ID CXI6_CONRA STANDARD; PRT; 46 AA. AC Q7Z094; DT 29-MAR-2004 (Rel. 43, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE I-superfamily conotoxin R11.6 (r11a). OS Conus radiatus (Rayed cone). OC Eukaryota; Metazoa; Mollusca; Gastropoda; Orthogastropoda; OC Apogastropoda; Caenogastropoda; Sorbeoconcha; Hypsogastropoda; OC Neogastropoda; Conoidea; Conidae; Conus. OX NCBI_TaxID=61198; RN [1] RP SEQUENCE FROM N.A., SEQUENCE, AND MASS SPECTROMETRY. RC TISSUE=Venom, and Venom duct; RX PubMed=12694387; RA Jimenez E.C., Shetty R.P., Lirazan M., Rivier J., Walker C., RA Abogadie F.C., Yoshikami D., Cruz L.J., Olivera B.M.; RT "Novel excitatory Conus peptides define a new conotoxin superfamily."; RL J. Neurochem. 85:610-621(2003). CC -!- FUNCTION: Produces general excitatory symptoms upon intracorporeal CC injection and repetitive action potentials in the frog cutaneus CC pectoris muscle. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the venom duct. CC -!- PTM: Contains four disulfide bonds. CC -!- MASS SPECTROMETRY: MW=3816.7; METHOD=LSI; RANGE=1-46. CC -!- SIMILARITY: Belongs to the conotoxin I-superfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY208959; AAP41541.1; -. KW Toxin; Neurotoxin; Bromination; Hydroxylation; KW Direct protein sequencing. FT MOD_RES 2 2 Hydroxyproline (partial). FT MOD_RES 11 11 Hydroxyproline (partial). FT MOD_RES 29 29 Hydroxyproline. FT MOD_RES 33 33 6'-bromotryptophan. SQ SEQUENCE 46 AA; 4936 MW; 32C2812A24D82675 CRC64; GPSFCKADEK PCEYHADCCN CCLSGICAPS TNWILPGCST SSFFKI //