ID Q80SV8_MOUSE Unreviewed; 1013 AA. AC Q80SV8; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 23-MAR-2010, entry version 57. DE SubName: Full=NOD2; GN Name=Nod2; Synonyms=Card15; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SM/J, AU/SsJ, and NZW/LacJ; RX MEDLINE=22563394; PubMed=12676561; DOI=10.1016/S0888-7543(03)00027-2; RA Ogura Y., Saab L., Chen F.F., Benito A., Inohara N., Nunez G.; RT "Genetic variation and activity of mouse Nod2, a susceptibility gene RT for Crohn's disease."; RL Genomics 81:369-377(2003). CC -!- SIMILARITY: Contains 1 NACHT domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY160388; AAN57791.1; -; Genomic_DNA. DR EMBL; AY160380; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160381; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160382; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160383; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160384; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160385; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160386; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160387; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160468; AAN59994.1; -; Genomic_DNA. DR EMBL; AY160460; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160461; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160462; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160463; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160464; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160465; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160466; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160467; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160638; AAN63037.1; -; Genomic_DNA. DR EMBL; AY160630; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160631; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160632; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160633; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160634; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160635; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160636; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160637; AAN63037.1; JOINED; Genomic_DNA. DR IPI; IPI00230403; -. DR UniGene; Mm.222633; -. DR SMR; Q80SV8; 5-85, 104-180, 739-1000. DR STRING; Q80SV8; -. DR Ensembl; ENSMUST00000109634; ENSMUSP00000105262; ENSMUSG00000055994; Mus musculus. DR Ensembl; ENSMUST00000118370; ENSMUSP00000113773; ENSMUSG00000055994; Mus musculus. DR MGI; MGI:2429397; Nod2. DR HOVERGEN; HBG050792; -. DR ArrayExpress; Q80SV8; -. DR Bgee; Q80SV8; -. DR Genevestigator; Q80SV8; -. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0016888; F:endodeoxyribonuclease activity, producing 5...; IEA:InterPro. DR GO; GO:0005515; F:protein binding; IPI:MGI. DR GO; GO:0002253; P:activation of immune response; IMP:MGI. DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI. DR GO; GO:0002381; P:immunoglobulin production during immune res...; IMP:MGI. DR GO; GO:0002227; P:innate immune response in mucosa; IMP:MGI. DR GO; GO:0071608; P:macrophage inflammatory protein-1 alpha pro...; IMP:MGI. DR GO; GO:0044130; P:negative regulation of growth of symbiont i...; IMP:MGI. DR GO; GO:0032689; P:negative regulation of interferon-gamma pro...; IMP:MGI. DR GO; GO:0032695; P:negative regulation of interleukin-12 produ...; IDA:MGI. DR GO; GO:0032701; P:negative regulation of interleukin-18 produ...; IMP:MGI. DR GO; GO:0032703; P:negative regulation of interleukin-2 produc...; IMP:MGI. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcript...; IMP:MGI. DR GO; GO:0034136; P:negative regulation of toll-like receptor 2...; IMP:MGI. DR GO; GO:0032720; P:negative regulation of tumor necrosis facto...; IMP:MGI. DR GO; GO:0006965; P:positive regulation of biosynthetic process...; IMP:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI. DR GO; GO:0002925; P:positive regulation of humoral immune respo...; IMP:MGI. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IDA:MGI. DR GO; GO:0045089; P:positive regulation of innate immune response; IMP:MGI. DR GO; GO:0032735; P:positive regulation of interleukin-12 produ...; IDA:MGI. DR GO; GO:0032755; P:positive regulation of interleukin-6 produc...; IDA:MGI. DR GO; GO:0046330; P:positive regulation of JNK cascade; IDA:MGI. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcript...; IMP:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine ph...; IMP:MGI. DR GO; GO:0050766; P:positive regulation of phagocytosis; IMP:MGI. DR GO; GO:0032874; P:positive regulation of stress-activated MAP...; IDA:MGI. DR GO; GO:0032760; P:positive regulation of tumor necrosis facto...; IDA:MGI. DR GO; GO:0042981; P:regulation of apoptosis; IEA:InterPro. DR GO; GO:0090022; P:regulation of neutrophil chemotaxis; IMP:MGI. DR GO; GO:0043330; P:response to exogenous dsRNA; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI. DR GO; GO:0032495; P:response to muramyl dipeptide; IDA:MGI. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH-like. DR InterPro; IPR018228; DNase_TatD-rel_CS. DR InterPro; IPR007111; NACHT_NTPase. DR Gene3D; G3DSA:1.10.533.10; DEATH_like; 1. DR Pfam; PF00619; CARD; 2. DR SUPFAM; SSF47986; DEATH_like; 2. DR PROSITE; PS50209; CARD; 2. DR PROSITE; PS50837; NACHT; 1. DR PROSITE; PS01137; TATD_1; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 1013 AA; 112804 MW; 9D41BA39FAC1905E CRC64; MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELHGSWDTHS VHPTRDLQSH RPAIVRRLYN HVEAMLELAR EGGFLSQYEC EEIRLPIFTS SQRARRLLDL AAVKANGLAA FLLQHVRELP ALLPLPYEAA ECQKFISKLR TMVLAQSRFL STYDGSENLC LEDIYTENIL ELRTEVGTAG ALQKSPAILG LEDLFDTHGH LNRDADTILV VGEAGSGKST LLQRLHLLWA TGRSFQEFLF IFPFSCRQLQ CVAKPLSLRT LLFEHCCWPD VAQDDVFQFL LDHPDRVLLT FDGLDEFKFR FTDRERHCSP IDPTSVQTLL FNLLQGNLLK NACKVLTSRP DAVSALLRKF VRTECQLKGF SEEGIQLYLR KHHREPGVAD RLIQLIQATS ALHGLCHLPV FSWMVSRCHR ELLLQNRVFP TTSTDMYLLI LQHFLLHASP PDSSPFGLGP GLLQSRLSTL LHLGHLALRG LAMSCYVFSA QQLQAAQVDS DDISLGFLVR AQSSVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK HLFSCGRLGS SLLGRLLPNL CIQGSRVKKG SEAALLQKAE PHNLQITAAF LAGLLSQQHR DLLAACQISE RVLLQRQARA RSCLAHSLRE HFHSIPPAVP GETKSMHAMP GFIWLIRSLY EMQEEQLAQE AVRRLDIGHL KLTFCRVGPA ECAALAFVLQ HLQRPVALQL DYNSVGDVGV EQLRPCLGVC TALYLRDNNI SDRGARTLVE CALRCEQLQK LALFNNKLTD ACACSMAKLL AHKQNFLSLR VGNNHITAAG AEVLAQGLKS NTSLKFLGFW GNSVGDKGTQ ALAEVVADHQ NLKWLSLVGN NIGSMGAQAL ALMLEKNKSL EELCLEENHI CDEGVYSLAE GLKRNSTLKF LKLSNNGITY RGAEALLQAL SRNSAILEVW LRGNTFSLEE IQTLSSRDAR LLL //