ID NOC_BACCR Reviewed; 290 AA. AC Q814F9; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 18-APR-2012, entry version 49. DE RecName: Full=Nucleoid occlusion protein; DE Short=Noc; GN Name=noc; OrderedLocusNames=BC_5483; OS Bacillus cereus (strain ATCC 14579 / DSM 31). OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; OC Bacillus cereus group. OX NCBI_TaxID=226900; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 14579 / DSM 31; RX MEDLINE=22608415; PubMed=12721630; DOI=10.1038/nature01582; RA Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., RA Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., RA Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., RA Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., RA Overbeek R., Kyrpides N.C.; RT "Genome sequence of Bacillus cereus and comparative analysis with RT Bacillus anthracis."; RL Nature 423:87-91(2003). CC -!- FUNCTION: Effects nucleoid occlusion by binding relatively CC nonspecifically to DNA and preventing the assembly of the division CC machinery in the vicinity of the nucleoid, especially under CC conditions that disturb the cell cycle. It helps to coordinate CC cell division and chromosome segregation by preventing the CC formation of the Z ring through the nucleoid, which would cause CC chromosome breakage (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity). CC -!- SIMILARITY: Belongs to the parB family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016877; AAP12337.1; -; Genomic_DNA. DR RefSeq; NP_835136.1; NC_004722.1. DR ProteinModelPortal; Q814F9; -. DR STRING; Q814F9; -. DR EnsemblBacteria; EBBACT00000031475; EBBACP00000030681; EBBACG00000031466. DR GeneID; 1207822; -. DR GenomeReviews; AE016877_GR; BC_5483. DR KEGG; bce:BC5483; -. DR PATRIC; 32607188; VBIBacCer54481_5661. DR eggNOG; COG1475; -. DR HOGENOM; HBG641230; -. DR KO; K03497; -. DR OMA; RFQPRTI; -. DR ProtClustDB; CLSK873785; -. DR BioCyc; BCER226900:BC_5483-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR Gene3D; G3DSA:1.10.260.40; G3DSA:1.10.260.40; 1. DR HAMAP; MF_02015; ParB_Noc; 1; -. DR InterPro; IPR010982; Lambda_DNA-bd. DR InterPro; IPR023705; Nucleoid_occlusion_protein. DR InterPro; IPR004437; ParB_part. DR InterPro; IPR003115; ParBc. DR Pfam; PF02195; ParBc; 1. DR SMART; SM00470; ParB; 1. DR SUPFAM; SSF110849; ParBc; 1. DR TIGRFAMs; TIGR00180; ParB_part; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Complete proteome; Cytoplasm; DNA-binding; KW Reference proteome; Septation. FT CHAIN 1 290 Nucleoid occlusion protein. FT /FTId=PRO_0000346619. FT DNA_BIND 153 172 H-T-H motif (Potential). SQ SEQUENCE 290 AA; 33618 MW; B3DE34F7E3F0390B CRC64; MKNTFSRLFG FGDKESEFEL QDESHEEIDK KVYEEIQEIP IVNITPNRYQ PRTVFDDARI DELALTIRTH GLIQPIVVRQ YEDDKYEIIA GERRFRAATK LGWEKVPAII KNLNDTETAS VALIENLQRE ELTAIEEAVA YQKLIELHNL TQEALAQRLG KGQSTIANKL RLLKLPEEIK SALLEKSITE RHARALIPLK NEELQLKVLQ EIVEKQLNVK QTEERIAKLL EEAKPKRKAK QKAVSRDTRI AMNTIRQSLQ MVTESGLNVN SEEEEFDEYY QITIKIPKKK //