ID Q7TMI9_MOUSE Unreviewed; 435 AA. AC Q7TMI9; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 31-MAY-2011, entry version 43. DE SubName: Full=Axin1 protein; DE Flags: Fragment; GN Name=Axin1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary tumor. C3; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055491; AAH55491.1; -; mRNA. DR IPI; IPI00875849; -. DR UniGene; Mm.23684; -. DR HSSP; Q9YGY0; 1QZ7. DR STRING; Q7TMI9; -. DR MGI; MGI:1096327; Axin1. DR GeneTree; ENSGT00390000010011; -. DR HOVERGEN; HBG004324; -. DR ArrayExpress; Q7TMI9; -. DR Bgee; Q7TMI9; -. DR Genevestigator; Q7TMI9; -. DR GO; GO:0034747; C:Axin-APC-beta-catenin-GSK3B complex; IDA:MGI. DR GO; GO:0005938; C:cell cortex; IDA:MGI. DR GO; GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI. DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:MGI. DR GO; GO:0044459; C:plasma membrane part; IDA:MGI. DR GO; GO:0005625; C:soluble fraction; IDA:MGI. DR GO; GO:0008013; F:beta-catenin binding; IMP:MGI. DR GO; GO:0070411; F:I-SMAD binding; IPI:MGI. DR GO; GO:0008022; F:protein C-terminus binding; IDA:MGI. DR GO; GO:0019904; F:protein domain specific binding; IPI:MGI. DR GO; GO:0042803; F:protein homodimerization activity; IPI:MGI. DR GO; GO:0019901; F:protein kinase binding; IPI:MGI. DR GO; GO:0043621; F:protein self-association; IPI:MGI. DR GO; GO:0070412; F:R-SMAD binding; IPI:MGI. DR GO; GO:0004871; F:signal transducer activity; IEA:InterPro. DR GO; GO:0016566; F:specific transcriptional repressor activity; IDA:MGI. DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:MGI. DR GO; GO:0048320; P:axial mesoderm formation; IMP:MGI. DR GO; GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI. DR GO; GO:0031122; P:cytoplasmic microtubule organization; IGI:MGI. DR GO; GO:0009950; P:dorsal/ventral axis specification; IDA:MGI. DR GO; GO:0071514; P:genetic imprinting; IMP:MGI. DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI. DR GO; GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:MGI. DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IDA:MGI. DR GO; GO:0090041; P:negative regulation of gene-specific transcription elongation from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0051248; P:negative regulation of protein metabolic process; IDA:MGI. DR GO; GO:0006913; P:nucleocytoplasmic transport; IDA:MGI. DR GO; GO:0046330; P:positive regulation of JNK cascade; IMP:MGI. DR GO; GO:0043507; P:positive regulation of JUN kinase activity; IMP:MGI. DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI. DR GO; GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI. DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:MGI. DR GO; GO:0030163; P:protein catabolic process; IDA:MGI. DR GO; GO:0051260; P:protein homooligomerization; IDA:MGI. DR GO; GO:0000209; P:protein polyubiquitination; IDA:MGI. DR GO; GO:0035412; P:regulation of catenin import into nucleus; IDA:MGI. DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI. DR GO; GO:0035121; P:tail morphogenesis; IMP:MGI. DR InterPro; IPR014936; Axin_b-cat-bd. DR InterPro; IPR001158; DIX. DR Pfam; PF08833; Axin_b-cat_bind; 1. DR Pfam; PF00778; DIX; 1. DR SMART; SM00021; DAX; 1. DR PROSITE; PS50841; DIX; 1. PE 2: Evidence at transcript level; FT NON_TER 1 1 SQ SEQUENCE 435 AA; 48456 MW; C8E468789A2A880C CRC64; IHRLEAVQRT REAEEKLEER LKRVRMEEEG EDGEMPSGPM ASHKLPSVPA WHHFPPRYVD MGCSGLRDAH EENPESILDE HVQRVMRTPG CQSPGPGHRS PDSGHVAKTA VLGGTASGHG KHVPKLGLKL DTAGLHHHRH VHHHVHHNSA RPKEQMEAEV ARRVQSSFSW GPETHGHAKP RSYSENAGTT LSAGDLAFGG KTSAPSKRNT KKAESGKNAN AEVPSTTEDA EKNQKIMQWI IEGEKEISRH RKAGHGSSGL RKQQAHESSR PLSIERPGAV HPWVSAQLRN SVQPSHLFIQ DPTMPPNPAP NPLTQLEEAR RRLEEEEKRA NKLPSKQRTK SQRKAGGGSA PPCDSIVVAY YFCGEPIPYR TLVRGRAVTL GQFKELLTKK GSYRYYFKKV SDEFDCGVVF EEVREDEAVL PVFEEKIIGK VEKVD //