ID MPRB_MOUSE Reviewed; 354 AA. AC Q80ZE5; Q3UHI5; Q8C891; Q8CCW9; Q9DA71; DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 16-AUG-2004, sequence version 2. DT 19-MAR-2014, entry version 80. DE RecName: Full=Membrane progestin receptor beta; DE Short=mPR beta; DE AltName: Full=Progestin and adipoQ receptor family member VIII; GN Name=Paqr8; Synonyms=Mprb; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RC STRAIN=CD-1; TISSUE=Testis; RX PubMed=12601167; DOI=10.1073/pnas.0436133100; RA Zhu Y., Bond J., Thomas P.; RT "Identification, classification, and partial characterization of genes RT in humans and other vertebrates homologous to a fish membrane RT progestin receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6J; RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2; RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., RA Funk W.D.; RT "PAQR proteins: a novel membrane receptor family defined by an ancient RT 7-transmembrane pass motif."; RL J. Mol. Evol. 61:372-380(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Head, Medulla oblongata, and Testis; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP TISSUE SPECIFICITY. RX PubMed=11676489; DOI=10.1006/bbrc.2001.5825; RA Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., RA Inazawa J., Delgado-Escueta A.V., Yamakawa K.; RT "A novel gene in the chromosomal region for juvenile myoclonic RT epilepsy on 6p12 encodes a brain-specific lysosomal membrane RT protein."; RL Biochem. Biophys. Res. Commun. 288:626-636(2001). CC -!- FUNCTION: Steroid membrane receptor. Binds progesterone. May be CC involved in oocyte maturation. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein CC (By similarity). CC -!- TISSUE SPECIFICITY: Expressed in brain and testis. CC -!- SIMILARITY: Belongs to the ADIPOR family. CC -!- SEQUENCE CAUTION: CC Sequence=BAC27629.1; Type=Frameshift; Positions=324; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF313617; AAO47230.1; -; mRNA. DR EMBL; AY424297; AAR08385.1; -; mRNA. DR EMBL; AK006107; BAB24412.1; -; mRNA. DR EMBL; AK029772; BAC26609.1; -; mRNA. DR EMBL; AK031969; BAC27629.1; ALT_FRAME; mRNA. DR EMBL; AK048045; BAC33221.1; -; mRNA. DR EMBL; AK147376; BAE27872.1; -; mRNA. DR EMBL; BC059813; AAH59813.1; -; mRNA. DR RefSeq; NP_083105.3; NM_028829.3. DR RefSeq; XP_006495640.1; XM_006495577.1. DR RefSeq; XP_006495641.1; XM_006495578.1. DR UniGene; Mm.40780; -. DR PaxDb; Q80ZE5; -. DR PRIDE; Q80ZE5; -. DR Ensembl; ENSMUST00000068880; ENSMUSP00000069127; ENSMUSG00000025931. DR Ensembl; ENSMUST00000167119; ENSMUSP00000128781; ENSMUSG00000025931. DR GeneID; 74229; -. DR KEGG; mmu:74229; -. DR UCSC; uc007ald.1; mouse. DR CTD; 85315; -. DR MGI; MGI:1921479; Paqr8. DR eggNOG; COG1272; -. DR GeneTree; ENSGT00530000062965; -. DR HOGENOM; HOG000230872; -. DR HOVERGEN; HBG052504; -. DR InParanoid; Q80ZE5; -. DR OMA; REPYIHA; -. DR OrthoDB; EOG7SN8D2; -. DR TreeFam; TF319738; -. DR NextBio; 340170; -. DR PRO; PR:Q80ZE5; -. DR Bgee; Q80ZE5; -. DR CleanEx; MM_PAQR8; -. DR Genevestigator; Q80ZE5; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IBA:RefGenome. DR GO; GO:0005496; F:steroid binding; IBA:RefGenome. DR GO; GO:0003707; F:steroid hormone receptor activity; IBA:RefGenome. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW. DR InterPro; IPR004254; HlyIII-related. DR PANTHER; PTHR20855; PTHR20855; 1. DR Pfam; PF03006; HlyIII; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Developmental protein; KW Differentiation; Lipid-binding; Membrane; Oogenesis; Receptor; KW Reference proteome; Steroid-binding; Transmembrane; KW Transmembrane helix. FT CHAIN 1 354 Membrane progestin receptor beta. FT /FTId=PRO_0000218841. FT TOPO_DOM 1 76 Cytoplasmic (Potential). FT TRANSMEM 77 97 Helical; Name=1; (Potential). FT TOPO_DOM 98 111 Extracellular (Potential). FT TRANSMEM 112 132 Helical; Name=2; (Potential). FT TOPO_DOM 133 173 Cytoplasmic (Potential). FT TRANSMEM 174 194 Helical; Name=3; (Potential). FT TOPO_DOM 195 213 Extracellular (Potential). FT TRANSMEM 214 234 Helical; Name=4; (Potential). FT TOPO_DOM 235 243 Cytoplasmic (Potential). FT TRANSMEM 244 264 Helical; Name=5; (Potential). FT TOPO_DOM 265 283 Extracellular (Potential). FT TRANSMEM 284 304 Helical; Name=6; (Potential). FT TOPO_DOM 305 315 Cytoplasmic (Potential). FT TRANSMEM 316 336 Helical; Name=7; (Potential). FT TOPO_DOM 337 354 Extracellular (Potential). FT CONFLICT 41 41 D -> G (in Ref. 3; AAR08385/BAC33221). FT CONFLICT 116 116 I -> V (in Ref. 1; AAO47230). FT CONFLICT 177 177 I -> L (in Ref. 1; AAO47230). FT CONFLICT 339 339 T -> S (in Ref. 1; AAO47230). SQ SEQUENCE 354 AA; 40430 MW; 14544CBB3338B538 CRC64; MTTAILERLS TLSMSGQQLR RLPKILEEGL PKMPCTVPET DVPQLFREPY IHAGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVEAG ALQWASPHTL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYELFWIFFL PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FVLDISPVAH RVALCHLAGC QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS VCTLSQLEAI LLDYQGRHEI FLQRHGPLSV YSACLSFFVL AACSAATATL LRHKVKDRLI KKDS //