ID   Q7T1E0_DANRE            Unreviewed;       350 AA.
AC   Q7T1E0;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   26-NOV-2014, entry version 96.
DE   RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)] {ECO:0000256|RuleBase:RU361243};
DE            EC=1.1.1.8 {ECO:0000256|RuleBase:RU361243};
GN   Name=gpd1b {ECO:0000313|EMBL:AAH55382.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-3906};
GN   Synonyms=gpd1h {ECO:0000313|EMBL:ABG78033.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH55382.1};
RN   [1] {ECO:0000313|EMBL:AAH55382.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH55382.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAH67596.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH67596.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ABG78033.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Smith A.H., Chopra S.S., Roden D.M.;
RT   "Cloning gpd1h in adult zebrafish myocardium.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(+) = glycerone
CC       phosphate + NADH. {ECO:0000256|RuleBase:RU361243}.
CC   -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU000437}.
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DR   EMBL; BC055382; AAH55382.1; -; mRNA.
DR   EMBL; BC067596; AAH67596.1; -; mRNA.
DR   EMBL; DQ677583; ABG78033.1; -; mRNA.
DR   RefSeq; NP_956000.1; NM_199706.1.
DR   UniGene; Dr.79210; -.
DR   STRING; 7955.ENSDARP00000063394; -.
DR   GeneID; 325181; -.
DR   KEGG; dre:325181; -.
DR   CTD; 325181; -.
DR   ZFIN; ZDB-GENE-030131-3906; gpd1b.
DR   eggNOG; COG0240; -.
DR   HOGENOM; HOG000246855; -.
DR   HOVERGEN; HBG003669; -.
DR   KO; K00006; -.
DR   Reactome; REACT_181620; Synthesis of PA.
DR   Reactome; REACT_238155; Triglyceride Biosynthesis.
DR   NextBio; 20809156; -.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   Gene3D; 3.40.50.720; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR006168; G3P_DH_NAD-dep.
DR   InterPro; IPR006109; G3P_DH_NAD-dep_C.
DR   InterPro; IPR017751; G3P_DH_NAD-dep_euk.
DR   InterPro; IPR011128; G3P_DH_NAD-dep_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR11728; PTHR11728; 1.
DR   Pfam; PF07479; NAD_Gly3P_dh_C; 1.
DR   Pfam; PF01210; NAD_Gly3P_dh_N; 1.
DR   PIRSF; PIRSF000114; Glycerol-3-P_dh; 1.
DR   PRINTS; PR00077; GPDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   TIGRFAMs; TIGR03376; glycerol3P_DH; 1.
DR   PROSITE; PS00957; NAD_G3PDH; 1.
PE   2: Evidence at transcript level;
KW   NAD {ECO:0000256|RuleBase:RU000437};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000437}.
FT   REGION      270    271       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR000114-2}.
FT   ACT_SITE    204    204       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000114-1}.
FT   BINDING     120    120       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000114-2}.
SQ   SEQUENCE   350 AA;  38194 MW;  6A124D0095BFFCD5 CRC64;
     MAAKKICIIG SGNWGSAIAK IVGANAAKYN TFENTVNMWV FEEMINGRKL TEIINTEHEN
     VKYLPGHKLP PNVLAVPDLL ESVKGADILI FVIPHQFVSR ICDTIKGHIK PDAVGMSLIK
     GVDEGPDGLK LISDVIREKL GITMTVLMGA NLANEVADEK FCETTIGCKS KPHGPLLKEL
     MQTQNFRVTV VEEADVVEIC GALKNIVAVG AGFCDGLSFG DNTKAAVIRL GLMEMIAFAR
     LFCTASPVSP ATFLESCGVA DLITTCYGGR NRKVGEAFAR TGKSIEELEK EMLNGQKLQG
     PATAAEVHQI LKHKNLVEKF PLFNAVYQIC FQNHPVKEFI MCLQNHPEHM
//