ID Q7T1E0_DANRE Unreviewed; 350 AA. AC Q7T1E0; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 01-APR-2015, entry version 100. DE RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)] {ECO:0000256|RuleBase:RU361243}; DE EC=1.1.1.8 {ECO:0000256|RuleBase:RU361243}; GN Name=gpd1b {ECO:0000313|EMBL:AAH55382.1, GN ECO:0000313|ZFIN:ZDB-GENE-030131-3906}; GN Synonyms=gpd1h {ECO:0000313|EMBL:ABG78033.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH55382.1}; RN [1] {ECO:0000313|EMBL:AAH55382.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAH55382.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAH67596.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAH67596.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ABG78033.1} RP NUCLEOTIDE SEQUENCE. RA Smith A.H., Chopra S.S., Roden D.M.; RT "Cloning gpd1h in adult zebrafish myocardium."; RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(+) = glycerone CC phosphate + NADH. {ECO:0000256|RuleBase:RU361243}. CC -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate CC dehydrogenase family. {ECO:0000256|RuleBase:RU000437}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055382; AAH55382.1; -; mRNA. DR EMBL; BC067596; AAH67596.1; -; mRNA. DR EMBL; DQ677583; ABG78033.1; -; mRNA. DR RefSeq; NP_956000.1; NM_199706.1. DR UniGene; Dr.79210; -. DR ProteinModelPortal; Q7T1E0; -. DR SMR; Q7T1E0; 1-350. DR STRING; 7955.ENSDARP00000063394; -. DR PRIDE; Q7T1E0; -. DR GeneID; 325181; -. DR KEGG; dre:325181; -. DR CTD; 325181; -. DR ZFIN; ZDB-GENE-030131-3906; gpd1b. DR eggNOG; COG0240; -. DR HOGENOM; HOG000246855; -. DR HOVERGEN; HBG003669; -. DR KO; K00006; -. DR PhylomeDB; Q7T1E0; -. DR Reactome; REACT_317406; Triglyceride Biosynthesis. DR Reactome; REACT_338865; Synthesis of PA. DR NextBio; 20809156; -. DR Bgee; Q7T1E0; -. DR ExpressionAtlas; Q7T1E0; differential. DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro. DR GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:UniProtKB-EC. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro. DR Gene3D; 1.10.1040.10; -; 1. DR Gene3D; 3.40.50.720; -; 1. DR InterPro; IPR008927; 6-PGluconate_DH_C-like. DR InterPro; IPR013328; DH_multihelical. DR InterPro; IPR006168; G3P_DH_NAD-dep. DR InterPro; IPR006109; G3P_DH_NAD-dep_C. DR InterPro; IPR017751; G3P_DH_NAD-dep_euk. DR InterPro; IPR011128; G3P_DH_NAD-dep_N. DR InterPro; IPR016040; NAD(P)-bd_dom. DR PANTHER; PTHR11728; PTHR11728; 1. DR Pfam; PF07479; NAD_Gly3P_dh_C; 1. DR Pfam; PF01210; NAD_Gly3P_dh_N; 1. DR PIRSF; PIRSF000114; Glycerol-3-P_dh; 1. DR PRINTS; PR00077; GPDHDRGNASE. DR SUPFAM; SSF48179; SSF48179; 1. DR TIGRFAMs; TIGR03376; glycerol3P_DH; 1. DR PROSITE; PS00957; NAD_G3PDH; 1. PE 2: Evidence at transcript level; KW NAD {ECO:0000256|RuleBase:RU000437}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000437}. FT REGION 270 271 Substrate binding. {ECO:0000256|PIRSR: FT PIRSR000114-2}. FT ACT_SITE 204 204 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000114-1}. FT BINDING 120 120 Substrate. {ECO:0000256|PIRSR: FT PIRSR000114-2}. SQ SEQUENCE 350 AA; 38194 MW; 6A124D0095BFFCD5 CRC64; MAAKKICIIG SGNWGSAIAK IVGANAAKYN TFENTVNMWV FEEMINGRKL TEIINTEHEN VKYLPGHKLP PNVLAVPDLL ESVKGADILI FVIPHQFVSR ICDTIKGHIK PDAVGMSLIK GVDEGPDGLK LISDVIREKL GITMTVLMGA NLANEVADEK FCETTIGCKS KPHGPLLKEL MQTQNFRVTV VEEADVVEIC GALKNIVAVG AGFCDGLSFG DNTKAAVIRL GLMEMIAFAR LFCTASPVSP ATFLESCGVA DLITTCYGGR NRKVGEAFAR TGKSIEELEK EMLNGQKLQG PATAAEVHQI LKHKNLVEKF PLFNAVYQIC FQNHPVKEFI MCLQNHPEHM //