ID Q7ZZ37_DANRE Unreviewed; 128 AA. AC Q7ZZ37; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 03-AUG-2022, entry version 122. DE SubName: Full=Ppp1r14b protein {ECO:0000313|EMBL:AAI65900.1}; DE SubName: Full=Protein phosphatase 1, regulatory (Inhibitor) subunit 14B {ECO:0000313|EMBL:AAH76513.1}; DE SubName: Full=protein phosphatase 1, regulatory (Inhibitor) subunit 14Bb {ECO:0000313|RefSeq:NP_001002692.1}; GN Name=wu:fc32d08 {ECO:0000313|RefSeq:NP_001002692.1}; GN Synonyms=plcb3n {ECO:0000313|RefSeq:NP_001002692.1}, ppp1r14b GN {ECO:0000313|EMBL:AAI65900.1, ECO:0000313|RefSeq:NP_001002692.1}, GN si:zc188c22.2 {ECO:0000313|RefSeq:NP_001002692.1}, si:zc194c5.1 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fa01d09 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fb59a08 GN {ECO:0000313|RefSeq:NP_001002692.1}, wu:fk27d06 GN {ECO:0000313|RefSeq:NP_001002692.1}, zgc:91822 GN {ECO:0000313|RefSeq:NP_001002692.1}; GN OrderedLocusNames=ppp1r14bb {ECO:0000313|RefSeq:NP_001002692.1, GN ECO:0000313|ZFIN:ZDB-GENE-030616-595}; GN ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-030616-595}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65900.1}; RN [1] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11116086; RA Woods I.G., Kelly P.D., Chu F., Ngo-Hazelett P., Yan Y.L., Huang H., RA Postlethwait J.H., Talbot W.S.; RT "A comparative map of the zebrafish genome."; RL Genome Res. 10:1903-1914(2000). RN [2] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16109975; RA Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R., RA Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.; RT "The zebrafish gene map defines ancestral vertebrate chromosomes."; RL Genome Res. 15:1307-1314(2005). RN [3] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18339436; RA Hoffmann J.L., Thomason R.G., Lee D.M., Brill J.L., Price B.B., Carr G.J., RA Versteeg D.J.; RT "Hepatic gene expression profiling using GeneChips in zebrafish exposed to RT 17alpha-methyldihydrotestosterone."; RL Aquat. Toxicol. 87:69-80(2008). RN [4] {ECO:0000313|EMBL:AAI65900.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65900.1}, and Whole RC {ECO:0000313|EMBL:AAH76513.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19515695; RA Weiser D.C., Row R.H., Kimelman D.; RT "Rho-regulated myosin phosphatase establishes the level of protrusive RT activity required for cell movements during zebrafish gastrulation."; RL Development 136:2375-2384(2009). RN [6] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22056673; RA Trinh le A., Hochgreb T., Graham M., Wu D., Ruf-Zamojski F., Jayasena C.S., RA Saxena A., Hawk R., Gonzalez-Serricchio A., Dixson A., Chow E., RA Gonzales C., Leung H.Y., Solomon I., Bronner-Fraser M., Megason S.G., RA Fraser S.E.; RT "A versatile gene trap to visualize and interrogate the function of the RT vertebrate proteome."; RL Genes Dev. 25:2306-2320(2011). RN [7] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [8] {ECO:0000313|RefSeq:NP_001002692.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27189481; RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I., RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y., RA Bobe J.; RT "Gene evolution and gene expression after whole genome duplication in fish: RT the PhyloFish database."; RL BMC Genomics 17:368-368(2016). RN [9] {ECO:0000313|RefSeq:NP_001002692.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- SIMILARITY: Belongs to the PP1 inhibitor family. CC {ECO:0000256|ARBA:ARBA00005483}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC076513; AAH76513.1; -; mRNA. DR EMBL; BC165900; AAI65900.1; -; mRNA. DR RefSeq; NP_001002692.1; NM_001002692.1. DR STRING; 7955.ENSDARP00000113436; -. DR GeneID; 100000577; -. DR KEGG; dre:100000577; -. DR CTD; 100000577; -. DR ZFIN; ZDB-GENE-030616-595; ppp1r14bb. DR ZFIN; ZDB-GENE-030616-595; SO:0001217. DR eggNOG; KOG0824; Eukaryota. DR GeneTree; ENSGT00950000182985; -. DR HOGENOM; CLU_114155_1_0_1; -. DR OMA; CGVETMN; -. DR OrthoDB; 1492626at2759; -. DR TreeFam; TF105546; -. DR Proteomes; UP000000437; Chromosome 7. DR Bgee; ENSDARG00000030161; Expressed in tail bud paraxial mesoderm and 30 other tissues. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0042325; P:regulation of phosphorylation; IEA:InterPro. DR Gene3D; 1.10.150.220; -; 1. DR InterPro; IPR008025; CPI-17. DR InterPro; IPR036658; CPI-17_sf. DR PANTHER; PTHR16188; PTHR16188; 1. DR Pfam; PF05361; PP1_inhibitor; 1. DR SUPFAM; SSF81790; SSF81790; 1. PE 2: Evidence at transcript level; KW Protein phosphatase inhibitor {ECO:0000256|ARBA:ARBA00023272}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT REGION 1..31 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..28 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 128 AA; 14908 MW; B53AEBBEBBE429B2 CRC64; MAAVTSPESS QQARVYFQTP TGSTEETETP VRKQGRVTVK YDRKELRKRL NLEEWIIDQL TDLYDCEEEA IPELEIDVDE LLDMENDVDR AARVKELLVD CYKPTEEFVA ELLDRIRGMQ KLSTPQKK //