ID Q7SZ53_DANRE Unreviewed; 222 AA. AC Q7SZ53; Q4V8X3; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 03-OCT-2006, sequence version 2. DT 16-JAN-2019, entry version 134. DE RecName: Full=Pentaxin {ECO:0000256|RuleBase:RU362112}; DE AltName: Full=Pentraxin {ECO:0000256|RuleBase:RU362112}; GN Name=crp2 {ECO:0000313|Ensembl:ENSDARP00000056380, GN ECO:0000313|ZFIN:ZDB-GENE-030131-5826}; GN Synonyms=si:ch211-234p6.13 {ECO:0000313|EMBL:AAH54134.2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH54134.2}; RN [1] {ECO:0000313|EMBL:AAH54134.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=AB {ECO:0000313|EMBL:AAH54134.2}; RC TISSUE=Whole body {ECO:0000313|EMBL:AAH54134.2}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAH97160.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo {ECO:0000313|EMBL:AAH97160.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:AAI65153.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65153.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSDARP00000056380} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056380}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [5] {ECO:0000313|Ensembl:ENSDARP00000056380, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056380, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|RuleBase:RU362112}; CC Note=Binds 2 calcium ions per subunit. CC {ECO:0000256|RuleBase:RU362112}; CC -!- SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid CC arrangement of 5 non-covalently bound subunits. CC {ECO:0000256|RuleBase:RU362112}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362112}. CC -!- SIMILARITY: Belongs to the pentraxin family. CC {ECO:0000256|RuleBase:RU362112}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX001030; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC054134; AAH54134.2; -; mRNA. DR EMBL; BC097160; AAH97160.1; -; mRNA. DR EMBL; BC165153; AAI65153.1; -; mRNA. DR RefSeq; NP_001020468.1; NM_001025297.1. DR UniGene; Dr.85543; -. DR Ensembl; ENSDART00000056381; ENSDARP00000056380; ENSDARG00000056462. DR GeneID; 327615; -. DR KEGG; dre:327615; -. DR CTD; 327615; -. DR ZFIN; ZDB-GENE-030131-5826; crp2. DR eggNOG; ENOG410J1FD; Eukaryota. DR eggNOG; ENOG410YN8S; LUCA. DR GeneTree; ENSGT00940000154867; -. DR HOVERGEN; HBG005405; -. DR OMA; WNGERHA; -. DR OrthoDB; 809942at2759; -. DR ChiTaRS; crp2; zebrafish. DR Proteomes; UP000000437; Chromosome 24. DR Bgee; ENSDARG00000056462; Expressed in 18 organ(s), highest expression level in female gonad. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0009617; P:response to bacterium; IDA:ZFIN. DR CDD; cd00152; PTX; 1. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR030476; Pentaxin_CS. DR InterPro; IPR001759; Pentraxin-related. DR Pfam; PF00354; Pentaxin; 1. DR PRINTS; PR00895; PENTAXIN. DR SMART; SM00159; PTX; 1. DR SUPFAM; SSF49899; SSF49899; 1. DR PROSITE; PS00289; PTX_1; 1. DR PROSITE; PS51828; PTX_2; 1. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|RuleBase:RU362112}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Metal-binding {ECO:0000256|RuleBase:RU362112}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q7SZ53}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 222 Pentaxin. {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015098842. SQ SEQUENCE 222 AA; 24947 MW; 5A68FC82757A8ECC CRC64; MLLFFCLLSV TLAAAEVGLS GKTLLFPTAT DTSYVKLSPR KPLSLSAFTL CMRVATELPA KREIILFAYR TPDDDELNVW REKDGRFSVY IQSSKDAAFF RLHPLSTFQT HLCVTWESAT GLTAFWVDGQ RSLHQVYRKG YSIRPGGTVL LGQDPDSYVG SFNAAQSFVG EITDLQMWDY VLSGTQIKAV YYNQDNRVKG NVFDWNTIKY DVTGNVLVVP DN //