ID Q7ZZ37_DANRE Unreviewed; 128 AA. AC Q7ZZ37; F6NHA1; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 03-MAY-2023, entry version 126. DE SubName: Full=Ppp1r14b protein {ECO:0000313|EMBL:AAI65900.1}; DE SubName: Full=Protein phosphatase 1, regulatory (Inhibitor) subunit 14B {ECO:0000313|EMBL:AAH76513.1}; DE SubName: Full=protein phosphatase 1, regulatory (inhibitor) subunit 14Bb {ECO:0000313|Ensembl:ENSDARP00000039826, ECO:0000313|RefSeq:NP_001002692.1}; GN Name=ppp1r14b {ECO:0000313|EMBL:AAI65900.1, GN ECO:0000313|RefSeq:NP_001002692.1}; GN Synonyms=plcb3n {ECO:0000313|RefSeq:NP_001002692.1}, si:zc188c22.2 GN {ECO:0000313|RefSeq:NP_001002692.1}, si:zc194c5.1 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fa01d09 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fb59a08 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fc32d08 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fk27d06 GN {ECO:0000313|RefSeq:NP_001002692.1}, zgc:91822 GN {ECO:0000313|RefSeq:NP_001002692.1}; GN OrderedLocusNames=ppp1r14bb {ECO:0000313|Ensembl:ENSDARP00000039826, GN ECO:0000313|RefSeq:NP_001002692.1, GN ECO:0000313|ZFIN:ZDB-GENE-030616-595}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65900.1}; RN [1] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11116086; RA Woods I.G., Kelly P.D., Chu F., Ngo-Hazelett P., Yan Y.L., Huang H., RA Postlethwait J.H., Talbot W.S.; RT "A comparative map of the zebrafish genome."; RL Genome Res. 10:1903-1914(2000). RN [2] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16109975; RA Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R., RA Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.; RT "The zebrafish gene map defines ancestral vertebrate chromosomes."; RL Genome Res. 15:1307-1314(2005). RN [3] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18339436; RA Hoffmann J.L., Thomason R.G., Lee D.M., Brill J.L., Price B.B., Carr G.J., RA Versteeg D.J.; RT "Hepatic gene expression profiling using GeneChips in zebrafish exposed to RT 17alpha-methyldihydrotestosterone."; RL Aquat. Toxicol. 87:69-80(2008). RN [4] {ECO:0000313|EMBL:AAI65900.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65900.1}, and Whole RC {ECO:0000313|EMBL:AAH76513.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19515695; RA Weiser D.C., Row R.H., Kimelman D.; RT "Rho-regulated myosin phosphatase establishes the level of protrusive RT activity required for cell movements during zebrafish gastrulation."; RL Development 136:2375-2384(2009). RN [6] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22056673; RA Trinh le A., Hochgreb T., Graham M., Wu D., Ruf-Zamojski F., Jayasena C.S., RA Saxena A., Hawk R., Gonzalez-Serricchio A., Dixson A., Chow E., RA Gonzales C., Leung H.Y., Solomon I., Bronner-Fraser M., Megason S.G., RA Fraser S.E.; RT "A versatile gene trap to visualize and interrogate the function of the RT vertebrate proteome."; RL Genes Dev. 25:2306-2320(2011). RN [7] {ECO:0000313|Ensembl:ENSDARP00000039826} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039826}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [8] {ECO:0000313|Ensembl:ENSDARP00000039826} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039826}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [9] {ECO:0000313|Ensembl:ENSDARP00000113436} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000113436}; RG Ensembl; RL Submitted (AUG-2013) to UniProtKB. RN [10] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [11] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27189481; RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I., RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y., RA Bobe J.; RT "Gene evolution and gene expression after whole genome duplication in fish: RT the PhyloFish database."; RL BMC Genomics 17:368-368(2016). RN [12] {ECO:0000313|RefSeq:NP_001002692.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (JAN-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the PP1 inhibitor family. CC {ECO:0000256|ARBA:ARBA00005483}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL772136; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC076513; AAH76513.1; -; mRNA. DR EMBL; BC165900; AAI65900.1; -; mRNA. DR RefSeq; NP_001002692.1; NM_001002692.1. DR STRING; 7955.ENSDARP00000113436; -. DR Ensembl; ENSDART00000039827.6; ENSDARP00000039826.5; ENSDARG00000030161.8. DR Ensembl; ENSDART00000145201.3; ENSDARP00000113436.1; ENSDARG00000030161.8. DR GeneID; 100000577; -. DR KEGG; dre:100000577; -. DR CTD; 100000577; -. DR ZFIN; ZDB-GENE-030616-595; ppp1r14bb. DR eggNOG; KOG0824; Eukaryota. DR HOGENOM; CLU_114155_1_0_1; -. DR OMA; GAGEASX; -. DR OrthoDB; 5321897at2759; -. DR TreeFam; TF105546; -. DR Proteomes; UP000000437; Chromosome 7. DR Bgee; ENSDARG00000030161; Expressed in tail bud paraxial mesoderm and 30 other tissues. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0042325; P:regulation of phosphorylation; IEA:InterPro. DR Gene3D; 1.10.150.220; CPI-17; 1. DR InterPro; IPR008025; CPI-17. DR InterPro; IPR036658; CPI-17_sf. DR PANTHER; PTHR16188; PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C; 1. DR PANTHER; PTHR16188:SF5; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14B; 1. DR Pfam; PF05361; PP1_inhibitor; 1. DR SUPFAM; SSF81790; Myosin phosphatase inhibitor 17kDa protein, CPI-17; 1. PE 2: Evidence at transcript level; KW Protein phosphatase inhibitor {ECO:0000256|ARBA:ARBA00023272}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT REGION 1..31 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..28 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 128 AA; 14908 MW; B53AEBBEBBE429B2 CRC64; MAAVTSPESS QQARVYFQTP TGSTEETETP VRKQGRVTVK YDRKELRKRL NLEEWIIDQL TDLYDCEEEA IPELEIDVDE LLDMENDVDR AARVKELLVD CYKPTEEFVA ELLDRIRGMQ KLSTPQKK //