ID Q7TMV8_MOUSE Unreviewed; 380 AA. AC Q7TMV8; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 28-JUN-2023, entry version 89. DE SubName: Full=Mpa2l protein {ECO:0000313|EMBL:AAH52867.1}; DE Flags: Fragment; GN Name=Gbp6 {ECO:0000313|MGI:MGI:2140937}; GN Synonyms=Mpa2l {ECO:0000313|EMBL:AAH52867.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH52867.1}; RN [1] {ECO:0000313|EMBL:AAH52867.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6NCr {ECO:0000313|EMBL:AAH52867.1}; RC TISSUE=Hematopoietic Stem Cell {ECO:0000313|EMBL:AAH52867.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase CC superfamily. GB1/RHD3 GTPase family. {ECO:0000256|PROSITE- CC ProRule:PRU01052}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC052867; AAH52867.1; -; mRNA. DR AlphaFoldDB; Q7TMV8; -. DR PeptideAtlas; Q7TMV8; -. DR AGR; MGI:2140937; -. DR MGI; MGI:2140937; Gbp6. DR ChiTaRS; Gbp6; mouse. DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt. DR GO; GO:0005525; F:GTP binding; IEA:InterPro. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0071346; P:cellular response to type II interferon; IEA:UniProt. DR GO; GO:0009617; P:response to bacterium; IEA:UniProt. DR CDD; cd16269; GBP_C; 1. DR Gene3D; 1.20.1000.10; Guanylate-binding protein, C-terminal domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR030386; G_GB1_RHD3_dom. DR InterPro; IPR037684; GBP_C. DR InterPro; IPR003191; Guanylate-bd/ATL_C. DR InterPro; IPR036543; Guanylate-bd_C_sf. DR InterPro; IPR015894; Guanylate-bd_N. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR10751; GUANYLATE BINDING PROTEIN; 1. DR PANTHER; PTHR10751:SF114; GUANYLATE BINDING PROTEIN 11-RELATED; 1. DR Pfam; PF02263; GBP; 1. DR Pfam; PF02841; GBP_C; 1. DR SUPFAM; SSF48340; Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; 1. DR PROSITE; PS51715; G_GB1_RHD3; 1. PE 2: Evidence at transcript level; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Innate immunity {ECO:0000256|ARBA:ARBA00022588}. FT DOMAIN 1..44 FT /note="GB1/RHD3-type G" FT /evidence="ECO:0000259|PROSITE:PS51715" FT REGION 267..291 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAH52867.1" SQ SEQUENCE 380 AA; 44287 MW; 7799E5F13BFE1CA6 CRC64; RGNPRPTHDK ELLQKLDSIT EDQLDPKFQE VTKAFVSYIF TYAKIKTLKE GIKVTGNRLG ILVTTYVNAI NSGAVPCLDD AVTTLAQREN SVAVQKAADH YSEQMAQRLR LPTETLQELL DVHAACEKEA MAVFMEHSFK DENQQFLKKL VELIGENKEL FLSKNEEASN KYCQEELDRL SKDFMENIST FFVPCGHKLY MDKREKIEHD YWQVPRKGVK ASEVFQSFLQ SQAFIESSIL QADTALTAGE KAIAEERAQK VAAEKEQELL RQKQKEQQEH MEAQEKSHKE NLEQLRRKLE QEREQDIKDH DMMLKKLMKD QKAFLEEGFK KKAEEMNKEI QQLRDVIKDK KRNTDRIKEA LLNGFSTVLF HYLVRYLKHL //