; -; Genomic_RNA.
DR PIR; PQ0377; PQ0377.
DR PIR; PQ0381; PQ0381.
DR Proteomes; UP000100252; Genome.
DR Proteomes; UP000131292; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0046718; P:symbiont entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd15467; MV-h; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR InterPro; IPR000665; Hemagglutn/HN.
DR InterPro; IPR049617; MV-h_C.
DR InterPro; IPR036278; Sialidase_sf.
DR Pfam; PF00423; HN; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemagglutinin {ECO:0000256|ARBA:ARBA00022546,
KW ECO:0000256|RuleBase:RU004216};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879,
KW ECO:0000256|RuleBase:RU004216};
KW Virion {ECO:0000256|ARBA:ARBA00022879, ECO:0000256|RuleBase:RU004216};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 617 AA; 69220 MW; 0E45DF3EDA43D9C6 CRC64;
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI GLLAIAGIRL
HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG DEVGLRTPQR FTDLVKFISD
KIKFLNPDRE YDFRDLTWCI NPPERIKLDY DQYCADVAAE ELMNALVNST LLETRTTNQF
LAVSKGNCSG PTTIRGQFSN MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS
SKRSELSQLS MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC
HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY LSSHRGVIAD
NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA PLKDNRIPSY GVLSVDLSLT
VELKIKIASG FGPLITHGSG MDLYKSNHNN VYWLTIPPMK NLALGVINTL EWIPRFKVSP
YLFNVPIKEA GEDCHAPTYL PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY
YVYSPSRSFS YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGMV
GMGVSCTVTR EDGTNRR
//