ID NPM2_MOUSE STANDARD; PRT; 207 AA. AC Q80W85; Q8BW23; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE Nucleoplasmin 2. GN Name=Npm2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RC STRAIN=129S6/SvEv; RX MEDLINE=22600957; PubMed=12714744; DOI=10.1126/science.1081813; RA Burns K.H., Viveiros M.M., Ren Y., Wang P., DeMayo F.J., Frail D.E., RA Eppig J.J., Matzuk M.M.; RT "Roles of NPM2 in chromatin and nucleolar organization in oocytes and RT embryos."; RL Science 300:633-636(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Ovary; RX MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). CC -!- FUNCTION: Probably involved in sperm DNA decondensation during CC fertilization. CC -!- SUBCELLULAR LOCATION: Nuclear. Found in the oocyte nucleus before CC nuclear membrane breakdown, after which it is redistributed to the CC cytoplasm. CC -!- TISSUE SPECIFICITY: Ovary specific. CC -!- SIMILARITY: Belongs to the nucleoplasmin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY262112; AAP33133.1; -; mRNA. DR EMBL; AK054533; BAC35815.1; -; mRNA. DR HSSP; P05221; 1K5J. DR Ensembl; ENSMUSG00000047911; Mus musculus. DR MGI; MGI:1890811; Npm2. DR GO; GO:0000789; C:cytoplasmic chromatin; ISS. DR GO; GO:0000790; C:nuclear chromatin; ISS. DR GO; GO:0005634; C:nucleus; ISS. DR GO; GO:0042393; F:histone binding; ISS. DR GO; GO:0006338; P:chromatin remodeling; ISS. DR GO; GO:0009790; P:embryonic development; ISS. DR GO; GO:0007338; P:fertilization (sensu Metazoa); ISS. DR GO; GO:0009994; P:oocyte differentiation; ISS. DR GO; GO:0045836; P:positive regulation of meiosis; ISS. DR GO; GO:0007096; P:regulation of exit from mitosis; ISS. DR GO; GO:0006445; P:regulation of translation; ISS. DR InterPro; IPR004301; Nucleoplasmin. DR Pfam; PF03066; Nucleoplasmin; 1. KW Nuclear protein. FT COMPBIAS 128 141 Poly-Glu. FT COMPBIAS 168 171 Poly-Lys. FT CONFLICT 196 196 S -> F (in Ref. 2). SQ SEQUENCE 207 AA; 23309 MW; 8B8A8931F85032EE CRC64; MSRHSTSSVT ETTAKNMLWG SELNQEKQTC TFRGQGEKKD SCKLLLSTIC LGEKAKEEVN RVEVLSQEGR KPPITIATLK ASVLPMVTVS GIELSPPVTF RLRTGSGPVF LSGLECYETS DLTWEDDEEE EEEEEEEDED EDADISLEEI PVKQVKRVAP QKQMSIAKKK KVEKEEDETV VRPSPQDKSP WKKEKSTPRA KKPVTKK //