ID   LFG1_HUMAN              Reviewed;         371 AA.
AC   Q7Z429; B3KXM7; O43836; Q8IVW7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   23-FEB-2022, entry version 140.
DE   RecName: Full=Protein lifeguard 1;
DE   AltName: Full=Glutamate [NMDA] receptor-associated protein 1;
DE   AltName: Full=NMDA receptor glutamate-binding subunit;
DE   AltName: Full=Putative MAPK-activating protein PM02;
DE   AltName: Full=Transmembrane BAX inhibitor motif-containing protein 3;
GN   Name=GRINA; Synonyms=LFG1, NMDARA1, TMBIM3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA   Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y.,
RA   Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.;
RT   "Large-scale identification and characterization of human genes that
RT   activate NF-kappaB and MAPK signaling pathways.";
RL   Oncogene 22:3307-3318(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-107.
RC   TISSUE=Pancreas, and Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 218-371.
RC   TISSUE=Liver;
RA   Won M., Moon K.-M., Lee C.-E., Yoo H.S.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=8406459; DOI=10.1006/geno.1993.1311;
RA   Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W.,
RA   Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R.;
RT   "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA
RT   receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and
RT   chromosome 8, respectively.";
RL   Genomics 17:237-239(1993).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19784873; DOI=10.1007/s10495-009-0402-2;
RA   Hu L., Smith T.F., Goldberger G.;
RT   "LFG: a candidate apoptosis regulatory gene family.";
RL   Apoptosis 14:1255-1265(2009).
CC   -!- FUNCTION: Potential apoptotic regulator.
CC   -!- INTERACTION:
CC       Q7Z429; Q01740: FMO1; NbExp=3; IntAct=EBI-2832909, EBI-12701460;
CC       Q7Z429; Q6P531: GGT6; NbExp=3; IntAct=EBI-2832909, EBI-2868927;
CC       Q7Z429; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2832909, EBI-11721746;
CC       Q7Z429; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-2832909, EBI-1048945;
CC       Q7Z429; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-2832909, EBI-11962084;
CC       Q7Z429; Q01085-2: TIAL1; NbExp=3; IntAct=EBI-2832909, EBI-11064654;
CC       Q7Z429; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-2832909, EBI-10315004;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB94292.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB097026; BAC77379.1; -; mRNA.
DR   EMBL; AK127640; BAG54539.1; -; mRNA.
DR   EMBL; CH471416; EAW52305.1; -; Genomic_DNA.
DR   EMBL; BC041788; AAH41788.2; -; mRNA.
DR   EMBL; BC084553; AAH84553.1; -; mRNA.
DR   EMBL; U44954; AAB94292.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS34961.1; -.
DR   RefSeq; NP_000828.1; NM_000837.1.
DR   RefSeq; NP_001009184.1; NM_001009184.1.
DR   BioGRID; 109164; 11.
DR   DIP; DIP-47262N; -.
DR   IntAct; Q7Z429; 11.
DR   MINT; Q7Z429; -.
DR   STRING; 9606.ENSP00000314380; -.
DR   TCDB; 1.A.14.3.14; the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family.
DR   iPTMnet; Q7Z429; -.
DR   PhosphoSitePlus; Q7Z429; -.
DR   BioMuta; GRINA; -.
DR   DMDM; 74738689; -.
DR   EPD; Q7Z429; -.
DR   MassIVE; Q7Z429; -.
DR   PaxDb; Q7Z429; -.
DR   PeptideAtlas; Q7Z429; -.
DR   PRIDE; Q7Z429; -.
DR   ProteomicsDB; 69135; -.
DR   TopDownProteomics; Q7Z429; -.
DR   Antibodypedia; 48337; 198 antibodies from 23 providers.
DR   DNASU; 2907; -.
DR   Ensembl; ENST00000313269; ENSP00000314380; ENSG00000178719.
DR   Ensembl; ENST00000395068; ENSP00000378507; ENSG00000178719.
DR   GeneID; 2907; -.
DR   KEGG; hsa:2907; -.
DR   MANE-Select; ENST00000395068.9; ENSP00000378507.4; NM_001009184.2; NP_001009184.1.
DR   UCSC; uc003zan.2; human.
DR   CTD; 2907; -.
DR   DisGeNET; 2907; -.
DR   GeneCards; GRINA; -.
DR   HGNC; HGNC:4589; GRINA.
DR   HPA; ENSG00000178719; Low tissue specificity.
DR   MIM; 138251; gene.
DR   neXtProt; NX_Q7Z429; -.
DR   OpenTargets; ENSG00000178719; -.
DR   PharmGKB; PA28985; -.
DR   VEuPathDB; HostDB:ENSG00000178719; -.
DR   eggNOG; KOG2322; Eukaryota.
DR   GeneTree; ENSGT01030000234603; -.
DR   HOGENOM; CLU_058671_3_0_1; -.
DR   InParanoid; Q7Z429; -.
DR   OMA; GKFGEQS; -.
DR   OrthoDB; 1290306at2759; -.
DR   PhylomeDB; Q7Z429; -.
DR   TreeFam; TF319996; -.
DR   PathwayCommons; Q7Z429; -.
DR   SignaLink; Q7Z429; -.
DR   BioGRID-ORCS; 2907; 4 hits in 1043 CRISPR screens.
DR   ChiTaRS; GRINA; human.
DR   GenomeRNAi; 2907; -.
DR   Pharos; Q7Z429; Tbio.
DR   PRO; PR:Q7Z429; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q7Z429; protein.
DR   Bgee; ENSG00000178719; Expressed in right hemisphere of cerebellum and 230 other tissues.
DR   ExpressionAtlas; Q7Z429; baseline and differential.
DR   Genevisible; Q7Z429; HS.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..371
FT                   /note="Protein lifeguard 1"
FT                   /id="PRO_0000314439"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..118
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         107
FT                   /note="S -> N (in dbSNP:rs17854152)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037875"
FT   CONFLICT        224
FT                   /note="H -> R (in Ref. 5; AAB94292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        317
FT                   /note="A -> P (in Ref. 5; AAB94292)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        332..336
FT                   /note="LGNKQ -> REQA (in Ref. 5; AAB94292)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   371 AA;  41203 MW;  62E012DFB0E7DEEB CRC64;
     MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG
     PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF
     PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV
     SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY
     MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
     IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL
     YILTIIGRAK E
//