ID CXI6_CONRA Reviewed; 46 AA. AC Q7Z094; DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 28-NOV-2006, entry version 22. DE I-superfamily conotoxin r11a (R11.6). OS Conus radiatus (Rayed cone). OC Eukaryota; Metazoa; Mollusca; Gastropoda; Orthogastropoda; OC Apogastropoda; Caenogastropoda; Sorbeoconcha; Hypsogastropoda; OC Neogastropoda; Conoidea; Conidae; Conus. OX NCBI_TaxID=61198; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE, AND MASS SPECTROMETRY. RC TISSUE=Venom, and Venom duct; RX PubMed=12694387; RA Jimenez E.C., Shetty R.P., Lirazan M., Rivier J., Walker C., RA Abogadie F.C., Yoshikami D., Cruz L.J., Olivera B.M.; RT "Novel excitatory Conus peptides define a new conotoxin superfamily."; RL J. Neurochem. 85:610-621(2003). RN [2] RP SYNTHESIS, AND D-AMINO ACID AT PHE-44. RC TISSUE=Venom; RX PubMed=15561705; DOI=10.1074/jbc.M405835200; RA Buczek O., Yoshikami D., Bulaj G., Jimenez E.C., Olivera B.M.; RT "Post-translational amino acid isomerization: a functionally important RT D-amino acid in an excitatory peptide."; RL J. Biol. Chem. 280:4247-4253(2005). CC -!- FUNCTION: Produces general excitatory symptoms upon intracorporeal CC injection and repetitive action potentials in the frog cutaneous CC pectoris muscle. Natural peptide (with D-Phe) is active on nerve, CC but not on muscle. Synthetic peptide (with L-Phe) is not active on CC both nerve and muscle. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Expressed by the venom duct. CC -!- PTM: Contains four disulfide bonds. CC -!- PTM: The natural D-Phe form of the peptide is more potent than the CC L-Phe form. CC -!- MASS SPECTROMETRY: MW=3816.7; METHOD=LSI; RANGE=1-46; NOTE=Ref.1. CC -!- SIMILARITY: Belongs to the conotoxin I1 superfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY208959; AAP41541.1; -; mRNA. DR InterPro; IPR013141; Conotoxin_I. DR InterPro; IPR012624; Toxin_19. DR Pfam; PF08088; Toxin_19; 1. DR PROSITE; PS60019; I_CONOTOXIN; 1. KW Bromination; D-amino acid; Direct protein sequencing; Hydroxylation; KW Neurotoxin; Toxin. FT CHAIN 1 46 I-superfamily conotoxin r11a. FT /FTId=PRO_0000086868. FT MOD_RES 2 2 Hydroxyproline (partial). FT MOD_RES 11 11 Hydroxyproline (partial). FT MOD_RES 29 29 Hydroxyproline. FT MOD_RES 33 33 6'-bromotryptophan. FT MOD_RES 44 44 D-phenylalanine. SQ SEQUENCE 46 AA; 4936 MW; 32C2812A24D82675 CRC64; GPSFCKADEK PCEYHADCCN CCLSGICAPS TNWILPGCST SSFFKI //