ID MRS2_NEUCR Reviewed; 547 AA. AC Q7SFQ9; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 15-DEC-2003, sequence version 1. DT 03-APR-2013, entry version 56. DE RecName: Full=Mitochondrial inner membrane magnesium transporter mrs2; DE AltName: Full=RNA-splicing protein MRS2; DE Flags: Precursor; GN Name=mrs2; ORFNames=NCU09091; OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM OS 1257 / FGSC 987). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; OC Neurospora. OX NCBI_TaxID=367110; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; RX PubMed=12712197; DOI=10.1038/nature01554; RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., RA Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., RA Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., RA Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., RA Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., RA Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., RA Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., RA Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., RA Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.; RT "The genome sequence of the filamentous fungus Neurospora crassa."; RL Nature 422:859-868(2003). CC -!- FUNCTION: Mitochondrial inner membrane magnesium transporter CC required for mitochondrial magnesium homeostasis. Involved in the CC splicing of mRNA group II introns in mitochondria by affecting CC mitochondrial magnesium concentrations, which are critical for CC group II intron splicing (By similarity). CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) CC (TC 1.A.35) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABX02000059; EAA35672.1; -; Genomic_DNA. DR RefSeq; XP_964908.1; XM_959815.1. DR UniGene; Ncr.20286; -. DR ProteinModelPortal; Q7SFQ9; -. DR STRING; 5141.NCU09091.1; -. DR EnsemblFungi; EFNCRT00000008720; EFNCRP00000008702; EFNCRG00000008706. DR GeneID; 3881059; -. DR KEGG; ncr:NCU09091; -. DR eggNOG; NOG284534; -. DR HOGENOM; HOG000202172; -. DR KO; K16075; -. DR OrthoDB; EOG432474; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB. DR GO; GO:0045016; P:mitochondrial magnesium ion transport; ISS:UniProtKB. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB. DR InterPro; IPR026573; MRS2/LPE10. DR PANTHER; PTHR13890; PTHR13890; 1. DR Pfam; PF01544; CorA; 1. PE 3: Inferred from homology; KW Complete proteome; Ion transport; Magnesium; Membrane; Mitochondrion; KW Mitochondrion inner membrane; Reference proteome; Transit peptide; KW Transmembrane; Transmembrane helix; Transport. FT TRANSIT 1 75 Mitochondrion (Potential). FT CHAIN 76 547 Mitochondrial inner membrane magnesium FT transporter mrs2. FT /FTId=PRO_0000043247. FT TRANSMEM 428 448 Helical; (Potential). FT TRANSMEM 467 487 Helical; (Potential). FT MOTIF 452 455 YGMN. SQ SEQUENCE 547 AA; 61554 MW; 41F0138ECFCF3E45 CRC64; MPPALRPAAP SRSLLRYLRA QSEGLSFAPT CRAAAERHPA LQCRHGCTAG GSTRPPRQPS SSTTTRSLST ATPPKRTQLR AGLVDLEAIL PKSLRKQRTT KSLLALPPPA GSLRFSSNQS SDCDSKRPKL REWLFGNGEK KGPPDTRLND DDIRVALEEE SGSIFQRRAL TAKAAMDPRL RCTEVDENGN VVMVDGELKK SELIAKYGLL PRDLRKIDSS NLPHILIRPS AILLNLLHLK VLIKHDCVLL FDVYGSKSSY PQSAFMYDLQ GKLQQKQSSG ANSLPYEFRA LEAVLMSVTS ELEADFEAVR DPVIRILSEL EDDIDREKLR VLLVLSKRVS TFEQKAKLVR DAIEELLEAD DDLASMYLTE KTHDLYRGED DHTEIELLLE SYNKICDEVV EEASNLVSSI RNTEEIIRAI LDANRNSLML LDLKFSVGTL GLAMGTFLAS WYGMNLENFI EETNWGFAMV TSVSTVASLI VCWYGLVKLR KVQRVKMGDL HNRNAPNHWF RDESTDVLLD PSNRERLRRI NSMKSAQQKR STSKKWF //