ID EMC3_DANRE Reviewed; 261 AA. AC Q7SXW4; Q5IFI3; DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 16-OCT-2019, entry version 94. DE RecName: Full=ER membrane protein complex subunit 3; DE AltName: Full=Protein pob; DE AltName: Full=Transmembrane protein 111; GN Name=emc3; Synonyms=pob, tmem111; ORFNames=zgc:63727; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RX PubMed=15716502; DOI=10.1534/genetics.104.036434; RA Taylor M.R., Kikkawa S., Diez-Juan A., Ramamurthy V., Kawakami K., RA Carmeliet P., Brockerhoff S.E.; RT "The zebrafish pob gene encodes a novel protein required for survival RT of red cone photoreceptor cells."; RL Genetics 170:263-273(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney marrow; RX PubMed=15520368; DOI=10.1073/pnas.0407241101; RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., RA Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., RA Kanki J.P., Liu T.X., Look A.T., Chen Z.; RT "Hematopoietic gene expression profile in zebrafish kidney marrow."; RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=AB; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane CC protein {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Localized to the inner segment and synapse in CC photoreceptor cells. {ECO:0000269|PubMed:15716502}. CC -!- SIMILARITY: Belongs to the EMC3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY745978; AAW19648.1; -; mRNA. DR EMBL; AY398377; AAQ97810.1; -; mRNA. DR EMBL; BC055222; AAH55222.1; -; mRNA. DR RefSeq; NP_998670.1; NM_213505.2. DR SMR; Q7SXW4; -. DR STRING; 7955.ENSDARP00000106382; -. DR PaxDb; Q7SXW4; -. DR Ensembl; ENSDART00000129302; ENSDARP00000106382; ENSDARG00000020607. DR GeneID; 406826; -. DR KEGG; dre:406826; -. DR CTD; 55831; -. DR ZFIN; ZDB-GENE-040426-2904; emc3. DR eggNOG; KOG3188; Eukaryota. DR eggNOG; ENOG410XQK6; LUCA. DR GeneTree; ENSGT00390000005780; -. DR HOGENOM; HOG000158234; -. DR InParanoid; Q7SXW4; -. DR KO; K23564; -. DR OMA; PNIRGWV; -. DR OrthoDB; 1482782at2759; -. DR PhylomeDB; Q7SXW4; -. DR PRO; PR:Q7SXW4; -. DR Proteomes; UP000000437; Chromosome 6. DR Bgee; ENSDARG00000020607; Expressed in 30 organ(s), highest expression level in eye. DR GO; GO:0072546; C:ER membrane protein complex; ISS:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; IDA:ZFIN. DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB. DR GO; GO:0030140; C:trans-Golgi network transport vesicle; IDA:ZFIN. DR GO; GO:0045494; P:photoreceptor cell maintenance; IMP:ZFIN. DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN. DR InterPro; IPR008568; EMC3. DR InterPro; IPR002809; EMC3/TMCO1. DR PANTHER; PTHR13116; PTHR13116; 1. DR Pfam; PF01956; EMC3_TMCO1; 1. DR PIRSF; PIRSF010045; DUF850_TM_euk; 1. DR SMART; SM01415; DUF106; 1. PE 2: Evidence at transcript level; KW Complete proteome; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1 261 ER membrane protein complex subunit 3. FT /FTId=PRO_0000211410. FT TRANSMEM 14 34 Helical. {ECO:0000255}. FT TRANSMEM 118 138 Helical. {ECO:0000255}. FT CONFLICT 25 25 F -> I (in Ref. 1; AAW19648). FT {ECO:0000305}. SQ SEQUENCE 261 AA; 29792 MW; EC717145BD15EEBC CRC64; MAEPELLLDS NIRLWVVLPI VFITFLVGVI RHYVSILLQS DKKLTLEQVS DSQVLIRSRV LRENGKYIPK QSFLMRKFYF NNQEDGFFKK TKRKVVPPSP MTDPSMLTDM MKGNVTNVLP MILIGGWINW TFSGFVTTKV PFPLTLRFKP MLQQGIELLS LDASWVSSAS WYFLNVFGLR SMYSLILGQD NGADQSRIMQ EQMSGAAMAM PADTNKAFKA EWEALELTDH QWALENVEED LMSKDLDLSG MFSKDLPTGI F //