ID Q7YU22_DROME Unreviewed; 426 AA. AC Q7YU22; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 03-MAY-2023, entry version 118. DE SubName: Full=RE03865p {ECO:0000313|EMBL:AAQ22498.1}; GN Name=fkh {ECO:0000313|EMBL:AAQ22498.1, GN ECO:0000313|FlyBase:FBgn0000659}; GN ORFNames=CG10002 {ECO:0000313|FlyBase:FBgn0000659}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAQ22498.1}; RN [1] {ECO:0000313|EMBL:AAQ22498.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAQ22498.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A., RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00089}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT010029; AAQ22498.1; -; mRNA. DR AlphaFoldDB; Q7YU22; -. DR AGR; FB:FBgn0000659; -. DR FlyBase; FBgn0000659; fkh. DR VEuPathDB; VectorBase:FBgn0000659; -. DR HOGENOM; CLU_027910_4_1_1; -. DR ExpressionAtlas; Q7YU22; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR CDD; cd20041; FH_dFKH; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR047388; FH-like_dFKH. DR InterPro; IPR013638; Fork-head_N. DR InterPro; IPR001766; Fork_head_dom. DR InterPro; IPR018122; TF_fork_head_CS_1. DR InterPro; IPR030456; TF_fork_head_CS_2. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1. DR PANTHER; PTHR11829:SF380; PROTEIN FORK HEAD; 1. DR Pfam; PF00250; Forkhead; 1. DR Pfam; PF08430; Forkhead_N; 1. DR PRINTS; PR00053; FORKHEAD. DR SMART; SM00339; FH; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00657; FORK_HEAD_1; 1. DR PROSITE; PS00658; FORK_HEAD_2; 1. DR PROSITE; PS50039; FORK_HEAD_3; 1. PE 2: Evidence at transcript level; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}. FT DOMAIN 210..304 FT /note="Fork-head" FT /evidence="ECO:0000259|PROSITE:PS50039" FT DNA_BIND 210..304 FT /note="Fork-head" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089" FT REGION 1..62 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 175..205 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 309..359 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 339..353 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 426 AA; 45207 MW; 17536747B18E3DDF CRC64; MQKLYAEPPP SSAPVSMASS GGGGPPSGGG GGGGGGGGGG PPPPSNNNPN PTSNGGSMSP LARSAYTMNS MGLPVGGMSS VSPQAAATFS SSVLDSAAAV VSMSASMSAS MSASMNASMN GSMGAAAMNS MGGNCMTPSS MSYASMGSPL GNMGGCMAMS AASMSAAGLS GTYGAMPPGS REMETGSPNS LGRSRVDKPT TYRRSYTHAK PPYSYISLIT MAIQNNPTRM LALSEIYQFI MDLFPFYRQN QQRWQNSIRH SLSFNDCFVK IPRTPDKPGK GSFWTLHPDS GNMFENGCYL RRQKRFKDEK KEAIRQLHKS PSHSSLEATS PGKKDHEDSH HMHHHHHSRL DHHQHHKEAG GASIAGVNVL SAAHSKDAEA LAMLHANAEL CLSQQPQHVP THHHHQHHQL QQEELSAMMA NRCHRR //