ID MPRB_MOUSE Reviewed; 354 AA. AC Q80ZE5; Q3UHI5; Q8C891; Q8CCW9; Q9DA71; DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 16-AUG-2004, sequence version 2. DT 16-JUN-2009, entry version 47. DE RecName: Full=Membrane progestin receptor beta; DE Short=mPR beta; DE AltName: Full=Progestin and adipoQ receptor family member VIII; GN Name=Paqr8; Synonyms=Mprb; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RC STRAIN=CD-1; TISSUE=Testis; RX MEDLINE=22506359; PubMed=12601167; DOI=10.1073/pnas.0436133100; RA Zhu Y., Bond J., Thomas P.; RT "Identification, classification, and partial characterization of genes RT in humans and other vertebrates homologous to a fish membrane RT progestin receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=C57BL/6J; RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2; RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., RA Funk W.D.; RT "PAQR proteins: a novel membrane receptor family defined by an ancient RT 7-transmembrane pass motif."; RL J. Mol. Evol. 61:372-380(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Head, Medulla oblongata, and Testis; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP TISSUE SPECIFICITY. RX MEDLINE=21534262; PubMed=11676489; DOI=10.1006/bbrc.2001.5825; RA Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., RA Inazawa J., Delgado-Escueta A.V., Yamakawa K.; RT "A novel gene in the chromosomal region for juvenile myoclonic RT epilepsy on 6p12 encodes a brain-specific lysosomal membrane RT protein."; RL Biochem. Biophys. Res. Commun. 288:626-636(2001). CC -!- FUNCTION: Steroid membrane receptor. Binds progesterone. May be CC involved in oocyte maturation. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By CC similarity). CC -!- TISSUE SPECIFICITY: Expressed in brain and testis. CC -!- SIMILARITY: Belongs to the ADIPOR family. CC -!- SEQUENCE CAUTION: CC Sequence=BAC27629.1; Type=Frameshift; Positions=324; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF313617; AAO47230.1; -; mRNA. DR EMBL; AY424297; AAR08385.1; -; mRNA. DR EMBL; AK006107; BAB24412.1; -; mRNA. DR EMBL; AK029772; BAC26609.1; -; mRNA. DR EMBL; AK031969; BAC27629.1; ALT_FRAME; mRNA. DR EMBL; AK048045; BAC33221.1; -; mRNA. DR EMBL; AK147376; BAE27872.1; -; mRNA. DR EMBL; BC059813; AAH59813.1; -; mRNA. DR IPI; IPI00118029; -. DR RefSeq; NP_083105.3; -. DR UniGene; Mm.40780; -. DR PRIDE; Q80ZE5; -. DR Ensembl; ENSMUSG00000025931; Mus musculus. DR GeneID; 74229; -. DR KEGG; mmu:74229; -. DR MGI; MGI:1921479; Paqr8. DR HOGENOM; Q80ZE5; -. DR HOVERGEN; Q80ZE5; -. DR OMA; Q80ZE5; SDQAWYE. DR NextBio; 340170; -. DR ArrayExpress; Q80ZE5; -. DR Bgee; Q80ZE5; -. DR CleanEx; MM_PAQR8; -. DR GermOnline; ENSMUSG00000025931; Mus musculus. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW. DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW. DR InterPro; IPR004254; HlyIII_related. DR PANTHER; PTHR20855; HlyIII_related; 1. DR Pfam; PF03006; HlyIII; 1. PE 2: Evidence at transcript level; KW Lipid-binding; Membrane; Receptor; Steroid-binding; Transmembrane. FT CHAIN 1 354 Membrane progestin receptor beta. FT /FTId=PRO_0000218841. FT TOPO_DOM 1 76 Extracellular (Potential). FT TRANSMEM 77 97 1 (Potential). FT TOPO_DOM 98 111 Cytoplasmic (Potential). FT TRANSMEM 112 132 2 (Potential). FT TOPO_DOM 133 173 Extracellular (Potential). FT TRANSMEM 174 194 3 (Potential). FT TOPO_DOM 195 213 Cytoplasmic (Potential). FT TRANSMEM 214 234 4 (Potential). FT TOPO_DOM 235 243 Extracellular (Potential). FT TRANSMEM 244 264 5 (Potential). FT TOPO_DOM 265 283 Cytoplasmic (Potential). FT TRANSMEM 284 304 6 (Potential). FT TOPO_DOM 305 315 Extracellular (Potential). FT TRANSMEM 316 336 7 (Potential). FT TOPO_DOM 337 354 Cytoplasmic (Potential). FT CONFLICT 41 41 D -> G (in Ref. 3; AAR08385/BAC33221). FT CONFLICT 116 116 I -> V (in Ref. 1; AAO47230). FT CONFLICT 177 177 I -> L (in Ref. 1; AAO47230). FT CONFLICT 339 339 T -> S (in Ref. 1; AAO47230). SQ SEQUENCE 354 AA; 40430 MW; 14544CBB3338B538 CRC64; MTTAILERLS TLSMSGQQLR RLPKILEEGL PKMPCTVPET DVPQLFREPY IHAGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVEAG ALQWASPHTL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYELFWIFFL PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FVLDISPVAH RVALCHLAGC QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS VCTLSQLEAI LLDYQGRHEI FLQRHGPLSV YSACLSFFVL AACSAATATL LRHKVKDRLI KKDS //