ID   CF120_HUMAN             Reviewed;         191 AA.
AC   Q7Z4R8; B4DHE9; E1P5C9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   08-NOV-2023, entry version 134.
DE   RecName: Full=UPF0669 protein C6orf120;
DE   Flags: Precursor;
GN   Name=C6orf120;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RA   Zan Q., Guo J.H., Yu L.;
RL   Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of multiple
RT   enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
RN   [7]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=22340178;
RA   Li X., Qiao Y., Chang L.S., Xiao F., Lu L.H., Hao X.H., Zhang R.W., Wu H.,
RA   Wei H.S.;
RT   "Role of C6ORF120, an N-glycosylated protein, is implicated in apoptosis of
RT   CD4+ T lymphocytes.";
RL   Chin. Med. J. 124:3560-3567(2011).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- FUNCTION: May be involved in induction of apoptosis in CD4(+) T-cells,
CC       but not CD8(+) T-cells or hepatocytes. {ECO:0000269|PubMed:22340178}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22340178}.
CC       Note=Secreted by hepatocytes.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in hepatocytes and some weak
CC       expression in germinal center cells of lymph nodes.
CC       {ECO:0000269|PubMed:22340178}.
CC   -!- SIMILARITY: Belongs to the UPF0669 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF451991; AAP97690.1; -; mRNA.
DR   EMBL; AK295061; BAG58110.1; -; mRNA.
DR   EMBL; AL513547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW47445.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47446.1; -; Genomic_DNA.
DR   EMBL; BC051700; AAH51700.1; -; mRNA.
DR   CCDS; CCDS34575.1; -.
DR   RefSeq; NP_001025034.1; NM_001029863.2.
DR   RefSeq; NP_001304271.1; NM_001317342.1.
DR   AlphaFoldDB; Q7Z4R8; -.
DR   BioGRID; 132265; 37.
DR   IntAct; Q7Z4R8; 16.
DR   STRING; 9606.ENSP00000346931; -.
DR   GlyConnect; 1885; 1 N-Linked glycan (1 site).
DR   GlyCosmos; Q7Z4R8; 1 site, 1 glycan.
DR   GlyGen; Q7Z4R8; 1 site, 1 N-linked glycan (1 site).
DR   iPTMnet; Q7Z4R8; -.
DR   PhosphoSitePlus; Q7Z4R8; -.
DR   BioMuta; C6orf120; -.
DR   EPD; Q7Z4R8; -.
DR   jPOST; Q7Z4R8; -.
DR   MassIVE; Q7Z4R8; -.
DR   MaxQB; Q7Z4R8; -.
DR   PaxDb; 9606-ENSP00000346931; -.
DR   PeptideAtlas; Q7Z4R8; -.
DR   ProteomicsDB; 69225; -.
DR   Pumba; Q7Z4R8; -.
DR   Antibodypedia; 49519; 73 antibodies from 11 providers.
DR   DNASU; 387263; -.
DR   Ensembl; ENST00000332290.4; ENSP00000346931.1; ENSG00000185127.7.
DR   GeneID; 387263; -.
DR   KEGG; hsa:387263; -.
DR   MANE-Select; ENST00000332290.4; ENSP00000346931.1; NM_001029863.3; NP_001025034.1.
DR   UCSC; uc003qxb.4; human.
DR   AGR; HGNC:21247; -.
DR   CTD; 387263; -.
DR   DisGeNET; 387263; -.
DR   GeneCards; C6orf120; -.
DR   HGNC; HGNC:21247; C6orf120.
DR   HPA; ENSG00000185127; Low tissue specificity.
DR   MIM; 616987; gene.
DR   neXtProt; NX_Q7Z4R8; -.
DR   OpenTargets; ENSG00000185127; -.
DR   PharmGKB; PA134992326; -.
DR   VEuPathDB; HostDB:ENSG00000185127; -.
DR   eggNOG; ENOG502RXJP; Eukaryota.
DR   GeneTree; ENSGT00390000018879; -.
DR   HOGENOM; CLU_113576_1_0_1; -.
DR   InParanoid; Q7Z4R8; -.
DR   OMA; ESIFWTI; -.
DR   OrthoDB; 2967559at2759; -.
DR   PhylomeDB; Q7Z4R8; -.
DR   TreeFam; TF331743; -.
DR   PathwayCommons; Q7Z4R8; -.
DR   Reactome; R-HSA-6798695; Neutrophil degranulation.
DR   SignaLink; Q7Z4R8; -.
DR   BioGRID-ORCS; 387263; 9 hits in 1148 CRISPR screens.
DR   ChiTaRS; C6orf120; human.
DR   GenomeRNAi; 387263; -.
DR   Pharos; Q7Z4R8; Tdark.
DR   PRO; PR:Q7Z4R8; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q7Z4R8; Protein.
DR   Bgee; ENSG00000185127; Expressed in decidua and 204 other tissues.
DR   Genevisible; Q7Z4R8; HS.
DR   GO; GO:0035578; C:azurophil granule lumen; TAS:Reactome.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031420; UPF0669.
DR   PANTHER; PTHR31703; UPF0669 PROTEIN C6ORF120; 1.
DR   PANTHER; PTHR31703:SF2; UPF0669 PROTEIN C6ORF120; 1.
DR   Pfam; PF17065; UPF0669; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..191
FT                   /note="UPF0669 protein C6orf120"
FT                   /id="PRO_0000297662"
FT   CARBOHYD        53
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
SQ   SEQUENCE   191 AA;  20772 MW;  1B6B50EDFA54A9AD CRC64;
     MAAPRGRAAP WTTALLLLLA SQVLSPGSCA DEEEVPEEWV LLHVVQGQIG AGNYSYLRLN
     HEGKIVLRMR SLKGDADLYV SASSLHPSFD DYELQSATCG PDAVSIPAHF RRPVGIGVYG
     HPSHLESEFE MKVYYDGTVE QHPFGEAAYP ADGADAGQKH AGAPEDASQE EESVLWTILI
     SILKLVLEIL F
//