ID RM35_NEUCR Reviewed; 449 AA. AC Q7RXV8; DT 13-SEP-2023, integrated into UniProtKB/Swiss-Prot. DT 23-OCT-2007, sequence version 2. DT 24-JUL-2024, entry version 91. DE RecName: Full=Large ribosomal subunit protein mL38 {ECO:0000303|PubMed:33056988}; GN Name=mrpl35; ORFNames=NCU01473; OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / OS FGSC 987). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora. OX NCBI_TaxID=367110; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; RX PubMed=12712197; DOI=10.1038/nature01554; RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.; RT "The genome sequence of the filamentous fungus Neurospora crassa."; RL Nature 422:859-868(2003). RN [2] RP IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, AND RP IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=16451194; DOI=10.1111/j.1574-6968.2005.00024.x; RA Gan X., Arita K., Isono S., Kitakawa M., Yoshino K., Yonezawa K., Kato A., RA Inoue H., Isono K.; RT "Identification and comparative analysis of the large subunit mitochondrial RT ribosomal proteins of Neurospora crassa."; RL FEMS Microbiol. Lett. 254:157-164(2006). RN [3] {ECO:0007744|PDB:6YWS, ECO:0007744|PDB:6YWV} RP STRUCTURE BY ELECTRON MICROSCOPY (2.74 ANGSTROMS). RX PubMed=33056988; DOI=10.1038/s41467-020-18830-w; RA Itoh Y., Naschberger A., Mortezaei N., Herrmann J.M., Amunts A.; RT "Analysis of translating mitoribosome reveals functional characteristics of RT translation in mitochondria of fungi."; RL Nat. Commun. 11:5187-5187(2020). CC -!- FUNCTION: Component of the mitochondrial ribosome (mitoribosome), a CC dedicated translation machinery responsible for the synthesis of CC mitochondrial genome-encoded proteins, including at least some of the CC essential transmembrane subunits of the mitochondrial respiratory CC chain. The mitoribosomes are attached to the mitochondrial inner CC membrane and translation products are cotranslationally integrated into CC the membrane. {ECO:0000305|PubMed:33056988}. CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt- CC LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small CC (37S) and a large (54S) subunit. The 37S small subunit contains a 16S CC ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large CC subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. CC {ECO:0000269|PubMed:16451194, ECO:0000269|PubMed:33056988}. CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16451194, CC ECO:0000269|PubMed:33056988}. CC -!- SIMILARITY: Belongs to the phosphatidylethanolamine-binding protein CC family. Mitochondrion-specific ribosomal protein mL38 subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CM002240; EAA27514.2; -; Genomic_DNA. DR RefSeq; XP_956750.2; XM_951657.3. DR PDB; 6YWS; EM; 2.74 A; 1=1-449. DR PDB; 6YWV; EM; 3.03 A; 1=1-449. DR PDB; 6YWX; EM; 3.10 A; 1=1-449. DR PDBsum; 6YWS; -. DR PDBsum; 6YWV; -. DR PDBsum; 6YWX; -. DR AlphaFoldDB; Q7RXV8; -. DR EMDB; EMD-10973; -. DR EMDB; EMD-10977; -. DR EMDB; EMD-10978; -. DR SMR; Q7RXV8; -. DR STRING; 367110.Q7RXV8; -. DR PaxDb; 5141-EFNCRP00000007595; -. DR EnsemblFungi; EAA27514; EAA27514; NCU01473. DR GeneID; 3872898; -. DR KEGG; ncr:NCU01473; -. DR VEuPathDB; FungiDB:NCU01473; -. DR HOGENOM; CLU_035836_0_0_1; -. DR InParanoid; Q7RXV8; -. DR OMA; FRTQWDE; -. DR OrthoDB; 2724293at2759; -. DR Proteomes; UP000001805; Chromosome 2, Linkage Group V. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. DR CDD; cd00866; PEBP_euk; 1. DR Gene3D; 1.20.58.1180; -; 1. DR Gene3D; 3.90.280.10; PEBP-like; 1. DR InterPro; IPR008914; PEBP. DR InterPro; IPR036610; PEBP-like_sf. DR InterPro; IPR035810; PEBP_euk. DR PANTHER; PTHR11362:SF133; 39S RIBOSOMAL PROTEIN L38, MITOCHONDRIAL; 1. DR PANTHER; PTHR11362; PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN; 1. DR Pfam; PF01161; PBP; 1. DR SUPFAM; SSF49777; PEBP-like; 1. PE 1: Evidence at protein level; KW 3D-structure; Mitochondrion; Reference proteome. FT CHAIN 1..449 FT /note="Large ribosomal subunit protein mL38" FT /id="PRO_0000458628" FT REGION 37..72 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 44..69 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 449 AA; 50666 MW; 8A94DA57F1CA64E4 CRC64; MSTCQQVARP LVRCLRQTGP GAATCSTRSV AVAAVRPFSS TPMRKEEGAT TTTTTSPVDS TTTPPPLPSA TEAKATVADT VVGGPELGSR RRRAALATTG NLPFEQLPYQ CFQDARKILQ QDRAAKIAQI VKETEKIKLI EARDASEFEG GEAAKQTRIK SLRKYIEELK ILADINDPEV KRRFEDGRGD MTKPVYRFMA ERRWRSMDYK IIAQRISQFH VVPDLLPAFD PTMDVKLSFR GYQVSPGAIL DSRVTEVAPT LRMQVFDKGE RLLTVVVIDS DVPDVTHDNF KRRCHFLAAN IPWDPSKTVL SLRSVGDRVE GDVGKPWLPP FAQKGSPYHR LNVFVLEQKP GAKIDGEALK KHLENRENFS LKGFREKFDL EPVGFNLFRS EWDEGTAEVM ERHGIPGAEV EFKRQKFASL KPPRKARGWE AKRQKPKYKS LWKYVKRIA //