ID HGD_STRAW STANDARD; PRT; 438 AA. AC Q828S5; DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 21-MAR-2006, entry version 14. DE Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisicase) DE (Homogentisate oxygenase) (Homogentisic acid oxidase). GN Name=hmgA; OrderedLocusNames=SAV6587; OS Streptomyces avermitilis. OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Streptomycineae; Streptomycetaceae; Streptomyces. OX NCBI_TaxID=33903; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MA-4680 / ATCC 31267 / NCIMB 12804 / NRRL 8165; RX MEDLINE=21477403; PubMed=11572948; DOI=10.1073/pnas.211433198; RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., RA Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., RA Kikuchi H., Shiba T., Sakaki Y., Hattori M.; RT "Genome sequence of an industrial microorganism Streptomyces RT avermitilis: deducing the ability of producing secondary RT metabolites."; RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MA-4680 / ATCC 31267 / NCIMB 12804 / NRRL 8165; RX MEDLINE=22608306; PubMed=12692562; DOI=10.1038/nbt820; RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., RA Sakaki Y., Hattori M., Omura S.; RT "Complete genome sequence and comparative analysis of the industrial RT microorganism Streptomyces avermitilis."; RL Nat. Biotechnol. 21:526-531(2003). CC -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate. CC -!- COFACTOR: Iron (By similarity). CC -!- PATHWAY: Catabolism of tyrosine; third step. CC -!- PATHWAY: Catabolism of phenylalanine; fourth step. CC -!- SIMILARITY: Belongs to the homogentisate dioxygenase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000030; BAC74298.1; -; Genomic_DNA. DR GenomeReviews; BA000030_GR; SAV6587. DR BioCyc; SAVE-XXX-01:SAVE-XXX-01-006685-MONOMER; -. DR BioCyc; SAVE227882:SAV6587-MONOMER; -. DR HAMAP; MF_00334; -; 1. DR InterPro; IPR011051; Cupin_RmlC_type. DR InterPro; IPR005708; Homogentis_dOase. DR Pfam; PF04209; HgmA; 1. DR TIGRFAMs; TIGR01015; hmgA; 1. KW Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; KW Phenylalanine catabolism; Tyrosine catabolism. FT CHAIN 1 438 Homogentisate 1,2-dioxygenase. FT /FTId=PRO_0000220255. FT METAL 337 337 Iron (By similarity). FT METAL 343 343 Iron (By similarity). FT METAL 373 373 Iron (By similarity). SQ SEQUENCE 438 AA; 47823 MW; 8E751EBA9B6F53BC CRC64; MSGDARKTAE GLAHLTGFGN EHASEAVPGA LPEGRNSPQR APLGLYAEQL SGSAFTEPRA HNRRSWLYRI RPSAAHPPFT RADNGAIRTA PFTETAPDPN RLRWNPLPEP PAGTDFVGGL WTLGGNGDAT QRTGMAVHLY HANSSMDRVF SDADGELLIV PERGGLLLRT EFGLLHAEPG QVALVPRGVR FRVDLLDESA RGYVCENYGA PFQLPDLGPI GANGLAAARD FKAPVAAYED VEGPVEVVNK FCGNLWTATY DHSPLDVVAW HGNHVPYTYD LRRFNVLGTI SYDHPDPSIF TVLTSPSDTP GLAGVDFVVF APRWLVGEDT FRPPYFHRNV MSEYMGLIEG AYDAKAAGFV PGGGSLHNMM SAHGPDRETF DRASAAELRP QKIDDGLAFM FETRWPVTAT AQAARAEHLQ PAYDDVWQGL QRHFRPSD //