ID Q7SXW7_DANRE Unreviewed; 561 AA. AC Q7SXW7; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 03-MAY-2023, entry version 111. DE SubName: Full=Phosphoglucomutase-1 {ECO:0000313|EMBL:AAH55219.1, ECO:0000313|RefSeq:NP_957319.1}; DE EC=5.4.2.2 {ECO:0000313|RefSeq:NP_957319.1}; GN Name=zgc:63718 {ECO:0000313|RefSeq:NP_957319.1}; GN OrderedLocusNames=pgm1 {ECO:0000313|EMBL:AAH55219.1, GN ECO:0000313|RefSeq:NP_957319.1, GN ECO:0000313|ZFIN:ZDB-GENE-040426-1245}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH55219.1}; RN [1] {ECO:0000313|EMBL:AAH55219.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=AB {ECO:0000313|EMBL:AAH55219.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:AAH55219.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=18307296; DOI=10.1021/pr700667w; RA Lemeer S., Pinkse M.W., Mohammed S., van Breukelen B., den Hertog J., RA Slijper M., Heck A.J.; RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale RT analysis down to a single embryo."; RL J. Proteome Res. 7:1555-1564(2008). RN [3] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=20528263; RA Singh S.K., Sundaram C.S., Shanbhag S., Idris M.M.; RT "Proteomic profile of zebrafish brain based on two-dimensional gel RT electrophoresis matrix-assisted laser desorption/ionization MS/MS RT analysis."; RL Zebrafish 7:169-177(2010). RN [4] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=21075138; RA Xiong X.P., Dong C.F., Xu X., Weng S.P., Liu Z.Y., He J.G.; RT "Proteomic analysis of zebrafish (Danio rerio) infected with infectious RT spleen and kidney necrosis virus."; RL Dev. Comp. Immunol. 35:431-440(2011). RN [5] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=24476500; RA Motorykin I., Traber M.G., Tanguay R.L., Maier C.S.; RT "Proteome-driven elucidation of adaptive responses to combined vitamin E RT and C deficiency in zebrafish."; RL J. Proteome Res. 13:1647-1656(2014). RN [6] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=26046835; RA Carneiro M., Gutierrez-Praena D., Osorio H., Vasconcelos V., Carvalho A.P., RA Campos A.; RT "Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals RT gender specific responses and additional mechanisms of cell stress."; RL Ecotoxicol. Environ. Saf. 120:93-101(2015). RN [7] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=25931610; RA Abascal F., Tress M.L., Valencia A.; RT "The evolutionary fate of alternatively spliced homologous exons after gene RT duplication."; RL Genome Biol. Evol. 7:1392-1403(2015). RN [8] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [9] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=27189481; RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I., RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y., RA Bobe J.; RT "Gene evolution and gene expression after whole genome duplication in fish: RT the PhyloFish database."; RL BMC Genomics 17:368-368(2016). RN [10] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [11] {ECO:0000313|RefSeq:NP_957319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RX PubMed=29145436; RA Yilmaz O., Patinote A., Nguyen T.V., Com E., Lavigne R., Pineau C., RA Sullivan C.V., Bobe J.; RT "Scrambled eggs: Proteomic portraits and novel biomarkers of egg quality in RT zebrafish (Danio rerio)."; RL PLoS ONE 12:e0188084-e0188084(2017). RN [12] {ECO:0000313|RefSeq:NP_957319.1} RP IDENTIFICATION. RC STRAIN=AB {ECO:0000313|RefSeq:NP_957319.1}; RG RefSeq; RL Submitted (JAN-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the phosphohexose mutase family. CC {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|RuleBase:RU004326}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC055219; AAH55219.1; -; mRNA. DR RefSeq; NP_957319.1; NM_201025.1. DR GeneID; 394000; -. DR KEGG; dre:394000; -. DR CTD; 5236; -. DR ZFIN; ZDB-GENE-040426-1245; pgm1. DR OrthoDB; 5476118at2759; -. DR PhylomeDB; Q7SXW7; -. DR Proteomes; UP000000437; Chromosome 6. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro. DR GO; GO:0004614; F:phosphoglucomutase activity; IBA:GO_Central. DR GO; GO:0005975; P:carbohydrate metabolic process; IBA:GO_Central. DR CDD; cd03085; PGM1; 1. DR Gene3D; 3.40.120.10; Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3; 3. DR Gene3D; 3.30.310.50; Alpha-D-phosphohexomutase, C-terminal domain; 1. DR InterPro; IPR005844; A-D-PHexomutase_a/b/a-I. DR InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III. DR InterPro; IPR005845; A-D-PHexomutase_a/b/a-II. DR InterPro; IPR005846; A-D-PHexomutase_a/b/a-III. DR InterPro; IPR036900; A-D-PHexomutase_C_sf. DR InterPro; IPR016066; A-D-PHexomutase_CS. DR InterPro; IPR005841; Alpha-D-phosphohexomutase_SF. DR InterPro; IPR045244; PGM. DR PANTHER; PTHR22573:SF37; PHOSPHOGLUCOMUTASE-1; 1. DR PANTHER; PTHR22573; PHOSPHOHEXOMUTASE FAMILY MEMBER; 1. DR Pfam; PF02878; PGM_PMM_I; 1. DR Pfam; PF02879; PGM_PMM_II; 1. DR Pfam; PF02880; PGM_PMM_III; 1. DR PRINTS; PR00509; PGMPMM. DR SUPFAM; SSF55957; Phosphoglucomutase, C-terminal domain; 1. DR SUPFAM; SSF53738; Phosphoglucomutase, first 3 domains; 3. DR PROSITE; PS00710; PGM_PMM; 1. PE 1: Evidence at protein level; KW Magnesium {ECO:0000256|RuleBase:RU004326}; KW Metal-binding {ECO:0000256|RuleBase:RU004326}; KW Proteomics identification {ECO:0007829|PeptideAtlas:Q7SXW7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 15..157 FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha" FT /evidence="ECO:0000259|Pfam:PF02878" FT DOMAIN 193..298 FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha" FT /evidence="ECO:0000259|Pfam:PF02879" FT DOMAIN 306..419 FT /note="Alpha-D-phosphohexomutase alpha/beta/alpha" FT /evidence="ECO:0000259|Pfam:PF02880" SQ SEQUENCE 561 AA; 61129 MW; 8090A53590C9DC34 CRC64; MVKITVIKTK PYTDQKPGTS GLRKRVTVFQ QNQHYAENFI QSIISTVDPA QRQEGALVVG GDGRFFMKDA IQLIIQIAAA NGIGRLVIGQ DGIMSTPAVS CVIRKIKAIG GIILTASHNP GGPNGDFGIK FNISSGGPAP EGITDKIFQI SKSLQEYHIC PELKVDLSTI GKQTFEVDTF KPFTVEIVDS VESYAEMLRD IFDFAALKEL LSGPNHINVR LDAMHGVVGP YVKKIVCEEL GSPANSAVNC VPSEDFGGHH PDPNLTYAAD LVNTMKGGEY DFGAAFDGDG DRNMVLGKHG SFVNPSDSVA VIGANITSIP YFQKTGVKGL ARSMPTSGAL DNVAKALKMP LYETPTGWKF FGNLMDAGKL SLCGEESFGT GSDHIREKDG LWAVLAWLSI LATRKQSVED IMKDHWQKFG RNFFTRYDYE EVDSDAANKM IDHLQTTMFD KAFVGQTFTS GDKTYQVEKA DNFEYTDPVD GSVSKGQGLR IIFSDGSRII FRLSGTGSAG ATIRLYIDSY EKDPQKIYQD PQVMLAPLVD IALKISQLQE KTGRAAPTVI T //