ID   Q7ZY26_XENLA            Unreviewed;       586 AA.
AC   Q7ZY26;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   12-OCT-2022, entry version 93.
DE   SubName: Full=Cbfa2t2 protein {ECO:0000313|EMBL:AAH44006.1};
DE   SubName: Full=protein CBFA2T2 {ECO:0000313|RefSeq:NP_001079526.1};
GN   Name=cbfa2t2.L {ECO:0000313|RefSeq:NP_001079526.1,
GN   ECO:0000313|Xenbase:XB-GENE-950038};
GN   Synonyms=cbfa2t2 {ECO:0000313|EMBL:AAH44006.1,
GN   ECO:0000313|RefSeq:NP_001079526.1}, cbfa2t2-a
GN   {ECO:0000313|RefSeq:NP_001079526.1}, MTGR1
GN   {ECO:0000313|RefSeq:NP_001079526.1}, XETOR
GN   {ECO:0000313|RefSeq:NP_001079526.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH44006.1};
RN   [1] {ECO:0000313|RefSeq:NP_001079526.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH44006.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH44006.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001079526.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15649458; DOI=10.1016/j.ydbio.2004.10.010;
RA   Koyano-Nakagawa N., Kintner C.;
RT   "The expression and function of MTG/ETO family proteins during
RT   neurogenesis.";
RL   Dev. Biol. 278:22-34(2005).
RN   [4] {ECO:0000313|RefSeq:NP_001079526.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
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DR   EMBL; BC044006; AAH44006.1; -; mRNA.
DR   RefSeq; NP_001079526.1; NM_001086057.1.
DR   DNASU; 379213; -.
DR   GeneID; 379213; -.
DR   KEGG; xla:379213; -.
DR   CTD; 379213; -.
DR   Xenbase; XB-GENE-950038; cbfa2t2.L.
DR   OrthoDB; 334242at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379213; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   Gene3D; 1.20.120.1110; -; 1.
DR   InterPro; IPR013289; CBFA2T1/2/3.
DR   InterPro; IPR013291; MTGR1.
DR   InterPro; IPR014896; NHR2.
DR   InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR   InterPro; IPR003894; TAFH_NHR1.
DR   InterPro; IPR002893; Znf_MYND.
DR   PANTHER; PTHR10379; PTHR10379; 1.
DR   Pfam; PF08788; NHR2; 1.
DR   Pfam; PF07531; TAFH; 1.
DR   Pfam; PF01753; zf-MYND; 1.
DR   PRINTS; PR01875; ETOFAMILY.
DR   PRINTS; PR01877; MTGR1PROTEIN.
DR   SMART; SM00549; TAFH; 1.
DR   SUPFAM; SSF158553; SSF158553; 1.
DR   PROSITE; PS51119; TAFH; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
DR   PROSITE; PS50865; ZF_MYND_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00134}.
FT   DOMAIN          102..197
FT                   /note="TAFH"
FT                   /evidence="ECO:0000259|PROSITE:PS51119"
FT   DOMAIN          497..533
FT                   /note="MYND-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50865"
FT   REGION          1..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..412
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  65069 MW;  B0C4B78A62F40774 CRC64;
     MVGIPGPYQF TGDKRVPAMP GSPMEVKIHS RSSPPIMAPL PPVNPGGLRP VGFPPSSHSN
     GINHSPPTLN GAPSPPQRSS NGPSSSSSSS LANQQLPATC GVRQLSKLKR FLTTLQQFGN
     DISPEIGEKV RTLVLALVNS TVTIEEFHCK LQEATNFPLR PFVIPFLKAN LPLLQRELLH
     CARAAKQTPS QYLAQHEHIL LNTSTSSPAD SSELLMELNG NGKRHSPDRR EEERETAPAE
     PPVKRVCTIS PAPRHSPALS LPLVNSTSHF HPTPPPLQHY SLEDIPSSQL YRDHLNKMGE
     HRDVRDRHHS SGVNGNLNNG YQEELVDHRL TEREWAEEWK HLDHALNCIM EMVEKTRRSM
     AVLRRCQEVD RDELNYWKRR FNESNEIRKG SEHPSRQHSP SSTDSGASDS VRDFGSRTGA
     GYVTDEIWRK AEEAVNEVKR QAMSEVQKAV SEAEQKAFEM IASERARMEQ TIVDAKRRAA
     EDAVLVVNEQ EESTESCWNC GRKASETCSG CNIARYCGSF CQHKDWEKHH RICGQSMHTQ
     AKPLTPSRSL IPKASDPVLL SPTLERSSSA TSRSSTPASV TAVDGL
//