ID Q80XG0_PERMA Unreviewed; 61 AA. AC Q80XG0; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 28-JUN-2023, entry version 61. DE RecName: Full=Interleukin-12 subunit alpha {ECO:0000256|ARBA:ARBA00014463, ECO:0000256|RuleBase:RU363133}; DE Short=IL-12A {ECO:0000256|RuleBase:RU363133}; DE Flags: Fragment; GN Name=Il12a {ECO:0000313|EMBL:AAP04422.1}; GN Synonyms=IL12A {ECO:0000256|RuleBase:RU363133}; OS Peromyscus maniculatus (North American deer mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; OC Cricetidae; Neotominae; Peromyscus. OX NCBI_TaxID=10042 {ECO:0000313|EMBL:AAP04422.1}; RN [1] {ECO:0000313|EMBL:AAP04422.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=14720307; DOI=10.1186/1471-2172-5-1; RA Schountz T., Green R., Davenport B., Buniger A., Richens T., Root J.J., RA Davidson F., Calisher C.H., Beaty B.J.; RT "Cloning and characterization of deer mouse (Peromyscus maniculatus) RT cytokine and chemokine cDNAs."; RL BMC Immunol. 5:1-1(2004). CC -!- FUNCTION: Heterodimerizes with IL12B to form the IL-12 cytokine or with CC EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by CC professional antigen-presenting cells (APCs) such as B-cells and CC dendritic cells (DCs) as well as macrophages and granulocytes and CC regulates T-cell and natural killer-cell responses, induces the CC production of interferon-gamma (IFN-gamma), favors the differentiation CC of T-helper 1 (Th1) cells and is an important link between innate CC resistance and adaptive immunity. Mechanistically, exerts its CC biological effects through a receptor composed of IL12R1 and IL12R2 CC subunits. Binding to the receptor results in the rapid tyrosine CC phosphorylation of a number of cellular substrates including the JAK CC family kinases TYK2 and JAK2. In turn, recruited STAT4 gets CC phosphorylated and translocates to the nucleus where it regulates CC cytokine/growth factor responsive genes. As part of IL-35, plays CC essential roles in maintaining the immune homeostasis of the liver CC microenvironment and functions also as an immune-suppressive cytokine. CC Mediates biological events through unconventional receptors composed of CC IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires CC the transcription factors STAT1 and STAT4, which form a unique CC heterodimer that binds to distinct DNA sites. CC {ECO:0000256|RuleBase:RU363133}. CC -!- SUBUNIT: Heterodimer with IL12B; disulfide-linked. The heterodimer is CC known as interleukin IL-12. {ECO:0000256|RuleBase:RU363133}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU363133}. CC -!- SIMILARITY: Belongs to the IL-6 superfamily. CC {ECO:0000256|RuleBase:RU363133}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY247763; AAP04422.1; -; mRNA. DR AlphaFoldDB; Q80XG0; -. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005143; F:interleukin-12 receptor binding; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR004281; IL-12_alpha. DR Pfam; PF03039; IL12; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. PE 2: Evidence at transcript level; KW Cytokine {ECO:0000256|RuleBase:RU363133}; KW Disulfide bond {ECO:0000256|RuleBase:RU363133}; KW Growth factor {ECO:0000256|RuleBase:RU363133}; KW Secreted {ECO:0000256|RuleBase:RU363133}. FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAP04422.1" FT NON_TER 61 FT /evidence="ECO:0000313|EMBL:AAP04422.1" SQ SEQUENCE 61 AA; 6975 MW; 43FF88BD8ED8746F CRC64; HLSLARATPV SRPAQCLDHS KNLLRTTKHM LEKARQTLRH YPCTPEDVDY EDITGEKTST L //