ID Q81275_9HEPC Unreviewed; 178 AA. AC Q81275; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 19-JAN-2022, entry version 56. DE SubName: Full=Core protein {ECO:0000313|EMBL:AAA45536.1}; DE Flags: Fragment; OS Hepacivirus C. OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; OC Amarillovirales; Flaviviridae; Hepacivirus. OX NCBI_TaxID=11103 {ECO:0000313|EMBL:AAA45536.1}; RN [1] {ECO:0000313|EMBL:AAA45536.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=1653756; DOI=10.1016/0378-1119(91)90269-H; RA Fuchs K., Motz M., Schreier E., Zachoval R., Deinhardt F., Roggendorf M.; RT "Characterization of nucleotide sequences from European hepatitis C virus RT isolates."; RL Gene 103:163-169(1991). CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M61719; AAA45536.1; -; Genomic_RNA. DR PIR; PS0388; PS0388. DR euHCVdb; M61719; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0019028; C:viral capsid; IEA:InterPro. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR Gene3D; 4.10.710.10; -; 1. DR InterPro; IPR002521; HCV_core_C. DR InterPro; IPR044896; HCV_core_chain_A. DR InterPro; IPR002522; HCV_core_N. DR Pfam; PF01543; HCV_capsid; 1. DR Pfam; PF01542; HCV_core; 1. PE 4: Predicted; KW Fusion of virus membrane with host membrane KW {ECO:0000256|ARBA:ARBA00022506}; KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022506}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00022506}. FT DOMAIN 1..109 FT /note="HCV_capsid" FT /evidence="ECO:0000259|Pfam:PF01543" FT DOMAIN 110..178 FT /note="HCV_core" FT /evidence="ECO:0000259|Pfam:PF01542" FT REGION 1..70 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 41..63 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAA45536.1" FT NON_TER 178 FT /evidence="ECO:0000313|EMBL:AAA45536.1" SQ SEQUENCE 178 AA; 19463 MW; 4ABDCD20895FC87F CRC64; PQRKTKRNTN RRPQDVKFPG GGQIVGGVYL LPRRGPRLGV RAPRKTSERS QPRGRRQPIP KARRPEGRTW AQPGYPWPLY GNEGCGWAGW LLSPRGSRPS WGPTDPRRRS RNLGKVIDTL TCGFADLMGY IPLVGAPLGG AARALAHGVR VLEDGVNYAT GNLPGCSFSI FLLALLSC //