ID Q7RTW4_HUMAN PRELIMINARY; PRT; 645 AA. AC Q7RTW4; DT 15-DEC-2003, integrated into UniProtKB/TrEMBL. DT 15-DEC-2003, sequence version 1. DT 04-APR-2006, entry version 13. DE Neuregulin 1 isoform HRG-beta1. GN Name=NRG1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22233215; PubMed=12145742; RA Stefansson H., Sigurdsson E., Steinthorsdottir V., Bjornsdottir S., RA Sigmundsson T., Ghosh S., Brynjolfsson J., Gunnarsdottir S., RA Ivarsson O., Chou T.T., Hjaltason O., Birgisdottir B., Jonsson H., RA Gudnadottir V.G., Gudmundsdottir E., Bjornsson A., Ingvarsson B., RA Ingason A., Sigfusson S., Hardardottir H., Harvey R.P., Brunner D., RA Mutel V., Gonzalo A., Lemke G., Sainz J., Johannesson G., RA Andresson T., Gudbjartsson D., Manolescu A., Frigge M.L., Gurney M.E., RA Kong A., Gulcher J.R., Petursson H., Stefansson K.; RT "Neuregulin 1 and susceptibility to Schizophrenia."; RL Am. J. Hum. Genet. 71:877-892(2002). CC -!- MISCELLANEOUS: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ third party annotation (TPA) entry. CC -!- DOMAIN: ERBB receptor binding is elicited entirely by the EGF-like CC domain (By similarity). CC -!- DOMAIN: The cytoplasmic domain may be involved in the regulation CC of trafficking and proteolytic processing. Regulation of the CC proteolytic processing involves initial intracellular domain CC dimerization (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BK000383; DAA00041.1; -; Genomic_DNA. DR HSSP; Q12780; 1HRE. DR SMR; Q7RTW4; 175-241. DR Ensembl; ENSG00000157168; Homo sapiens. DR GO; GO:0005102; F:receptor binding; IEA. DR GO; GO:0009790; P:embryonic development; IEA. DR InterPro; IPR006210; EGF. DR InterPro; IPR000742; EGF_3. DR InterPro; IPR006209; EGF_like. DR InterPro; IPR013032; EGF_like_reg. DR InterPro; IPR003599; Ig. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003598; Ig_c2. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR002154; Neuregulin_1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF02158; Neuregulin; 1. DR PRINTS; PR01089; NEUREGULIN. DR SMART; SM00181; EGF; 1. DR SMART; SM00409; IG; 1. DR SMART; SM00408; IGc2; 1. DR PROSITE; PS00022; EGF_1; UNKNOWN_1. DR PROSITE; PS50026; EGF_3; 1. DR PROSITE; PS50835; IG_LIKE; 1. KW EGF-like domain; Growth factor; Immunoglobulin domain; Membrane; KW Transmembrane. SQ SEQUENCE 645 AA; 71127 MW; 04B7AFF528CDD628 CRC64; MSERKEGRGK GKGKKKERGS GKKPESAAGS QSPALPPRLK EMKSQESAAG SKLVLRCETS SEYSSLRFKW FKNGNELNRK NKPQNIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN DSASANITIV ESNEIITGMP ASTEGAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLV KCAEKEKTFC VNGGECFMVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQKRVLT ITGICIALLV VGIMCVVAYC KTKKQRKKLH DRLRQSLRSE RNNTMNIANG PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REAETSFSTS HYTSTAHHST TVTQTPSHSW SNGHTESILS ESHSVIVMSS VENSRHSSPT GGPRGRLNGT GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP KSPPSEMSPP VSSMTVSMPS MAVSPFMEEE RPLLLVTPPR LREKKFDHHP QQFSSFHHNP AHDSNSLPAS PLRIVEDEEY ETTQEYEPAQ EPVKKLANSR RAKRTKPNGH IANRLEVDSN TSSQSSNSES ETEDERVGED TPFLGIQNPL AASLEATPAF RLADSRTNPA GRFSTQEEIQ ARLSSVIANQ DPIAV //