ID Q7TN88_MOUSE PRELIMINARY; PRT; 2461 AA. AC Q7TN88; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 04-APR-2006, entry version 16. DE Polycystic kidney disease 1-like 2. GN Name=Pkd1l2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6; TISSUE=Embryo; RX MEDLINE=22666619; PubMed=12782129; DOI=10.1016/S0888-7543(03)00048-X; RA Li A., Tian X., Sung S.-W., Somlo S.; RT "Identification of two novel polycystic kidney disease-1-like genes in RT human and mouse genomes."; RL Genomics 81:596-608(2003). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY164484; AAO32797.1; -; mRNA. DR UniGene; Mm.159753; -. DR HSSP; P22897; 1EGG. DR Ensembl; ENSMUSG00000034416; Mus musculus. DR MGI; MGI:2664668; Pkd1l2. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0016020; C:membrane; IEA. DR GO; GO:0005509; F:calcium ion binding; IEA. DR GO; GO:0005261; F:cation channel activity; IEA. DR GO; GO:0005529; F:sugar binding; IEA. DR GO; GO:0006812; P:cation transport; IEA. DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA. DR InterPro; IPR002111; Cat_channel_TrpL. DR InterPro; IPR000293; Channel_colicin. DR InterPro; IPR001304; Lectin_C. DR InterPro; IPR000922; Lectin_gal_bd. DR InterPro; IPR008976; Lipase_LipOase. DR InterPro; IPR001024; LipOase_LH2. DR InterPro; IPR005820; M+channel_nlg. DR InterPro; IPR013122; PKD1_2_channel. DR InterPro; IPR000434; PKD_1. DR InterPro; IPR003915; PKD_2. DR InterPro; IPR000203; PKD_cys_rich. DR Pfam; PF02140; Gal_Lectin; 1. DR Pfam; PF01825; GPS; 1. DR Pfam; PF00059; Lectin_C; 1. DR Pfam; PF08016; PKD_channel; 1. DR Pfam; PF01477; PLAT; 1. DR PRINTS; PR00500; POLYCYSTIN1. DR PRINTS; PR01433; POLYCYSTIN2. DR ProDom; PD005612; Gal_lectin; 1. DR SMART; SM00034; CLECT; 1. DR SMART; SM00303; GPS; 1. DR SMART; SM00308; LH2; 1. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. DR PROSITE; PS00276; CHANNEL_COLICIN; UNKNOWN_1. DR PROSITE; PS50221; GPS; 1. DR PROSITE; PS50095; PLAT; 1. DR PROSITE; PS50228; SUEL_LECTIN; 1. SQ SEQUENCE 2461 AA; 271977 MW; 5F837EBA57D54BF3 CRC64; MAGLVFLGLA LSSGATVAKS EGGSLCSRSQ VFFRDACYEF VPLEHTFPGA QGWCEGHGGH LAFIPDEDTQ QFLQRHITQD REWWIGLTGG SGHNGTVGGS GTWLDTSNVN YSNWQEGQAT PAPGSCGYIG SGPSSQWAAL EDCTQTFAFV CEFGVGRSLA CEGHNATMHC DSGEVILVQD AFYGHQTPYL CTRGIWPPSD LEGECGWVSV KDEVAGQCQG LQACQVAVDG TYFGDPCPTR GSYLWVQYQC LEGLRLVVPN GSFIFDNVTI SLMWLLSPYT GNLSCVLSMG DGYTFDPYNP PSVSSNVTHQ FSSPGEFTVF AECTTSEWHV TAQKQVILCE KVETPRITGC TGLAGAGVGL LCQAVFGEPL WVQVDLDGGA GATYAVLSHN RTLAEFTAQR GSQLYNLTLD RDIQEMLGPG RHHLKIQAVS NEGTGTASAP SGNFTVYFVE PLSGLRASWA SDRVELGWDL VVNVSVARGT LEELTFEVAG LNANFSQEEE SVGQSSGNYH VAVPAEGTFL VTVHVRNAFS ELSLDIGNIT VTASSSLQEL SGINAEAKSG HKQDMKVFTE PELYVDPFTE VTLGWPDDDP GLNFHWSCGR CWAQWNACVG RQLLHTDQRL LVLHTFCLPP LNSAVTLHLA ILRGQELEKE TEQCLYVSAP LNLGPQISCE KNCRPVKADQ DVLLTVTVGD ETSVAVFSWY LDDTVPEEVE PLPAACRLRG FWPRSLTLLH SNSSVLLLNS SFLQTWGPVI PIRVTALTSH AYGEDTYMIS MLPRPEVPAC TIDPEEGSVL TSFTVSCSTP ATLGPVEYCF CLPSGFCLHC GPEPALPAVY LPLGEEKDGF VLPVVISVTN RAGDIEQTQV AVKVGHSYTG VEDVTFQEMV SERIATALHQ ESGREQLLLF AKAVSSELNS EVQSPGSGQL GMDIKRKVRE LMLRSLSVVT TGLQNMQRVQ ALAEVLREVT QRAEELTPAA QWEASCALQR ATEALLVAST KVRPEDQRRQ EATRAMFEAV GSVLEASLSH RSEEPMEANS SQVAYIVAQL LRVIDHFQSA LLLGTLPGGL PAILVTPSIS VYTDRIQPRS WQGSSVHTAA ADSVTFTLPA ATFLCPMEDS QEPVDIRMMS FSQNPFPSRS QFDVSGTVGG LRLTSSSGHP IPVKNLSQNI EILLPRISAH IEPKMLSLAS REALSVNVTA GDTALGIQLH WGPGVPLILS LGYGYHPNET SYDAQTHLPP VAATGDLPTW ILHPEDLPFG EGVYYLRVVP EADLESSSGR NLTVGITTFL AHCVFWDETQ ETWDDSGCQV GPRTTPSQTH CLCNHLTFFG SSFLVMPNAI DVRQTAELFA TFEDNPVVVT TVGCLCMLYV LVLIWARRKD IQDQAKVKVV VLEDNDPFAQ YHYLVTVYTG HRRGAATSSK VTLTLYGSDG ESEPHHLSDP DAAVFERGGV DVFLLSTLFP LGELQSLRLW HDNSGDRPSW YVSRVLVYDS VVDRKWYFLC NSWLSVDVGD CVLDKVFPVA TEQDRKQFSH LFFTKTSTGF QDGHIWYSVF CSATRSSFTR VQRVSCCFSM LLCTMLTSIM FWGVPKDPAE QKMDLGKIEF TWQEVMIGLE SSILMFPINL LIVQIFRNTR PRLPMGKDGR QKQGPPNLTP SAQPTEEGLL TPETGIQSLI SSLFKALKVQ PPASGWDSMN PVDINYLLTL MEDIICPEST EGPGFWEEAK GREDPITSTR GSVKPKENTW HPKPELAVRG LWKDSVYRRC LYLQLEHVER ELQLLGPQGF LHHHSHAQAL RQLHVLKGHL WGQPGTPALA YPSTSRVSKS PRGLPWWCVL VGWLLVATTS GVAAFFTMLY GLHYGRVSSL KWLISMAVSF VESVFITQPL KVLGFAAFFA LVLKREDDEE TLPLFPGHLS SPGPGVLFRS RRHSSERAYQ PPPMAAIEKM KTTRLKEQKA FALIREILAY LAFLWMLLLV AYGQRDPNAY HFHRHLERSF SQGFSPVLGF RGFFEWANTT LVKNLYGHHP GFVTDGNSKL VGSAHIRQVR VRESSCAVAQ QLQDSLDGCH GPYSLGIEDL VDYGEGWNAS AYNNSNGFPQ AWRYQSQSQR RGYPMWGKLT LYGGGGYVVP LGTDHQSASR ILQYLFDNSW LDALTRAVFV EFTVYNANVN LFCTVTLTLE TSGLGTFFSH VTLQSLRLYP FTDGWHPFVV AAELTYFLFL FYYMVVQGKL MRKQKWGYFC SKWNLLEVAI ILASWSALVV FVKRTILADR DLQRYREHRE GISFSETAAA DAALGYIIAF LVLLSTVKLW HLLRLNPKMN MITSALRRAW GDISGFVAVI LIMLLAYSFA SNLVFGWKLR SYKTLFDAAE TMVSLQLGIF NYEEVLDYSP ILGSLLIGSC IVFMTFVVLN LFISVILVAF SEEQKSDQLS EEGEIADLLL VKILSFLGIR CKREETWSSS EQPELPPQAL APQPAQALSR V //