ID Q7TMI9_MOUSE Unreviewed; 435 AA. AC Q7TMI9; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 01-OCT-2014, entry version 57. DE SubName: Full=Axin1 protein {ECO:0000313|EMBL:AAH55491.1}; DE Flags: Fragment {ECO:0000313|EMBL:AAH55491.1}; GN Name=Axin1 {ECO:0000313|EMBL:AAH55491.1, ECO:0000313|MGI:MGI:1096327}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH55491.1}; RN [1] {ECO:0000313|EMBL:AAH55491.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N {ECO:0000313|EMBL:AAH55491.1}; RC TISSUE=Mammary tumor. C3 {ECO:0000313|EMBL:AAH55491.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055491; AAH55491.1; -; mRNA. DR UniGene; Mm.23684; -. DR STRING; 10090.ENSMUSP00000073974; -. DR MGI; MGI:1096327; Axin1. DR HOVERGEN; HBG004324; -. DR Bgee; Q7TMI9; -. DR Genevestigator; Q7TMI9; -. DR GO; GO:0030877; C:beta-catenin destruction complex; IDA:MGI. DR GO; GO:0005938; C:cell cortex; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0014069; C:postsynaptic density; IBA:RefGenome. DR GO; GO:0043234; C:protein complex; IDA:MGI. DR GO; GO:0070016; F:armadillo repeat domain binding; IBA:RefGenome. DR GO; GO:0008013; F:beta-catenin binding; IMP:MGI. DR GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome. DR GO; GO:0070411; F:I-SMAD binding; IPI:MGI. DR GO; GO:0042802; F:identical protein binding; IPI:MGI. DR GO; GO:0002039; F:p53 binding; IPI:MGI. DR GO; GO:0005515; F:protein binding; IPI:MGI. DR GO; GO:0008022; F:protein C-terminus binding; IDA:MGI. DR GO; GO:0019904; F:protein domain specific binding; IPI:MGI. DR GO; GO:0042803; F:protein homodimerization activity; IPI:MGI. DR GO; GO:0019901; F:protein kinase binding; IPI:MGI. DR GO; GO:0043621; F:protein self-association; IPI:MGI. DR GO; GO:0070412; F:R-SMAD binding; IPI:MGI. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:MGI. DR GO; GO:0007257; P:activation of JUN kinase activity; IBA:RefGenome. DR GO; GO:0048318; P:axial mesoderm development; IMP:MGI. DR GO; GO:0048320; P:axial mesoderm formation; IMP:MGI. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:MGI. DR GO; GO:0060823; P:canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; IBA:RefGenome. DR GO; GO:0008219; P:cell death; IBA:RefGenome. DR GO; GO:0071407; P:cellular response to organic cyclic compound; IBA:RefGenome. DR GO; GO:0031122; P:cytoplasmic microtubule organization; IGI:MGI. DR GO; GO:0007368; P:determination of left/right symmetry; IBA:RefGenome. DR GO; GO:0009950; P:dorsal/ventral axis specification; IDA:MGI. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0048048; P:embryonic eye morphogenesis; IBA:RefGenome. DR GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IBA:RefGenome. DR GO; GO:0071514; P:genetic imprinting; IMP:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0055001; P:muscle cell development; IBA:RefGenome. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:MGI. DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IDA:MGI. DR GO; GO:0051248; P:negative regulation of protein metabolic process; IDA:MGI. DR GO; GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:MGI. DR GO; GO:0006913; P:nucleocytoplasmic transport; IDA:MGI. DR GO; GO:0030910; P:olfactory placode formation; IBA:RefGenome. DR GO; GO:0001743; P:optic placode formation; IBA:RefGenome. DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GOC. DR GO; GO:0046330; P:positive regulation of JNK cascade; IMP:MGI. DR GO; GO:0043507; P:positive regulation of JUN kinase activity; IDA:MGI. DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI. DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:MGI. DR GO; GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI. DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:MGI. DR GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI. DR GO; GO:0030163; P:protein catabolic process; IDA:MGI. DR GO; GO:0051260; P:protein homooligomerization; IDA:MGI. DR GO; GO:0000209; P:protein polyubiquitination; IDA:MGI. DR GO; GO:0035412; P:regulation of catenin import into nucleus; IDA:MGI. DR GO; GO:0001932; P:regulation of protein phosphorylation; IGI:MGI. DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI. DR GO; GO:0016055; P:Wnt signaling pathway; IDA:MGI. DR GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IBA:RefGenome. DR GO; GO:0021881; P:Wnt-activated signaling pathway involved in forebrain neuron fate commitment; IBA:RefGenome. DR InterPro; IPR014936; Axin_b-cat-bd. DR InterPro; IPR001158; DIX. DR InterPro; IPR029071; Ubiquitin-rel_dom. DR Pfam; PF08833; Axin_b-cat_bind; 1. DR Pfam; PF00778; DIX; 1. DR SMART; SM00021; DAX; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR PROSITE; PS50841; DIX; 1. PE 2: Evidence at transcript level; FT NON_TER 1 1 {ECO:0000313|EMBL:AAH55491.1}. SQ SEQUENCE 435 AA; 48456 MW; C8E468789A2A880C CRC64; IHRLEAVQRT REAEEKLEER LKRVRMEEEG EDGEMPSGPM ASHKLPSVPA WHHFPPRYVD MGCSGLRDAH EENPESILDE HVQRVMRTPG CQSPGPGHRS PDSGHVAKTA VLGGTASGHG KHVPKLGLKL DTAGLHHHRH VHHHVHHNSA RPKEQMEAEV ARRVQSSFSW GPETHGHAKP RSYSENAGTT LSAGDLAFGG KTSAPSKRNT KKAESGKNAN AEVPSTTEDA EKNQKIMQWI IEGEKEISRH RKAGHGSSGL RKQQAHESSR PLSIERPGAV HPWVSAQLRN SVQPSHLFIQ DPTMPPNPAP NPLTQLEEAR RRLEEEEKRA NKLPSKQRTK SQRKAGGGSA PPCDSIVVAY YFCGEPIPYR TLVRGRAVTL GQFKELLTKK GSYRYYFKKV SDEFDCGVVF EEVREDEAVL PVFEEKIIGK VEKVD //