ID Q7TSV8_MOUSE Unreviewed; 275 AA. AC Q7TSV8; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 04-FEB-2015, entry version 55. DE SubName: Full=Ace protein {ECO:0000313|EMBL:AAH52531.1}; DE Flags: Fragment; GN Name=Ace {ECO:0000313|EMBL:AAH52531.1, ECO:0000313|MGI:MGI:87874}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH52531.1}; RN [1] {ECO:0000313|EMBL:AAH52531.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=Czech II {ECO:0000313|EMBL:AAH52531.1}; RC TISSUE=Lung {ECO:0000313|EMBL:AAH52531.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|RuleBase:RU361144}; CC Note=Binds 1 zinc ion per subunit. CC {ECO:0000256|RuleBase:RU361144}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|RuleBase:RU361144}; CC Note=Binds 2 Zn(2+) ions per subunit. CC {ECO:0000256|RuleBase:RU361144}; CC -!- SIMILARITY: Belongs to the peptidase M2 family. CC {ECO:0000256|RuleBase:RU361144}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC052531; AAH52531.1; -; mRNA. DR UniGene; Mm.754; -. DR ProteinModelPortal; Q7TSV8; -. DR MGI; MGI:87874; Ace. DR HOVERGEN; HBG103676; -. DR Genevestigator; Q7TSV8; -. DR GO; GO:0005768; C:endosome; ISO:MGI. DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0070062; C:extracellular vesicular exosome; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; ISO:MGI. DR GO; GO:0003779; F:actin binding; ISO:MGI. DR GO; GO:0031711; F:bradykinin receptor binding; ISO:MGI. DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0031404; F:chloride ion binding; ISO:MGI. DR GO; GO:0008144; F:drug binding; ISO:MGI. DR GO; GO:0004175; F:endopeptidase activity; ISO:MGI. DR GO; GO:0008237; F:metallopeptidase activity; ISO:MGI. DR GO; GO:0008233; F:peptidase activity; IMP:MGI. DR GO; GO:0008241; F:peptidyl-dipeptidase activity; ISO:MGI. DR GO; GO:0008270; F:zinc ion binding; ISO:MGI. DR GO; GO:0050482; P:arachidonic acid secretion; ISO:MGI. DR GO; GO:0060047; P:heart contraction; IMP:MGI. DR GO; GO:0042447; P:hormone catabolic process; ISO:MGI. DR GO; GO:0001822; P:kidney development; IMP:MGI. DR GO; GO:0002446; P:neutrophil mediated immunity; IMP:MGI. DR GO; GO:0043171; P:peptide catabolic process; ISO:MGI. DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IMP:MGI. DR GO; GO:0007283; P:spermatogenesis; IMP:MGI. DR InterPro; IPR001548; Peptidase_M2. DR PANTHER; PTHR10514; PTHR10514; 1. DR Pfam; PF01401; Peptidase_M2; 1. DR PRINTS; PR00791; PEPDIPTASEA. PE 2: Evidence at transcript level; KW Carboxypeptidase {ECO:0000256|RuleBase:RU361144}; KW Glycoprotein {ECO:0000256|RuleBase:RU361144}; KW Hydrolase {ECO:0000256|RuleBase:RU361144}; KW Metal-binding {ECO:0000256|RuleBase:RU361144}; KW Metalloprotease {ECO:0000256|RuleBase:RU361144}; KW Protease {ECO:0000256|RuleBase:RU361144}; KW Zinc {ECO:0000256|RuleBase:RU361144}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAH52531.1}. SQ SEQUENCE 275 AA; 31580 MW; AEB59A8A27881999 CRC64; GTRNLLSTEG SGYEFDINFL MKMALDKIAF IPFSYLIDQW RWRVFDGSIT KENYNQEWWS LRLNYQGLCP PVPRSQGDFD PGSKFHVPAN VPYVRYFVSF IIQFQFHEAL CRAAGHTGPL HKCDIYQSKE AGKLLADAMK LGYSKPWPEA MKLITGQPNM SASAMMNYFK PLTEWLVTEN RRHGETLGWP EYNWAPNTAR AEGSTAESNR VNFLGLYLEP QQARVGQWVL LFLGVALLVA TVGLAHRLYN IRNHHSLRRP HRGPQFGSEV ELRHS //