ID DC2L1_DANRE Reviewed; 358 AA. AC Q7SXY4; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 08-NOV-2023, entry version 97. DE RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1; GN Name=dync2li1; ORFNames=zgc:63673; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=SJD; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of CC the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein CC complex that drives the movement of cargos along microtubules within CC cilia and flagella in concert with the intraflagellar transport (IFT) CC system, facilitating the assembly of these organelles. CC {ECO:0000250|UniProtKB:Q8TCX1}. CC -!- SUBUNIT: Light intermediate chain of the cytoplasmic dynein complex 2, CC a multisubunit complex composed at least of eleven different proteins. CC The cytoplasmic dynein 2 complex consists of two catalytic heavy chains CC (HCs) and a number of non-catalytic subunits presented by intermediate CC chains (ICs), light intermediate chains (LICs) and light chains (LCs). CC Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 CC and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain CC (DYNLT2B) are unique to the dynein-2 complex, but a subset of light CC chains are also shared by dynein-1 and dynein-2 complexes. Dynein-2 CC complex is built around two copies of cytoplasmic dynein 2 heavy chain CC 1 (DYNC2H1). The C-terminal region forms the motor domain, which CC converts the energy from ATP hydrolysis into movement. Its N-terminal CC region forms the tail, an extended structure that binds the other CC subunits and holds the two heavy chains in a homodimer. CC {ECO:0000250|UniProtKB:Q8TCX1}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. Cell CC projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}. CC Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K0T2}. CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome CC {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical cytoplasm. CC {ECO:0000250|UniProtKB:Q8K0T2}. CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055198; AAH55198.1; -; mRNA. DR RefSeq; NP_956774.1; NM_200480.1. DR AlphaFoldDB; Q7SXY4; -. DR SMR; Q7SXY4; -. DR STRING; 7955.ENSDARP00000058146; -. DR PaxDb; 7955-ENSDARP00000058146; -. DR GeneID; 393452; -. DR KEGG; dre:393452; -. DR CTD; 51626; -. DR ZFIN; ZDB-GENE-040426-1230; dync2li1. DR eggNOG; KOG3929; Eukaryota. DR InParanoid; Q7SXY4; -. DR OrthoDB; 313424at2759; -. DR PhylomeDB; Q7SXY4; -. DR Reactome; R-DRE-5620924; Intraflagellar transport. DR PRO; PR:Q7SXY4; -. DR Proteomes; UP000000437; Alternate scaffold 13. DR Proteomes; UP000000437; Chromosome 13. DR GO; GO:0005930; C:axoneme; IBA:GO_Central. DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central. DR GO; GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0097730; C:non-motile cilium; IMP:ZFIN. DR GO; GO:0045504; F:dynein heavy chain binding; ISS:UniProtKB. DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central. DR GO; GO:0042073; P:intraciliary transport; IMP:ZFIN. DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR040045; DYNC2LI1. DR InterPro; IPR022780; Dynein_light_int_chain. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR13236:SF0; CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1; 1. DR PANTHER; PTHR13236; DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2; 1. DR Pfam; PF05783; DLIC; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm; KW Cytoskeleton; Developmental protein; Dynein; Microtubule; Motor protein; KW Reference proteome. FT CHAIN 1..358 FT /note="Cytoplasmic dynein 2 light intermediate chain 1" FT /id="PRO_0000318753" FT REGION 1..35 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 307..358 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 307..323 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 332..352 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 358 AA; 40189 MW; 01769370C1B7F5AD CRC64; MPKVSSDTLW DIAAAEVRSR ESRTDEEEAE EEDAHFPSQR TVFFMGSKAG GKTTILLRFL ERDETAKPTL ALEYTFGRRA RGHNTPKDIA HLWELGGGIS LSDLVQIPIT ADNVSFLSVV LVLDLSKPNA LWETMESLLG SARNQVEKVC AALQKTGESR SGKQRVPRVL HKDYPDRELI SPFPVPLLIV GSKFDIFQDF DSEKRKVICK TLRFLAHFYG ASLIFTSSKS ETTMSKSRSF INQLAFGTER PKSISTDPSK PLAIPAGSDS LSQIGPPVAT EVDIGTLHAK NPFDLWKKVF EKVFPHESTR ERKELKDPVK DPQFSEPLID SIRAQKDQEL DQYKREQAKS WKSLALDP //