ID   MYOME_MOUSE             Reviewed;        2224 AA.
AC   Q80YT7; Q05CH5; Q80U00; Q8K240;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   14-MAY-2014, entry version 74.
DE   RecName: Full=Myomegalin;
DE   AltName: Full=Phosphodiesterase 4D-interacting protein;
GN   Name=Pde4dip; Synonyms=Kiaa0454;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT   II. The complete nucleotide sequences of 400 mouse KIAA-homologous
RT   cDNAs identified by screening of terminal sequences of cDNA clones
RT   randomly sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=FVB/N; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as an anchor sequestering components of the
CC       cAMP-dependent pathway to Golgi and/or centrosomes (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with PDE4D (By similarity).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus (By similarity). Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome (By
CC       similarity). Cytoplasm (By similarity). Nucleus (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q80YT7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q80YT7-2; Sequence=VSP_028784, VSP_028785, VSP_028786;
CC   -!- SIMILARITY: Contains 1 NBPF domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH25653.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
CC       Sequence=BAC65568.1; Type=Erroneous initiation;
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DR   EMBL; AK122286; BAC65568.1; ALT_INIT; mRNA.
DR   EMBL; AC130541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC153661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC025653; AAH25653.1; ALT_SEQ; mRNA.
DR   EMBL; BC034266; AAH34266.1; -; mRNA.
DR   EMBL; BC050783; AAH50783.1; -; mRNA.
DR   RefSeq; NP_001034465.2; NM_001039376.2.
DR   RefSeq; NP_835181.2; NM_178080.4. [Q80YT7-2]
DR   UniGene; Mm.129840; -.
DR   ProteinModelPortal; Q80YT7; -.
DR   STRING; 10090.ENSMUSP00000088254; -.
DR   MaxQB; Q80YT7; -.
DR   PaxDb; Q80YT7; -.
DR   PRIDE; Q80YT7; -.
DR   Ensembl; ENSMUST00000045243; ENSMUSP00000040905; ENSMUSG00000038170. [Q80YT7-2]
DR   GeneID; 83679; -.
DR   KEGG; mmu:83679; -.
DR   UCSC; uc008qpg.1; mouse. [Q80YT7-2]
DR   CTD; 9659; -.
DR   MGI; MGI:1891434; Pde4dip.
DR   eggNOG; NOG46262; -.
DR   GeneTree; ENSGT00530000063845; -.
DR   HOGENOM; HOG000113709; -.
DR   HOVERGEN; HBG108166; -.
DR   InParanoid; Q80YT7; -.
DR   KO; K16549; -.
DR   OMA; INDSHSC; -.
DR   PhylomeDB; Q80YT7; -.
DR   TreeFam; TF329233; -.
DR   ChiTaRS; PDE4DIP; mouse.
DR   NextBio; 350723; -.
DR   PRO; PR:Q80YT7; -.
DR   ArrayExpress; Q80YT7; -.
DR   Bgee; Q80YT7; -.
DR   Genevestigator; Q80YT7; -.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030016; C:myofibril; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019899; F:enzyme binding; ISS:UniProtKB.
DR   GO; GO:0043623; P:cellular protein complex assembly; ISS:UniProtKB.
DR   InterPro; IPR010630; NBPF_dom.
DR   InterPro; IPR012943; Spindle_assoc.
DR   Pfam; PF06758; DUF1220; 1.
DR   Pfam; PF07989; Microtub_assoc; 1.
DR   PROSITE; PS51316; NBPF; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW   Cytoskeleton; Golgi apparatus; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN         1   2224       Myomegalin.
FT                                /FTId=PRO_0000307691.
FT   DOMAIN     1497   1588       NBPF.
FT   COILED       41     97       Potential.
FT   COILED      162    205       Potential.
FT   COILED      236    318       Potential.
FT   COILED      350    682       Potential.
FT   COILED      745    822       Potential.
FT   COILED      856    886       Potential.
FT   COILED      949    986       Potential.
FT   COILED     1159   1187       Potential.
FT   COILED     1295   1331       Potential.
FT   COILED     1377   1401       Potential.
FT   COILED     1769   1958       Potential.
FT   COILED     2148   2191       Potential.
FT   MOD_RES     705    705       Phosphothreonine (By similarity).
FT   VAR_SEQ       1    211       MSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEVSR
FT                                EDVYKRNIELKVEVESLKRELQDRKQHLDKTWADAEDLNSQ
FT                                NEAELRRQVEERQQETEHVYELLGNKIQLLQEEPRLAKNEA
FT                                TEMETLVEAEKRCNLELSERWTNAAKNREDAAGDQEKPDQY
FT                                SEALAQRDRRIEELRQSLAAQEGLVEQLSQEKRQLLHLLEE
FT                                PASMEV -> MKEICRICARELCGNQRRWIFHTASKLNLQV
FT                                LLSHVLGKDVSRDGKAEFACSKCAFMLDRIYRFDTVIARIE
FT                                ALSLERLQKLLLEKDRLKFCIASMYRKNNDDSGEENKAGSG
FT                                TVDISGLPDMRYAALLQEDFAYSGFECWVENEDQINDSHSC
FT                                HASEGPGNRPRRCRGCAALRVADSDYEAICKVPRKVARSIS
FT                                YAPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEG
FT                                TPGSSVESLDASVQASPPQQKDEETERSAKELVKCDYCSDE
FT                                QAPQHLCNHKLELALSMIKGLDYKPIQSPRGSKLPIPVKSI
FT                                LPGAKPGHILTNGVSSSFLNRPLKPLYRTPVSYPWEISDGQ
FT                                ELWDDLCDEYLPIGF (in isoform 2).
FT                                /FTId=VSP_028784.
FT   VAR_SEQ     950    955       QEMLHL -> RHKHAF (in isoform 2).
