ID Q7SZ53_DANRE Unreviewed; 222 AA. AC Q7SZ53; Q4V8X3; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 03-OCT-2006, sequence version 2. DT 12-OCT-2022, entry version 156. DE RecName: Full=Pentaxin {ECO:0000256|RuleBase:RU362112}; DE AltName: Full=Pentraxin {ECO:0000256|RuleBase:RU362112}; GN Name=si:ch211-234p6.13 {ECO:0000313|EMBL:AAI65153.1, GN ECO:0000313|RefSeq:NP_001020468.1}; GN Synonyms=wu:fi20c07 {ECO:0000313|RefSeq:NP_001020468.1}; GN OrderedLocusNames=crp2 {ECO:0000313|RefSeq:NP_001020468.1, GN ECO:0000313|ZFIN:ZDB-GENE-030131-5826}; GN ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-030131-5826}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI65153.1}; RN [1] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16630661; DOI=10.1016/j.molimm.2006.03.001; RA Lin B., Chen S., Cao Z., Lin Y., Mo D., Zhang H., Gu J., Dong M., Liu Z., RA Xu A.; RT "Acute phase response in zebrafish upon Aeromonas salmonicida and RT Staphylococcus aureus infection: striking similarities and obvious RT differences with mammals."; RL Mol. Immunol. 44:295-301(2007). RN [2] {ECO:0000313|EMBL:AAI65153.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAH97160.1}, and PCR rescue RC {ECO:0000313|EMBL:AAI65153.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=22079493; DOI=10.1016/j.dci.2011.10.005; RA Falco A., Cartwright J.R., Wiegertjes G.F., Hoole D.; RT "Molecular characterization and expression analysis of two new C-reactive RT protein genes from common carp (Cyprinus carpio)."; RL Dev. Comp. Immunol. 37:127-138(2012). RN [4] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=24683187; RA Briolat V., Jouneau L., Carvalho R., Palha N., Langevin C., Herbomel P., RA Schwartz O., Spaink H.P., Levraud J.P., Boudinot P.; RT "Contrasted innate responses to two viruses in zebrafish: insights into the RT ancestral repertoire of vertebrate IFN-stimulated genes."; RL J. Immunol. 192:4328-4341(2014). RN [5] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25592778; DOI=10.1016/j.jsb.2015.01.001; RA Chen R., Qi J., Yuan H., Wu Y., Hu W., Xia C.; RT "Crystal structures for short-chain pentraxin from zebrafish demonstrate a RT cyclic trimer with new recognition and effector faces."; RL J. Struct. Biol. 189:259-268(2015). RN [6] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25835394; RA Li F.J., Duggal R.N., Oliva O.M., Karki S., Surolia R., Wang Z., RA Watson R.D., Thannickal V.J., Powell M., Watts S., Kulkarni T., Batra H., RA Bolisetty S., Agarwal A., Antony V.B.; RT "Heme oxygenase-1 protects corexit 9500A-induced respiratory epithelial RT injury across species."; RL PLoS ONE 10:e0122275-e0122275(2015). RN [7] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28993314; RA van der Vaart M., Svoboda O., Weijts B.G., Espin-Palazon R., Sapp V., RA Pietri T., Bagnat M., Muotri A.R., Traver D.; RT "Mecp2 regulates tnfa during zebrafish embryonic development and acute RT inflammation."; RL Dis. Model. Mech. 10:1439-1451(2017). RN [8] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28915434; RA Bello-Perez M., Falco A., Medina-Gali R., Pereiro P., Encinar J.A., RA Novoa B., Perez L., Coll J.; RT "Neutralization of viral infectivity by zebrafish c-reactive protein RT isoforms."; RL Mol. Immunol. 91:145-155(2017). RN [9] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30170110; RA Medina-Gali R., Bello-Perez M., Martinez-Lopez A., Falco A., RA Ortega-Villaizan M.M., Encinar J.A., Novoa B., Coll J., Perez L.; RT "Chromatin immunoprecipitation and high throughput sequencing of SVCV- RT infected zebrafish reveals novel epigenetic histone methylation patterns RT involved in antiviral immune response."; RL Fish Shellfish Immunol. 82:514-521(2018). RN [10] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30547092; RA Van Gennip J.L.M., Boswell C.W., Ciruna B.; RT "Neuroinflammatory signals drive spinal curve formation in zebrafish models RT of idiopathic scoliosis."; RL Sci. Adv. 4:eaav1781-eaav1781(2018). RN [11] {ECO:0000313|RefSeq:NP_001020468.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30653529; RA Bello-Perez M., Falco A., Novoa B., Perez L., Coll J.; RT "Hydroxycholesterol binds and enhances the anti-viral activities of RT zebrafish monomeric c-reactive protein isoforms."; RL PLoS ONE 14:e0201509-e0201509(2019). RN [12] {ECO:0000313|RefSeq:NP_001020468.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (APR-2022) to UniProtKB. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|RuleBase:RU362112}; CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|RuleBase:RU362112}; CC -!- SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid CC arrangement of 5 non-covalently bound subunits. CC {ECO:0000256|RuleBase:RU362112}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362112}. CC -!- SIMILARITY: Belongs to the pentraxin family. CC {ECO:0000256|RuleBase:RU362112}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC097160; AAH97160.1; -; mRNA. DR EMBL; BC165153; AAI65153.1; -; mRNA. DR RefSeq; NP_001020468.1; NM_001025297.1. DR STRING; 7955.ENSDARP00000056380; -. DR GeneID; 327615; -. DR KEGG; dre:327615; -. DR CTD; 327615; -. DR ZFIN; ZDB-GENE-030131-5826; crp2. DR ZFIN; ZDB-GENE-030131-5826; SO:0001217. DR eggNOG; ENOG502S201; Eukaryota. DR HOGENOM; CLU_032051_2_0_1; -. DR OMA; NIFDWKS; -. DR ChiTaRS; crp2; zebrafish. DR Proteomes; UP000000437; Chromosome 24. DR Bgee; ENSDARG00000056462; Expressed in tail and 21 other tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0015485; F:cholesterol binding; IDA:ZFIN. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0009617; P:response to bacterium; IDA:ZFIN. DR CDD; cd00152; PTX; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR030476; Pentaxin_CS. DR InterPro; IPR001759; Pentraxin-related. DR Pfam; PF00354; Pentaxin; 1. DR PRINTS; PR00895; PENTAXIN. DR SMART; SM00159; PTX; 1. DR SUPFAM; SSF49899; SSF49899; 1. DR PROSITE; PS00289; PTX_1; 1. DR PROSITE; PS51828; PTX_2; 1. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|RuleBase:RU362112}; KW Metal-binding {ECO:0000256|RuleBase:RU362112}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001020468.1}. FT SIGNAL 1..15 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 16..222 FT /note="Pentaxin" FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001020468.1" FT /id="PRO_5035034332" SQ SEQUENCE 222 AA; 24947 MW; 5A68FC82757A8ECC CRC64; MLLFFCLLSV TLAAAEVGLS GKTLLFPTAT DTSYVKLSPR KPLSLSAFTL CMRVATELPA KREIILFAYR TPDDDELNVW REKDGRFSVY IQSSKDAAFF RLHPLSTFQT HLCVTWESAT GLTAFWVDGQ RSLHQVYRKG YSIRPGGTVL LGQDPDSYVG SFNAAQSFVG EITDLQMWDY VLSGTQIKAV YYNQDNRVKG NVFDWNTIKY DVTGNVLVVP DN //