ID Q7SZ53_DANRE Unreviewed; 222 AA. AC Q7SZ53; B2GRJ8; Q4V8X3; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 03-OCT-2006, sequence version 2. DT 27-MAR-2024, entry version 164. DE RecName: Full=Pentraxin family member {ECO:0000256|RuleBase:RU362112}; GN Name=crp2 {ECO:0000313|Ensembl:ENSDARP00000056380, GN ECO:0000313|RefSeq:NP_001020468.1, GN ECO:0000313|ZFIN:ZDB-GENE-030131-5826}; GN Synonyms=si:ch211-234p6.13 {ECO:0000313|EMBL:AAI65153.1, GN ECO:0000313|RefSeq:NP_001020468.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65153.1}; RN [1] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16630661; DOI=10.1016/j.molimm.2006.03.001; RA Lin B., Chen S., Cao Z., Lin Y., Mo D., Zhang H., Gu J., Dong M., Liu Z., RA Xu A.; RT "Acute phase response in zebrafish upon Aeromonas salmonicida and RT Staphylococcus aureus infection: striking similarities and obvious RT differences with mammals."; RL Mol. Immunol. 44:295-301(2007). RN [2] {ECO:0000313|EMBL:AAI65153.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=AB {ECO:0000313|EMBL:AAH54134.2}; RC TISSUE=Embryo {ECO:0000313|EMBL:AAH97160.1}, PCR rescue RC {ECO:0000313|EMBL:AAI65153.1}, and Whole body RC {ECO:0000313|EMBL:AAH54134.2}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22079493; DOI=10.1016/j.dci.2011.10.005; RA Falco A., Cartwright J.R., Wiegertjes G.F., Hoole D.; RT "Molecular characterization and expression analysis of two new C-reactive RT protein genes from common carp (Cyprinus carpio)."; RL Dev. Comp. Immunol. 37:127-138(2012). RN [4] {ECO:0000313|Ensembl:ENSDARP00000056380} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056380}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSDARP00000056380, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056380}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [6] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24683187; RA Briolat V., Jouneau L., Carvalho R., Palha N., Langevin C., Herbomel P., RA Schwartz O., Spaink H.P., Levraud J.P., Boudinot P.; RT "Contrasted innate responses to two viruses in zebrafish: insights into the RT ancestral repertoire of vertebrate IFN-stimulated genes."; RL J. Immunol. 192:4328-4341(2014). RN [7] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25592778; DOI=10.1016/j.jsb.2015.01.001; RA Chen R., Qi J., Yuan H., Wu Y., Hu W., Xia C.; RT "Crystal structures for short-chain pentraxin from zebrafish demonstrate a RT cyclic trimer with new recognition and effector faces."; RL J. Struct. Biol. 189:259-268(2015). RN [8] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25835394; RA Li F.J., Duggal R.N., Oliva O.M., Karki S., Surolia R., Wang Z., RA Watson R.D., Thannickal V.J., Powell M., Watts S., Kulkarni T., Batra H., RA Bolisetty S., Agarwal A., Antony V.B.; RT "Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial RT injury across species."; RL PLoS ONE 10:e0122275-e0122275(2015). RN [9] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28993314; RA van der Vaart M., Svoboda O., Weijts B.G., Espin-Palazon R., Sapp V., RA Pietri T., Bagnat M., Muotri A.R., Traver D.; RT "Mecp2 regulates tnfa during zebrafish embryonic development and acute RT inflammation."; RL Dis. Model. Mech. 10:1439-1451(2017). RN [10] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28915434; RA Bello-Perez M., Falco A., Medina-Gali R., Pereiro P., Encinar J.A., RA Novoa B., Perez L., Coll J.; RT "Neutralization of viral infectivity by zebrafish c-reactive protein RT isoforms."; RL Mol. Immunol. 