ID Q7TNJ9_RAT Unreviewed; 731 AA. AC Q7TNJ9; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 14-DEC-2022, entry version 96. DE SubName: Full=Stonin {ECO:0000313|EMBL:AAQ17545.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAQ17545.1}; RN [1] {ECO:0000313|EMBL:AAQ17545.1} RP NUCLEOTIDE SEQUENCE. RA Stenson-Cox C., Gill C., Samali A.; RT "In silico cloning and characterization of rat stonin."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC -!- SIMILARITY: Belongs to the Stoned B family. CC {ECO:0000256|ARBA:ARBA00005579, ECO:0000256|PIRNR:PIRNR037099}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY300793; AAQ17545.1; -; mRNA. DR AlphaFoldDB; Q7TNJ9; -. DR IntAct; Q7TNJ9; 3. DR MINT; Q7TNJ9; -. DR UCSC; RGD:727878; rat. DR PhylomeDB; Q7TNJ9; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW. DR GO; GO:0030100; P:regulation of endocytosis; IEA:UniProtKB-UniRule. DR InterPro; IPR036168; AP2_Mu_C_sf. DR InterPro; IPR028565; MHD. DR InterPro; IPR012320; SHD_dom. DR InterPro; IPR031232; Ston1. DR InterPro; IPR017110; Stonin. DR PANTHER; PTHR10529:SF339; STONIN-1; 1. DR Pfam; PF00928; Adap_comp_sub; 1. DR PIRSF; PIRSF037099; Stonin; 3. DR SUPFAM; SSF49447; Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; 1. DR PROSITE; PS51072; MHD; 1. DR PROSITE; PS51070; SHD; 1. PE 2: Evidence at transcript level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Endocytosis {ECO:0000256|PIRNR:PIRNR037099}. FT DOMAIN 269..402 FT /note="SHD" FT /evidence="ECO:0000259|PROSITE:PS51070" FT DOMAIN 405..709 FT /note="MHD" FT /evidence="ECO:0000259|PROSITE:PS51072" FT REGION 40..83 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 109..162 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..66 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 129..152 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 731 AA; 81921 MW; 0901D042FF6E7566 CRC64; MCSTNPGSWV TFDDDSLFQS SPKKKDLSLE TQGVCRPNGL KLDLPGLRDL PNTPSSTGST PLSSPMVDFY FSPGPPSNSP LSTPTTDFPG FPGIPKAGTH VLYPIPECSS SSPPTTAGGA GPPLSLTKPT CSPHVSLPSG HSHTQLTPTA GLTEDASPRG VQSEARQFEY FQDDCAFSNP FWKDEGGNSQ FPFDSLASRK LFSPRDKEVP DDQKSLNQCS LNYICEKLEH LQSAETQDPL GNLSMQSSYA GGTFSFVPHT LFRSQPKAGW SFMLRIPEKK NMMSSRQWGP IFLKVLPGGI LQMYYEKGLE KPFKEFQLNP HCRLSEPKLE NFSMAGKIHT VKVEHVSYSE KRKYHSKVEV VHEPEVEQML KLGSTEHRDF LEFLTTVEEG KLPATAKPKN KIYEEQEIHL DILDSFWGKV TKEEGKLVES AVLTQVCCLC FLNGPAECFL ALNDLELQKR DERYFEKEPE KRGIDILNYH FHTCVNAEEF ERSRSLKFVP PDACRFELMR FRTSREGDEL PFSVKSIVTV QGAYVELQAF VNMTPAVQRS PHAGSLRSCN NIMIHFPVPA QWIKALWTRN LQRQKSLKAK MNRRACLGSL QGPELEPVIQ VTVGSAKYES AYRAVVWKID RLPDKNTSPD QPHCLSYKLE LGSDQEVPSD WDPFATVQFS MSEACASRTE VRSLGVESDA QPQKHVCQRA CYNIQVQVEI EKKWIQIDGE DPDKAGGCVT Q //