ID NOC_BACCR Reviewed; 290 AA. AC Q814F9; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 24-JAN-2024, entry version 104. DE RecName: Full=Nucleoid occlusion protein {ECO:0000255|HAMAP-Rule:MF_02015}; DE Short=Noc {ECO:0000255|HAMAP-Rule:MF_02015}; GN Name=noc {ECO:0000255|HAMAP-Rule:MF_02015}; OrderedLocusNames=BC_5483; OS Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC OS 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711). OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus; OC Bacillus cereus group. OX NCBI_TaxID=226900; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 RC / NCTC 2599 / NRRL B-3711; RX PubMed=12721630; DOI=10.1038/nature01582; RA Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., RA Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., RA Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., RA Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.; RT "Genome sequence of Bacillus cereus and comparative analysis with Bacillus RT anthracis."; RL Nature 423:87-91(2003). CC -!- FUNCTION: Effects nucleoid occlusion by binding relatively CC nonspecifically to DNA and preventing the assembly of the division CC machinery in the vicinity of the nucleoid, especially under conditions CC that disturb the cell cycle. It helps to coordinate cell division and CC chromosome segregation by preventing the formation of the Z ring CC through the nucleoid, which would cause chromosome breakage. CC {ECO:0000255|HAMAP-Rule:MF_02015}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP- CC Rule:MF_02015}. CC -!- SIMILARITY: Belongs to the ParB family. {ECO:0000255|HAMAP- CC Rule:MF_02015}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE016877; AAP12337.1; -; Genomic_DNA. DR RefSeq; NP_835136.1; NC_004722.1. DR RefSeq; WP_000799016.1; NZ_CP034551.1. DR AlphaFoldDB; Q814F9; -. DR SMR; Q814F9; -. DR STRING; 226900.BC_5483; -. DR GeneID; 72452131; -. DR KEGG; bce:BC5483; -. DR PATRIC; fig|226900.8.peg.5661; -. DR HOGENOM; CLU_023853_0_1_9; -. DR OMA; YQPRTIF; -. DR OrthoDB; 9802051at2; -. DR Proteomes; UP000001417; Chromosome. DR GO; GO:0005694; C:chromosome; IBA:GO_Central. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule. DR GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central. DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW. DR GO; GO:0045881; P:positive regulation of sporulation resulting in formation of a cellular spore; IBA:GO_Central. DR CDD; cd16393; SPO0J_N; 1. DR Gene3D; 1.10.10.2830; -; 1. DR Gene3D; 3.90.1530.30; -; 1. DR HAMAP; MF_02015; ParB_Noc; 1. DR InterPro; IPR041468; HTH_ParB/Spo0J. DR InterPro; IPR023705; Nucleoid_occlusion_protein. DR InterPro; IPR004437; ParB/RepB/Spo0J. DR InterPro; IPR003115; ParB/Sulfiredoxin_dom. DR InterPro; IPR036086; ParB/Sulfiredoxin_sf. DR NCBIfam; TIGR04285; nucleoid_noc; 1. DR NCBIfam; TIGR00180; parB_part; 1. DR PANTHER; PTHR33375; CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED; 1. DR PANTHER; PTHR33375:SF8; NUCLEOID OCCLUSION PROTEIN; 1. DR Pfam; PF17762; HTH_ParB; 1. DR Pfam; PF02195; ParBc; 1. DR SMART; SM00470; ParB; 1. DR SUPFAM; SSF110849; ParB/Sulfiredoxin; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Cytoplasm; DNA-binding; Reference proteome; KW Septation. FT CHAIN 1..290 FT /note="Nucleoid occlusion protein" FT /id="PRO_0000346619" FT DNA_BIND 153..172 FT /note="H-T-H motif" FT /evidence="ECO:0000255|HAMAP-Rule:MF_02015" SQ SEQUENCE 290 AA; 33618 MW; B3DE34F7E3F0390B CRC64; MKNTFSRLFG FGDKESEFEL QDESHEEIDK KVYEEIQEIP IVNITPNRYQ PRTVFDDARI DELALTIRTH GLIQPIVVRQ YEDDKYEIIA GERRFRAATK LGWEKVPAII KNLNDTETAS VALIENLQRE ELTAIEEAVA YQKLIELHNL TQEALAQRLG KGQSTIANKL RLLKLPEEIK SALLEKSITE RHARALIPLK NEELQLKVLQ EIVEKQLNVK QTEERIAKLL EEAKPKRKAK QKAVSRDTRI AMNTIRQSLQ MVTESGLNVN SEEEEFDEYY QITIKIPKKK //