91:145-155(2017). RN [11] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30170110; RA Medina-Gali R., Bello-Perez M., Martinez-Lopez A., Falco A., RA Ortega-Villaizan M.M., Encinar J.A., Novoa B., Coll J., Perez L.; RT "Chromatin immunoprecipitation and high throughput sequencing of SVCV- RT infected zebrafish reveals novel epigenetic histone methylation patterns RT involved in antiviral immune response."; RL Fish Shellfish Immunol. 82:514-521(2018). RN [12] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30547092; RA Van Gennip J.L.M., Boswell C.W., Ciruna B.; RT "Neuroinflammatory signals drive spinal curve formation in zebrafish models RT of idiopathic scoliosis."; RL Sci. Adv. 4:eaav1781-eaav1781(2018). RN [13] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30653529; RA Bello-Perez M., Falco A., Novoa B., Perez L., Coll J.; RT "Hydroxycholesterol binds and enhances the anti-viral activities of RT zebrafish monomeric c-reactive protein isoforms."; RL PLoS ONE 14:e0201509-e0201509(2019). RN [14] {ECO:0000313|RefSeq:NP_001020468.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|RuleBase:RU362112}; CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|RuleBase:RU362112}; CC -!- SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid CC arrangement of 5 non-covalently bound subunits. CC {ECO:0000256|RuleBase:RU362112}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362112}. CC -!- SIMILARITY: Belongs to the pentraxin family. CC {ECO:0000256|RuleBase:RU362112}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX001030; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC054134; AAH54134.2; -; mRNA. DR EMBL; BC097160; AAH97160.1; -; mRNA. DR EMBL; BC165153; AAI65153.1; -; mRNA. DR RefSeq; NP_001020468.1; NM_001025297.1. DR STRING; 7955.ENSDARP00000056380; -. DR PaxDb; 7955-ENSDARP00000056380; -. DR Ensembl; ENSDART00000056381.5; ENSDARP00000056380.4; ENSDARG00000056462.7. DR GeneID; 327615; -. DR KEGG; dre:327615; -. DR AGR; ZFIN:ZDB-GENE-030131-5826; -. DR CTD; 327615; -. DR ZFIN; ZDB-GENE-030131-5826; crp2. DR eggNOG; ENOG502S201; Eukaryota. DR HOGENOM; CLU_032051_2_0_1; -. DR OMA; CMKLATE; -. DR OrthoDB; 4219275at2759; -. DR ChiTaRS; crp2; zebrafish. DR Proteomes; UP000000437; Chromosome 24. DR Bgee; ENSDARG00000056462; Expressed in tail and 21 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0015485; F:cholesterol binding; IDA:ZFIN. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0051607; P:defense response to virus; IDA:ZFIN. DR GO; GO:0009617; P:response to bacterium; IDA:ZFIN. DR CDD; cd00152; PTX; 1. DR Gene3D; 2.60.120.200; -; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR030476; Pentaxin_CS. DR InterPro; IPR001759; Pentraxin-related. DR PANTHER; PTHR45869; C-REACTIVE PROTEIN-RELATED; 1. DR PANTHER; PTHR45869:SF2; PENTAXIN; 1. DR Pfam; PF00354; Pentaxin; 1. DR PRINTS; PR00895; PENTAXIN. DR SMART; SM00159; PTX; 1. DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1. DR PROSITE; PS00289; PTX_1; 1. DR PROSITE; PS51828; PTX_2; 1. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|RuleBase:RU362112}; KW Metal-binding {ECO:0000256|RuleBase:RU362112}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7SZ53}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..15 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 16..222 FT /note="Pentraxin family member" FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001020468.1" FT /id="PRO_5035034332" SQ SEQUENCE 222 AA; 24947 MW; 5A68FC82757A8ECC CRC64; MLLFFCLLSV TLAAAEVGLS GKTLLFPTAT DTSYVKLSPR KPLSLSAFTL CMRVATELPA KREIILFAYR TPDDDELNVW REKDGRFSVY IQSSKDAAFF RLHPLSTFQT HLCVTWESAT GLTAFWVDGQ RSLHQVYRKG YSIRPGGTVL LGQDPDSYVG SFNAAQSFVG EITDLQMWDY VLSGTQIKAV YYNQDNRVKG NVFDWNTIKY DVTGNVLVVP DN //