ID MRS2_NEUCR STANDARD; PRT; 547 AA. AC Q7SFQ9; DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 15-DEC-2003, sequence version 1. DT 25-JUL-2006, entry version 17. DE Inner membrane magnesium transporter MRS2, mitochondrial precursor DE (RNA-splicing protein MRS2). GN Name=mrs-2; ORFNames=NCU09091; OS Neurospora crassa. OC Eukaryota; Fungi; Ascomycota; Pezizomycotina; Sordariomycetes; OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora. OX NCBI_TaxID=5141; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; RX MEDLINE=22598136; PubMed=12712197; DOI=10.1038/nature01554; RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., RA Jaffe D., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., RA Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., RA Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., RA Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., RA Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., RA Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S., RA Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., RA Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., RA Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.; RT "The genome sequence of the filamentous fungus Neurospora crassa."; RL Nature 422:859-868(2003). CC -!- FUNCTION: Mitochondrial inner membrane magnesium transporter CC required for mitochondrial magnesium homeostasis. Involved in the CC splicing of mitochondrial mRNA group II introns (By similarity). CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial inner membrane; CC multi-pass membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the corA metal ion transporter (MIT) CC (TC 1.A.35) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABX01000017; EAA35672.1; -; Genomic_DNA. DR InterPro; IPR002523; Mg2+_transptCorA. DR Pfam; PF01544; CorA; 1. KW Inner membrane; Ion transport; Magnesium; Membrane; Mitochondrion; KW mRNA processing; mRNA splicing; Transit peptide; Transmembrane; KW Transport. FT TRANSIT 1 75 Mitochondrion (Potential). FT CHAIN 76 547 Inner membrane magnesium transporter FT MRS2. FT /FTId=PRO_0000043247. FT TRANSMEM 428 448 Potential. FT TRANSMEM 467 487 Potential. FT MOTIF 452 455 YGMN. SQ SEQUENCE 547 AA; 61554 MW; 41F0138ECFCF3E45 CRC64; MPPALRPAAP SRSLLRYLRA QSEGLSFAPT CRAAAERHPA LQCRHGCTAG GSTRPPRQPS SSTTTRSLST ATPPKRTQLR AGLVDLEAIL PKSLRKQRTT KSLLALPPPA GSLRFSSNQS SDCDSKRPKL REWLFGNGEK KGPPDTRLND DDIRVALEEE SGSIFQRRAL TAKAAMDPRL RCTEVDENGN VVMVDGELKK SELIAKYGLL PRDLRKIDSS NLPHILIRPS AILLNLLHLK VLIKHDCVLL FDVYGSKSSY PQSAFMYDLQ GKLQQKQSSG ANSLPYEFRA LEAVLMSVTS ELEADFEAVR DPVIRILSEL EDDIDREKLR VLLVLSKRVS TFEQKAKLVR DAIEELLEAD DDLASMYLTE KTHDLYRGED DHTEIELLLE SYNKICDEVV EEASNLVSSI RNTEEIIRAI LDANRNSLML LDLKFSVGTL GLAMGTFLAS WYGMNLENFI EETNWGFAMV TSVSTVASLI VCWYGLVKLR KVQRVKMGDL HNRNAPNHWF RDESTDVLLD PSNRERLRRI NSMKSAQQKR STSKKWF //