ID Q80SV8_MOUSE Unreviewed; 1013 AA. AC Q80SV8; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 27-MAR-2024, entry version 121. DE SubName: Full=NOD2 {ECO:0000313|EMBL:AAN57791.1}; GN Name=Nod2 {ECO:0000313|EMBL:AAN57791.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAN57791.1}; RN [1] {ECO:0000313|EMBL:AAN57791.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AU/SsJ {ECO:0000313|EMBL:AAN63037.1}, NZW/LacJ RC {ECO:0000313|EMBL:AAN59994.1}, and SM/J {ECO:0000313|EMBL:AAN57791.1}; RX PubMed=12676561; DOI=10.1016/S0888-7543(03)00027-2; RA Ogura Y., Saab L., Chen F.F., Benito A., Inohara N., Nunez G.; RT "Genetic variation and activity of mouse Nod2, a susceptibility gene for RT Crohn's disease."; RL Genomics 81:369-377(2003). CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane CC {ECO:0000256|ARBA:ARBA00004124}. Membrane CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor CC {ECO:0000256|ARBA:ARBA00004635}. CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family. CC {ECO:0000256|ARBA:ARBA00038296}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AH012073; AAN57791.1; -; Genomic_DNA. DR EMBL; AY160380; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160381; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160382; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160383; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160384; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160386; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AY160387; AAN57791.1; JOINED; Genomic_DNA. DR EMBL; AH012079; AAN59994.1; -; Genomic_DNA. DR EMBL; AY160460; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160461; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160462; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160463; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160465; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160466; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AY160467; AAN59994.1; JOINED; Genomic_DNA. DR EMBL; AH012154; AAN63037.1; -; Genomic_DNA. DR EMBL; AY160630; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160631; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160632; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160634; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160635; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160636; AAN63037.1; JOINED; Genomic_DNA. DR EMBL; AY160637; AAN63037.1; JOINED; Genomic_DNA. DR AlphaFoldDB; Q80SV8; -. DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:UniProt. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR GO; GO:0045088; P:regulation of innate immune response; IEA:UniProt. DR Gene3D; 1.10.533.10; Death Domain, Fas; 2. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1. DR InterPro; IPR001315; CARD. DR InterPro; IPR011029; DEATH-like_dom_sf. DR InterPro; IPR018228; DNase_TatD-rel_CS. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR007111; NACHT_NTPase. DR InterPro; IPR041267; NLRP_HD2. DR InterPro; IPR041075; NOD2_WH. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1. DR PANTHER; PTHR24106:SF278; RNI-LIKE SUPERFAMILY PROTEIN; 1. DR Pfam; PF00619; CARD; 1. DR Pfam; PF13516; LRR_6; 5. DR Pfam; PF05729; NACHT; 1. DR Pfam; PF17776; NLRC4_HD2; 1. DR Pfam; PF17779; NOD2_WH; 1. DR SMART; SM00368; LRR_RI; 8. DR SUPFAM; SSF47986; DEATH domain; 2. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF52047; RNI-like; 1. DR PROSITE; PS50209; CARD; 2. DR PROSITE; PS50837; NACHT; 1. DR PROSITE; PS01137; TATD_1; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Innate immunity {ECO:0000256|ARBA:ARBA00022588}; KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT DOMAIN 1..82 FT /note="CARD" FT /evidence="ECO:0000259|PROSITE:PS50209" FT DOMAIN 107..178 FT /note="CARD" FT /evidence="ECO:0000259|PROSITE:PS50209" FT DOMAIN 266..402 FT /note="NACHT" FT /evidence="ECO:0000259|PROSITE:PS50837" SQ SEQUENCE 1013 AA; 112804 MW; 9D41BA39FAC1905E CRC64; MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELHGSWDTHS VHPTRDLQSH RPAIVRRLYN HVEAMLELAR EGGFLSQYEC EEIRLPIFTS SQRARRLLDL AAVKANGLAA FLLQHVRELP ALLPLPYEAA ECQKFISKLR TMVLAQSRFL STYDGSENLC LEDIYTENIL ELRTEVGTAG ALQKSPAILG LEDLFDTHGH LNRDADTILV VGEAGSGKST LLQRLHLLWA TGRSFQEFLF IFPFSCRQLQ CVAKPLSLRT LLFEHCCWPD VAQDDVFQFL LDHPDRVLLT FDGLDEFKFR FTDRERHCSP IDPTSVQTLL FNLLQGNLLK NACKVLTSRP DAVSALLRKF VRTECQLKGF SEEGIQLYLR KHHREPGVAD RLIQLIQATS ALHGLCHLPV FSWMVSRCHR ELLLQNRVFP TTSTDMYLLI LQHFLLHASP PDSSPFGLGP GLLQSRLSTL LHLGHLALRG LAMSCYVFSA QQLQAAQVDS DDISLGFLVR AQSSVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSAASLK HLFSCGRLGS SLLGRLLPNL CIQGSRVKKG SEAALLQKAE PHNLQITAAF LAGLLSQQHR DLLAACQISE RVLLQRQARA RSCLAHSLRE HFHSIPPAVP GETKSMHAMP GFIWLIRSLY EMQEEQLAQE AVRRLDIGHL KLTFCRVGPA ECAALAFVLQ HLQRPVALQL DYNSVGDVGV EQLRPCLGVC TALYLRDNNI SDRGARTLVE CALRCEQLQK LALFNNKLTD ACACSMAKLL AHKQNFLSLR VGNNHITAAG AEVLAQGLKS NTSLKFLGFW GNSVGDKGTQ ALAEVVADHQ NLKWLSLVGN NIGSMGAQAL ALMLEKNKSL EELCLEENHI CDEGVYSLAE GLKRNSTLKF LKLSNNGITY RGAEALLQAL SRNSAILEVW LRGNTFSLEE IQTLSSRDAR LLL //