ID DC2L1_DANRE Reviewed; 358 AA. AC Q7SXY4; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 08-JUN-2016, entry version 70. DE RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1; GN Name=dync2li1; ORFNames=zgc:63673; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=SJD; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May function as a motor for intraflagellar retrograde CC transport. Functions in cilia biogenesis (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: The cytoplasmic dynein complex 2 is probably composed by CC a heavy chain homodimer and a number of DYNC2LI1 light CC intermediate chains. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme CC {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localizes to the CC apical cytoplasm. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055198; AAH55198.1; -; mRNA. DR RefSeq; NP_956774.1; NM_200480.1. DR UniGene; Dr.117470; -. DR ProteinModelPortal; Q7SXY4; -. DR STRING; 7955.ENSDARP00000058146; -. DR PaxDb; Q7SXY4; -. DR GeneID; 393452; -. DR KEGG; dre:393452; -. DR CTD; 51626; -. DR ZFIN; ZDB-GENE-040426-1230; dync2li1. DR eggNOG; KOG3929; Eukaryota. DR eggNOG; ENOG410XTE5; LUCA. DR HOGENOM; HOG000006828; -. DR HOVERGEN; HBG066237; -. DR InParanoid; Q7SXY4; -. DR KO; K10417; -. DR PhylomeDB; Q7SXY4; -. DR PRO; PR:Q7SXY4; -. DR Proteomes; UP000000437; Unplaced. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0031513; C:nonmotile primary cilium; IMP:ZFIN. DR GO; GO:0003774; F:motor activity; IEA:UniProtKB-KW. DR GO; GO:0042073; P:intraciliary transport; IMP:ZFIN. DR GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.300; -; 2. DR InterPro; IPR022780; Dynein_light_int_chain. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF05783; DLIC; 1. DR SUPFAM; SSF52540; SSF52540; 2. PE 2: Evidence at transcript level; KW Cell projection; Cilium; Cilium biogenesis/degradation; KW Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; KW Dynein; Microtubule; Motor protein; Reference proteome. FT CHAIN 1 358 Cytoplasmic dynein 2 light intermediate FT chain 1. FT /FTId=PRO_0000318753. SQ SEQUENCE 358 AA; 40189 MW; 01769370C1B7F5AD CRC64; MPKVSSDTLW DIAAAEVRSR ESRTDEEEAE EEDAHFPSQR TVFFMGSKAG GKTTILLRFL ERDETAKPTL ALEYTFGRRA RGHNTPKDIA HLWELGGGIS LSDLVQIPIT ADNVSFLSVV LVLDLSKPNA LWETMESLLG SARNQVEKVC AALQKTGESR SGKQRVPRVL HKDYPDRELI SPFPVPLLIV GSKFDIFQDF DSEKRKVICK TLRFLAHFYG ASLIFTSSKS ETTMSKSRSF INQLAFGTER PKSISTDPSK PLAIPAGSDS LSQIGPPVAT EVDIGTLHAK NPFDLWKKVF EKVFPHESTR ERKELKDPVK DPQFSEPLID SIRAQKDQEL DQYKREQAKS WKSLALDP //