ID Q80SV8_MOUSE Unreviewed; 1013 AA. AC Q80SV8; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 10-FEB-2009, entry version 45. DE SubName: Full=NOD2; GN Name=Nod2; Synonyms=Card15; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=SM/J, AU/SsJ, and NZW/LacJ; RX MEDLINE=22563394; PubMed=12676561; DOI=10.1016/S0888-7543(03)00027-2; RA Ogura Y., Saab L., Chen F.F., Benito A., Inohara N., Nunez G.; RT "Genetic variation and activity of mouse Nod2, a susceptibility gene RT for Crohn's disease."; RL Genomics 81:369-377(2003). CC -!- SIMILARITY: Contains 1 NACHT domain. CC -!- SIMILARITY: Contains 2 CARD domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY160388; AAN57791.1; -; Genomic_DNA. DR EMBL; AY160380; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160381; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160382; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160383; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160384; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160385; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160386; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160387; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160468; AAN59994.1; -; Genomic_DNA. DR EMBL; AY160460; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160461; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160462; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160463; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160464; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160465; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160466; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160467; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160638; AAN63037.1; -; Genomic_DNA. DR EMBL; AY160630; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160631; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160632; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160633; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160634; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160635; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160636; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160637; AAN63037.1; JOINED; Genomic_DNA. DR UniGene; Mm.222633; -. DR IPI; IPI00230403; -. DR Ensembl; ENSMUSG00000055994; Mus musculus. DR MGI; MGI:2429397; Nod2. DR HOVERGEN; Q80SV8; -. DR ArrayExpress; Q80SV8; -. DR Bgee; Q80SV8; -. DR GO; GO:0009986; C:cell surface; IEA:Compara. DR GO; GO:0005829; C:cytosol; IEA:Compara. DR GO; GO:0005886; C:plasma membrane; IEA:Compara. DR GO; GO:0008180; C:signalosome; IEA:Compara. DR GO; GO:0031982; C:vesicle; IEA:Compara. DR GO; GO:0050700; F:CARD domain binding; IEA:Compara. DR GO; GO:0016888; F:endodeoxyribonuclease activity, producing 5...; IEA:InterPro. DR GO; GO:0032500; F:muramyl dipeptide binding; IEA:Compara. DR GO; GO:0019901; F:protein kinase binding; IEA:Compara. DR GO; GO:0002367; P:cytokine production during immune response; IEA:Compara. DR GO; GO:0016045; P:detection of bacterium; IEA:Compara. DR GO; GO:0032498; P:detection of muramyl dipeptide; IEA:Compara. DR GO; GO:0002381; P:immunoglobulin production during immune res...; IMP:MGI. DR GO; GO:0002227; P:innate immune response in mucosa; IMP:MGI. DR GO; GO:0032689; P:negative regulation of interferon-gamma pro...; IMP:MGI. DR GO; GO:0032695; P:negative regulation of interleukin-12 produ...; IDA:MGI. DR GO; GO:0032701; P:negative regulation of interleukin-18 produ...; IMP:MGI. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcript...; IMP:MGI. DR GO; GO:0034136; P:negative regulation of toll-like receptor 2...; IMP:MGI. DR GO; GO:0006965; P:positive regulation of biosynthetic process...; IMP:MGI. DR GO; GO:0002925; P:positive regulation of humoral immune respo...; IMP:MGI. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IEA:Compara. DR GO; GO:0050718; P:positive regulation of interleukin-1 beta s...; IEA:Compara. DR GO; GO:0032735; P:positive regulation of interleukin-12 produ...; IDA:MGI. DR GO; GO:0032735; P:positive regulation of interleukin-12 produ...; IMP:MGI. DR GO; GO:0032740; P:positive regulation of interleukin-17 produ...; IEA:Compara. DR GO; GO:0032755; P:positive regulation of interleukin-6 produc...; IMP:MGI. DR GO; GO:0043410; P:positive regulation of MAPKKK cascade; IMP:MGI. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcript...; IMP:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine ph...; IMP:MGI. DR GO; GO:0032760; P:positive regulation of tumor necrosis facto...; IMP:MGI. DR GO; GO:0042981; P:regulation of apoptosis; IEA:InterPro. DR GO; GO:0043330; P:response to exogenous dsRNA; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH_like. DR InterPro; IPR001130; DNase_TatD-rel. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR007111; NACHT_NTPase. DR Gene3D; G3DSA:1.10.533.10; DEATH_like; 1. DR Pfam; PF00619; CARD; 2. DR Pfam; PF00560; LRR_1; 1. DR Pfam; PF05729; NACHT; 1. DR PROSITE; PS50209; CARD; 2. DR PROSITE; PS50837; NACHT; 1. DR PROSITE; PS01137; TATD_1; 1. PE 2: Evidence at transcript level; SQ SEQUENCE 1013 AA; 112804 MW; 9D41BA39FAC1905E CRC64; MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELHGSWDTHS VHPTRDLQSH RPAIVRRLYN HVEAMLELAR EGGFLSQYEC EEIRLPIFTS SQRARRLLDL AAVKANGLAA FLLQHVRELP ALLPLPYEAA ECQKFISKLR TMVLAQSRFL STYDGSENLC LEDIYTENIL ELRTEVGTAG ALQKSPAILG LEDLFDTHGH LNRDADTILV VGEAGSGKST LLQRLHLLWA TGRSFQEFLF IFPFSCRQLQ CVAKPLSLRT LLFEHCCWPD VAQDDVFQFL LDHPDRVLLT FDGLDEFKFR FTDRERHCSP IDPTSVQTLL FNLLQGNLLK NACKVLTSRP DAVSALLRKF VRTECQLKGF SEEGIQLYLR KHHREPGVAD RLIQLIQATS ALHGLCHLPV FSWMVSRCHR ELLLQNRVFP TTSTDMYLLI LQHFLLHASP PDSSPFGLGP GLLQSRLSTL LHLGHLALRG LAMSCYVFSA QQLQAAQVDS DDISLGFLVR AQSSVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK HLFSCGRLGS SLLGRLLPNL CIQGSRVKKG SEAALLQKAE PHNLQITAAF LAGLLSQQHR DLLAACQISE RVLLQRQARA RSCLAHSLRE HFHSIPPAVP GETKSMHAMP GFIWLIRSLY EMQEEQLAQE AVRRLDIGHL KLTFCRVGPA ECAALAFVLQ HLQRPVALQL DYNSVGDVGV EQLRPCLGVC TALYLRDNNI SDRGARTLVE CALRCEQLQK LALFNNKLTD ACACSMAKLL AHKQNFLSLR VGNNHITAAG AEVLAQGLKS NTSLKFLGFW GNSVGDKGTQ ALAEVVADHQ NLKWLSLVGN NIGSMGAQAL ALMLEKNKSL EELCLEENHI CDEGVYSLAE GLKRNSTLKF LKLSNNGITY RGAEALLQAL SRNSAILEVW LRGNTFSLEE IQTLSSRDAR LLL //