ID MPRB_MOUSE STANDARD; PRT; 354 AA. AC Q80ZE5; Q8C891; Q8CCW9; Q9DA71; DT 25-OCT-2004 (Rel. 45, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ DE receptor family member VIII). GN Name=Mprb; Synonyms=Paqr8; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM 1), AND FUNCTION. RC STRAIN=CD-1; TISSUE=Testis; RX MEDLINE=22506359; PubMed=12601167; DOI=10.1073/pnas.0436133100; RA Zhu Y., Bond J., Thomas P.; RT "Identification, classification, and partial characterization of genes RT in humans and other vertebrates homologous to a fish membrane RT progestin receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003). RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORM 1). RC STRAIN=C57BL/6J; RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J., Emtage P., RA Funk W.; RT "PAQR proteins: a novel membrane receptor family defined by an ancient RT 7-transmembrane pass motif."; RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC STRAIN=C57BL/6J; TISSUE=Head, Medulla oblongata, and Testis; RX MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=C57BL/6; TISSUE=Brain; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP TISSUE SPECIFICITY. RX MEDLINE=21534262; PubMed=11676489; DOI=10.1006/bbrc.2001.5825; RA Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y., RA Inazawa J., Delgado-Escueta A.V., Yamakawa K.; RT "A novel gene in the chromosomal region for juvenile myoclonic RT epilepsy on 6p12 encodes a brain-specific lysosomal membrane RT protein."; RL Biochem. Biophys. Res. Commun. 288:626-636(2001). CC -!- FUNCTION: Steroid membrane receptor. Binds progesterone. May be CC involved in oocyte maturation. CC -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q80ZE5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q80ZE5-2; Sequence=VSP_011194; CC -!- TISSUE SPECIFICITY: Expressed in brain and testis. CC -!- MISCELLANEOUS: May be a G-protein coupled receptor. CC -!- SIMILARITY: Belongs to the ADIPOR family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF313617; AAO47230.1; -; mRNA. DR EMBL; AY424297; AAR08385.1; -; mRNA. DR EMBL; AK006107; BAB24412.1; -; mRNA. DR EMBL; AK029772; BAC26609.1; -; mRNA. DR EMBL; AK031969; BAC27629.1; -; mRNA. DR EMBL; AK048045; BAC33221.1; -; mRNA. DR EMBL; BC059813; AAH59813.1; -; mRNA. DR MGI; MGI:1921479; 1700019B16Rik. DR InterPro; IPR004254; HlyIII_related. DR Pfam; PF03006; HlyIII; 1. KW Alternative splicing; G-protein coupled receptor; Receptor; KW Steroid-binding; Transducer; Transmembrane. FT TOPO_DOM 1 76 Extracellular (Potential). FT TRANSMEM 77 97 1 (Potential). FT TOPO_DOM 98 111 Cytoplasmic (Potential). FT TRANSMEM 112 132 2 (Potential). FT TOPO_DOM 133 173 Extracellular (Potential). FT TRANSMEM 174 194 3 (Potential). FT TOPO_DOM 195 213 Cytoplasmic (Potential). FT TRANSMEM 214 234 4 (Potential). FT TOPO_DOM 235 243 Extracellular (Potential). FT TRANSMEM 244 264 5 (Potential). FT TOPO_DOM 265 283 Cytoplasmic (Potential). FT TRANSMEM 284 304 6 (Potential). FT TOPO_DOM 305 315 Extracellular (Potential). FT TRANSMEM 316 336 7 (Potential). FT TOPO_DOM 337 354 Cytoplasmic (Potential). FT VARSPLIC 324 354 CLSFFVLAACSAATATLLRHKVKDRLIKKDS -> SLLFRF FT SCLQCGHRHPPEAQGQGQTD (in isoform 2). FT /FTId=VSP_011194. FT CONFLICT 41 41 D -> G (in Ref. 3; AAR08385/BAC33221). FT CONFLICT 116 116 I -> V (in Ref. 1). FT CONFLICT 177 177 I -> L (in Ref. 1). FT CONFLICT 339 339 T -> S (in Ref. 1). SQ SEQUENCE 354 AA; 40430 MW; 14544CBB3338B538 CRC64; MTTAILERLS TLSMSGQQLR RLPKILEEGL PKMPCTVPET DVPQLFREPY IHAGYRPTGH EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVEAG ALQWASPHTL PLLLFILSSI TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYELFWIFFL PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FVLDISPVAH RVALCHLAGC QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS VCTLSQLEAI LLDYQGRHEI FLQRHGPLSV YSACLSFFVL AACSAATATL LRHKVKDRLI KKDS //