ID NPM2_MOUSE STANDARD; PRT; 207 AA. AC Q80W85; Q8BW23; DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 27-JUN-2006, entry version 22. DE Nucleoplasmin-2. GN Name=Npm2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RC STRAIN=129S6/SvEv; RX MEDLINE=22600957; PubMed=12714744; DOI=10.1126/science.1081813; RA Burns K.H., Viveiros M.M., Ren Y., Wang P., DeMayo F.J., Frail D.E., RA Eppig J.J., Matzuk M.M.; RT "Roles of NPM2 in chromatin and nucleolar organization in oocytes and RT embryos."; RL Science 300:633-636(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Ovary; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC -!- FUNCTION: Probably involved in sperm DNA decondensation during CC fertilization. CC -!- SUBCELLULAR LOCATION: Nucleus. Found in the oocyte nucleus before CC nuclear membrane breakdown, after which it is redistributed to the CC cytoplasm. CC -!- TISSUE SPECIFICITY: Ovary specific. CC -!- SIMILARITY: Belongs to the nucleoplasmin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY262112; AAP33133.1; -; mRNA. DR EMBL; AK054533; BAC35815.1; -; mRNA. DR HSSP; P05221; 1K5J. DR Ensembl; ENSMUSG00000047911; Mus musculus. DR MGI; MGI:1890811; Npm2. DR GO; GO:0000789; C:cytoplasmic chromatin; ISS. DR GO; GO:0000790; C:nuclear chromatin; ISS. DR GO; GO:0005634; C:nucleus; ISS. DR GO; GO:0042393; F:histone binding; ISS. DR GO; GO:0006338; P:chromatin remodeling; ISS. DR GO; GO:0009790; P:embryonic development; ISS. DR GO; GO:0007338; P:fertilization (sensu Metazoa); ISS. DR GO; GO:0009994; P:oocyte differentiation; ISS. DR GO; GO:0045836; P:positive regulation of meiosis; ISS. DR GO; GO:0007096; P:regulation of exit from mitosis; ISS. DR GO; GO:0006445; P:regulation of translation; ISS. DR InterPro; IPR004301; Nucleoplasmin. DR Pfam; PF03066; Nucleoplasmin; 1. KW Nuclear protein. FT CHAIN 1 207 Nucleoplasmin-2. FT /FTId=PRO_0000219488. FT COMPBIAS 128 141 Poly-Glu. FT COMPBIAS 168 171 Poly-Lys. FT CONFLICT 196 196 S -> F (in Ref. 2). SQ SEQUENCE 207 AA; 23309 MW; 8B8A8931F85032EE CRC64; MSRHSTSSVT ETTAKNMLWG SELNQEKQTC TFRGQGEKKD SCKLLLSTIC LGEKAKEEVN RVEVLSQEGR KPPITIATLK ASVLPMVTVS GIELSPPVTF RLRTGSGPVF LSGLECYETS DLTWEDDEEE EEEEEEEDED EDADISLEEI PVKQVKRVAP QKQMSIAKKK KVEKEEDETV VRPSPQDKSP WKKEKSTPRA KKPVTKK //