ID RSM28_NEUCR Reviewed; 414 AA.
AC Q7SG49;
DT 13-SEP-2023, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Small ribosomal subunit protein mS46 {ECO:0000303|PubMed:33056988};
GN Name=rsm28; ORFNames=NCU07493;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [2] {ECO:0007744|PDB:6YW5, ECO:0007744|PDB:6YWX}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.85 ANGSTROMS).
RX PubMed=33056988; DOI=10.1038/s41467-020-18830-w;
RA Itoh Y., Naschberger A., Mortezaei N., Herrmann J.M., Amunts A.;
RT "Analysis of translating mitoribosome reveals functional characteristics of
RT translation in mitochondria of fungi.";
RL Nat. Commun. 11:5187-5187(2020).
CC -!- FUNCTION: Component of the mitochondrial ribosome (mitoribosome), a
CC dedicated translation machinery responsible for the synthesis of
CC mitochondrial genome-encoded proteins, including at least some of the
CC essential transmembrane subunits of the mitochondrial respiratory
CC chain. The mitoribosomes are attached to the mitochondrial inner
CC membrane and translation products are cotranslationally integrated into
CC the membrane. {ECO:0000305|PubMed:33056988}.
CC -!- SUBUNIT: Component of the mitochondrial small ribosomal subunit (mt-
CC SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small
CC (37S) and a large (54S) subunit. The 37S small subunit contains a 16S
CC ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large
CC subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
CC {ECO:0000269|PubMed:33056988}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33056988}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mS46 family. {ECO:0000305}.
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DR EMBL; CM002236; EAA35804.1; -; Genomic_DNA.
DR RefSeq; XP_965040.1; XM_959947.3.
DR PDB; 6YW5; EM; 2.85 A; 77=1-414.
DR PDB; 6YWX; EM; 3.10 A; 77=1-414.
DR PDBsum; 6YW5; -.
DR PDBsum; 6YWX; -.
DR AlphaFoldDB; Q7SG49; -.
DR EMDB; EMD-10958; -.
DR EMDB; EMD-10978; -.
DR SMR; Q7SG49; -.
DR STRING; 367110.Q7SG49; -.
DR PaxDb; 5141-EFNCRP00000007416; -.
DR EnsemblFungi; EAA35804; EAA35804; NCU07493.
DR GeneID; 3881189; -.
DR KEGG; ncr:NCU07493; -.
DR VEuPathDB; FungiDB:NCU07493; -.
DR HOGENOM; CLU_053748_0_0_1; -.
DR InParanoid; Q7SG49; -.
DR OMA; QHETPKF; -.
DR OrthoDB; 1778977at2759; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome.
FT CHAIN 1..414
FT /note="Small ribosomal subunit protein mS46"
FT /id="PRO_0000458565"
FT REGION 20..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 43046 MW; 272753C6EB5BC3DF CRC64;
MNRQVVTSTL GRRGVASTIL NAQQQQRPFS STTTRCAAED DSKKPAAAPS TPRAAAPGPI
SASRQKSEAA VGKLTQLRGS FTSLTNDNSF HKTLPAGARD ARRLAAAPIA GKGAGAGAVA
PLGGGGGASG APKVINVRSL KGTLGSRGSN NIPGAVAPGA ALRPRFAAGP GAAAGRPRFG
AAASPGAGPT GAARRPPFGA RRARPAGDKK RSGGSGDKRP RGDDYDAPPT EEEKAFLRGL
EQGKVTEYVP KLTPDTLLGY GPPVATDAAL GKVESAMRTM RILGGGLPFN DQSGVTSDPT
AIKHRYVHEK KPVFFSSVEE KEWVRESLDK FAVSEGPEKK TKQKILETSV LGKYEEPKYV
ESLTETVKMV EKYQGGTFSY APSDADKFNK KLNQLLAAGL PRAAPAPAQA QKKA
//