FT                                /FTId=VSP_028785.
FT   VAR_SEQ     956   2224       Missing (in isoform 2).
FT                                /FTId=VSP_028786.
SQ   SEQUENCE   2224 AA;  250631 MW;  D3EA6F593ACD2445 CRC64;
     MSNGYRTLSQ HLNDLKKENF SLKLRIYFLE ERMQQKYEVS REDVYKRNIE LKVEVESLKR
     ELQDRKQHLD KTWADAEDLN SQNEAELRRQ VEERQQETEH VYELLGNKIQ LLQEEPRLAK
     NEATEMETLV EAEKRCNLEL SERWTNAAKN REDAAGDQEK PDQYSEALAQ RDRRIEELRQ
     SLAAQEGLVE QLSQEKRQLL HLLEEPASME VQPVPKGLPT QQKPDLHETP TTQPPVSESH
     LAELQDKIQQ TEATNKILQE KLNDLSCELK SAQESSQKQD TTIQSLKEML KSRESETEEL
     YQVIEGQNDT MAKLREMLHQ SQLGQLHSSE GIAPAQQQVA LLDLQSALFC SQLEIQRLQR
     LVRQKERQLA DGKRCVQLVE AAAQEREHQK EAAWKHNQEL RKALQHLQGE LHSKSQQLHV
     LEAEKYNEIR TQGQNIQHLS HSLSHKEQLI QELQELLQYR DNADKTLDTN EVFLEKLRQR
     IQDRAVALER VIDEKFSALE EKDKELRQLR LAVRDRDHDL ERLRCVLSAN EATMQSMESL
     LRARGLEVEQ LTATCQNLQW LKEELETKFG HWQKEQESII QQLQTSLHDR NKEVEDLSAT
     LLCKLGPGQS EVAEELCQRL QRKERMLQDL LSDRNKQAVE HEMEIQGLLQ SMGTREQERQ
     AAAEKMVQAF MERNSELQAL RQYLGGKELM TSSQTFISNQ PAGVTSIGPH HGEQTDQGSM
     QMPSRDDSTS LTAREEASIP RSTLGDSDTV AGLEKELSNA KEELELMAKK ERESQMELSA
     LQSMMAMQEE ELQVQAADLE SLTRNVQIKE DLIKDLQMQL VDPEDIPAME RLTQEVLLLR
     EKVASVEPQG QEVSGNKRQQ LLLMLEGLVD ERSRLNEALQ AERQLYSSLV KFHAQPENSE
     RDGTLQVELE GAQVLRTRLE EVLGRSLERL SRLESLAAIG GGELESVQAQ EMLHLRAEIH
     QHLEEKRKAE VELKELKAQI EEAGFSSVSH ISRNTMLSLC LENAELKEQM GEAMSDGWEV
     EEDKEKGEVM LETVVAKGCL NENSLQAEFR KVQGKLKSAY NIINLLKEQL LLRSSEGNSK
     EMPELLVRLA REVDRMNTGL PSLGKHQHQE QENTTTARPG SRPQSLPLGA ALSVDGYQLE
     NKSQAQDSGH QPEFSLPGST KHLRSQLAQC RQRYQDLQEK LLISEATVFA QANQLEKYRA
     VFSESLVKQD SKQIQVDLQD LGYETCGRSE NEAEREETTS PECEEHNNLR PVVLMEGLCS
     EQGYLDPVLV SPPAKKPLEN KPGKQEEFRA HGTPDDSSLL RKDIRDLKAQ LQNANKVIQN
     LRSRVRSLSA TSDYSSSLER PRKLRAVATL EGASPHSVTD EDEGWLSDGT GAFYPPGLQA
     KKDLESLIQR VSQLEAQLPK TGLEGKLAEE LRCASWPGKY DSLIQDQARE LSYLRQKIRE
     GRGICYLLTQ HAKDTVKSFE DLLRSNDIDY YLGQSFREQL AQGGQLTERL TSKLSTKDHK
     SEKEEAGLEP LALRLSRELQ EKEKVIEVLQ AKLDTRSLSP PSSHAVSDSH RSASTTSFLS
     DDIEACSDMD VASEYTHYDE KKPSPSHSAA SASQGLKGES SSSPISLPTP QNPPKEASQA
     HPGFHFHSIP KPASLSQTPM HSALPSFVPF SPSGPPLLGC CETPMVSLAE AQQELQMLQK
     QLGESVSIAP PASTSTLLSN QTEASSPHYI NPAQPHTPTR STIELGRILE PGYLGSSGQW
     DMMRPQKGSV SGELSSGSSM YQLNSKPTGA DLLEEHLGEI RNLRQRLEES ICVNDRLREQ
     LQHRLSSTAR ENGSTSHFYS QGLESMPQLY NENRALREEN QSLQTRLSHA SRGHSQEVDH
     LREALLSSRS QLQELEKELE QQKAERQQLS LQSELQIYES LCENPKKALK AFSLDSCHQV
     PGELSCLVAE IRALRGQLEQ SIEVNNRLRL QLEQQMDRGA GKASLGPIAV GQSFPDKAEP
     ANLHQGSAAS PPVRDVGLNS PAMVLPNSSC SAPGSDHAIV TRTNNELSSD DSAAMKNPPK
     LEVDATDGPF ANKHGRHVIG HVDDYDALQQ QIGEGKLLIQ KILSLMRSAR SIPGQEAQDT
     EAPGNISAHE LRSSAKALNH ALEESTSLLN MFWRAALPNT HGPVLVGKEG QLMEKELLDL
     RAQVSQQEQI LQNTAARLKR ANQRKKSMEQ FIVSHLTRTH DVLKKARTNL EMKSFRALTC
     TPAL
//