ID DC2L1_DANRE Reviewed; 358 AA. AC Q7SXY4; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 07-OCT-2020, entry version 86. DE RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1; GN Name=dync2li1; ORFNames=zgc:63673; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=SJD; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for correct intraflagellar transport (IFT), the bi- CC directional movement of particles required for the assembly, CC maintenance and functioning of primary cilia. Involved in the CC regulation of ciliary length. {ECO:0000250|UniProtKB:Q8TCX1}. CC -!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by a CC heavy chain homodimer and a number of DYNC2LI1 light intermediate CC chains. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. Cell CC projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}. CC Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K0T2}. CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome CC {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical cytoplasm. CC {ECO:0000250|UniProtKB:Q8K0T2}. CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055198; AAH55198.1; -; mRNA. DR RefSeq; NP_956774.1; NM_200480.1. DR SMR; Q7SXY4; -. DR STRING; 7955.ENSDARP00000058146; -. DR PaxDb; Q7SXY4; -. DR GeneID; 393452; -. DR KEGG; dre:393452; -. DR CTD; 51626; -. DR ZFIN; ZDB-GENE-040426-1230; dync2li1. DR eggNOG; KOG3929; Eukaryota. DR InParanoid; Q7SXY4; -. DR KO; K10417; -. DR OrthoDB; 910690at2759; -. DR PhylomeDB; Q7SXY4; -. DR Reactome; R-DRE-5620924; Intraflagellar transport. DR PRO; PR:Q7SXY4; -. DR Proteomes; UP000000437; Unplaced. DR GO; GO:0005930; C:axoneme; IBA:GO_Central. DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central. DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0097730; C:non-motile cilium; IMP:ZFIN. DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central. DR GO; GO:0003774; F:motor activity; IEA:UniProtKB-KW. DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central. DR GO; GO:0042073; P:intraciliary transport; IMP:ZFIN. DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR InterPro; IPR040045; DYNC2LI1. DR InterPro; IPR022780; Dynein_light_int_chain. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR13236; PTHR13236; 1. DR Pfam; PF05783; DLIC; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm; KW Cytoskeleton; Developmental protein; Dynein; Microtubule; Motor protein; KW Reference proteome. FT CHAIN 1..358 FT /note="Cytoplasmic dynein 2 light intermediate chain 1" FT /id="PRO_0000318753" SQ SEQUENCE 358 AA; 40189 MW; 01769370C1B7F5AD CRC64; MPKVSSDTLW DIAAAEVRSR ESRTDEEEAE EEDAHFPSQR TVFFMGSKAG GKTTILLRFL ERDETAKPTL ALEYTFGRRA RGHNTPKDIA HLWELGGGIS LSDLVQIPIT ADNVSFLSVV LVLDLSKPNA LWETMESLLG SARNQVEKVC AALQKTGESR SGKQRVPRVL HKDYPDRELI SPFPVPLLIV GSKFDIFQDF DSEKRKVICK TLRFLAHFYG ASLIFTSSKS ETTMSKSRSF INQLAFGTER PKSISTDPSK PLAIPAGSDS LSQIGPPVAT EVDIGTLHAK NPFDLWKKVF EKVFPHESTR ERKELKDPVK DPQFSEPLID SIRAQKDQEL DQYKREQAKS WKSLALDP //