ID Q7RTW4_HUMAN Unreviewed; 645 AA. AC Q7RTW4; DT 15-DEC-2003, integrated into UniProtKB/TrEMBL. DT 15-DEC-2003, sequence version 1. DT 26-FEB-2008, entry version 30. DE Neuregulin 1 isoform HRG-beta1 (Neuregulin 1, isoform CRA_i). GN Name=NRG1; ORFNames=hCG_14780; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=12145742; DOI=10.1086/342734; RA Stefansson H., Sigurdsson E., Steinthorsdottir V., Bjornsdottir S., RA Sigmundsson T., Ghosh S., Brynjolfsson J., Gunnarsdottir S., RA Ivarsson O., Chou T.T., Hjaltason O., Birgisdottir B., Jonsson H., RA Gudnadottir V.G., Gudmundsdottir E., Bjornsson A., Ingvarsson B., RA Ingason A., Sigfusson S., Hardardottir H., Harvey R.P., Brunner D., RA Mutel V., Gonzalo A., Lemke G., Sainz J., Johannesson G., RA Andresson T., Gudbjartsson D., Manolescu A., Frigge M.L., Gurney M.E., RA Kong A., Gulcher J.R., Petursson H., Stefansson K.; RT "Neuregulin 1 and susceptibility to Schizophrenia."; RL Am. J. Hum. Genet. 71:877-892(2002). RN [2] RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BK000383; DAA00041.1; -; Genomic_DNA. DR EMBL; CH471080; EAW63415.1; -; Genomic_DNA. DR UniGene; Hs.453951; -. DR HSSP; Q12780; 1HRE. DR SMR; Q7RTW4; 175-241. DR Ensembl; ENSG00000157168; Homo sapiens. DR HGNC; HGNC:7997; NRG1. DR ArrayExpress; Q7RTW4; -. DR GO; GO:0005102; F:receptor binding; IEA:InterPro. DR GO; GO:0009790; P:embryonic development; IEA:InterPro. DR InterPro; IPR006210; EGF. DR InterPro; IPR000742; EGF_3. DR InterPro; IPR006209; EGF_like. DR InterPro; IPR013032; EGF_like_reg_CS. DR InterPro; IPR013151; Ig. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR002154; Neuregulin_1_C. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF02158; Neuregulin; 1. DR PRINTS; PR01089; NEUREGULIN. DR SMART; SM00181; EGF; 1. DR SMART; SM00408; IGc2; 1. DR PROSITE; PS00022; EGF_1; UNKNOWN_1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW EGF-like domain; Immunoglobulin domain. SQ SEQUENCE 645 AA; 71127 MW; 04B7AFF528CDD628 CRC64; MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQKRVLT ITGICIALLV VGIMCVVAYC KTKKQRKKLH DRLRQSLRSE RNNTMNIANG PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REAETSFSTS HYTSTAHHST TVTQTPSHSW SNGHTESILS ESHSVIVMSS VENSRHSSPT GGPRGRLNGT GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP KSPPSEMSPP VSSMTVSMPS MAVSPFMEEE RPLLLVTPPR LREKKFDHHP QQFSSFHHNP AHDSNSLPAS PLRIVEDEEY ETTQEYEPAQ EPVKKLANSR RAKRTKPNGH IANRLEVDSN TSSQSSNSES ETEDERVGED TPFLGIQNPL AASLEATPAF RLADSRTNPA GRFSTQEEIQ ARLSSVIANQ DPIAV //