ID DC2L1_DANRE Reviewed; 358 AA. AC Q7SXY4; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 13-NOV-2019, entry version 82. DE RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1; GN Name=dync2li1; ORFNames=zgc:63673; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=SJD; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Required for correct intraflagellar transport (IFT), the CC bi-directional movement of particles required for the assembly, CC maintenance and functioning of primary cilia. Involved in the CC regulation of ciliary length. {ECO:0000250|UniProtKB:Q8TCX1}. CC -!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by CC a heavy chain homodimer and a number of DYNC2LI1 light CC intermediate chains. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. CC Cell projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, CC cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}. CC Cytoplasm, cytoskeleton, cilium axoneme CC {ECO:0000250|UniProtKB:Q8K0T2}. Cytoplasm, cytoskeleton, CC microtubule organizing center, centrosome CC {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical CC cytoplasm. {ECO:0000250|UniProtKB:Q8K0T2}. CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055198; AAH55198.1; -; mRNA. DR RefSeq; NP_956774.1; NM_200480.1. DR STRING; 7955.ENSDARP00000058146; -. DR PaxDb; Q7SXY4; -. DR GeneID; 393452; -. DR KEGG; dre:393452; -. DR CTD; 51626; -. DR ZFIN; ZDB-GENE-040426-1230; dync2li1. DR eggNOG; KOG3929; Eukaryota. DR eggNOG; ENOG410XTE5; LUCA. DR HOGENOM; HOG000006828; -. DR InParanoid; Q7SXY4; -. DR KO; K10417; -. DR OrthoDB; 910690at2759; -. DR PhylomeDB; Q7SXY4; -. DR Reactome; R-DRE-5620924; Intraflagellar transport. DR PRO; PR:Q7SXY4; -. DR Proteomes; UP000000437; Unplaced. DR GO; GO:0005930; C:axoneme; IBA:GO_Central. DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central. DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0097730; C:non-motile cilium; IMP:ZFIN. DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central. DR GO; GO:0003774; F:motor activity; IEA:UniProtKB-KW. DR GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central. DR GO; GO:0042073; P:intraciliary transport; IMP:ZFIN. DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IBA:GO_Central. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR InterPro; IPR040045; DYNC2LI1. DR InterPro; IPR022780; Dynein_light_int_chain. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR13236; PTHR13236; 1. DR Pfam; PF05783; DLIC; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Cilium biogenesis/degradation; KW Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; KW Dynein; Microtubule; Motor protein; Reference proteome. FT CHAIN 1 358 Cytoplasmic dynein 2 light intermediate FT chain 1. FT /FTId=PRO_0000318753. SQ SEQUENCE 358 AA; 40189 MW; 01769370C1B7F5AD CRC64; MPKVSSDTLW DIAAAEVRSR ESRTDEEEAE EEDAHFPSQR TVFFMGSKAG GKTTILLRFL ERDETAKPTL ALEYTFGRRA RGHNTPKDIA HLWELGGGIS LSDLVQIPIT ADNVSFLSVV LVLDLSKPNA LWETMESLLG SARNQVEKVC AALQKTGESR SGKQRVPRVL HKDYPDRELI SPFPVPLLIV GSKFDIFQDF DSEKRKVICK TLRFLAHFYG ASLIFTSSKS ETTMSKSRSF INQLAFGTER PKSISTDPSK PLAIPAGSDS LSQIGPPVAT EVDIGTLHAK NPFDLWKKVF EKVFPHESTR ERKELKDPVK DPQFSEPLID SIRAQKDQEL DQYKREQAKS WKSLALDP //