ID ZN367_HUMAN Reviewed; 350 AA. AC Q7RTV3; Q6Q7C8; DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 15-DEC-2003, sequence version 1. DT 12-SEP-2018, entry version 126. DE RecName: Full=Zinc finger protein 367; DE AltName: Full=C2H2 zinc finger protein ZFF29; GN Name=ZNF367; Synonyms=ZFF29; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR RP LOCATION, AND ALTERNATIVE SPLICING. RC TISSUE=Fetal liver; RX PubMed=15344908; DOI=10.1042/BJ20040394; RA Asano H., Murate T., Naoe T., Saito H., Stamatoyannopoulos G.; RT "Molecular cloning and characterization of ZFF29: a protein containing RT a unique Cys2His2 zinc-finger motif."; RL Biochem. J. 384:647-653(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION (ISOFORM 1). RX PubMed=12234665; DOI=10.1016/S0378-1119(02)00793-X; RA Gilligan P., Brenner S., Venkatesh B.; RT "Fugu and human sequence comparison identifies novel human genes and RT conserved non-coding sequences."; RL Gene 294:35-44(2002). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND IDENTIFICATION RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- FUNCTION: Transcriptional activator. Isoform 1 may be involved in CC transcriptional activation of erythroid genes. CC {ECO:0000269|PubMed:15344908}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15344908}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=ZFF29B; CC IsoId=Q7RTV3-1; Sequence=Displayed; CC Name=2; Synonyms=ZFF29A; CC IsoId=Q7RTV3-2; Sequence=VSP_024865; CC Note=No experimental confirmation available.; CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY554164; AAS66302.1; -; mRNA. DR EMBL; AY554165; AAS66303.1; -; mRNA. DR EMBL; AL133477; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC126141; AAI26142.1; -; mRNA. DR EMBL; BK000211; DAA00067.1; -; mRNA. DR CCDS; CCDS6718.1; -. [Q7RTV3-1] DR RefSeq; NP_710162.1; NM_153695.3. [Q7RTV3-1] DR UniGene; Hs.494557; -. DR ProteinModelPortal; Q7RTV3; -. DR SMR; Q7RTV3; -. DR STRING; 9606.ENSP00000364405; -. DR iPTMnet; Q7RTV3; -. DR PhosphoSitePlus; Q7RTV3; -. DR BioMuta; ZNF367; -. DR DMDM; 74762420; -. DR MaxQB; Q7RTV3; -. DR PaxDb; Q7RTV3; -. DR PeptideAtlas; Q7RTV3; -. DR PRIDE; Q7RTV3; -. DR ProteomicsDB; 68913; -. DR ProteomicsDB; 68914; -. [Q7RTV3-2] DR Ensembl; ENST00000375256; ENSP00000364405; ENSG00000165244. [Q7RTV3-1] DR GeneID; 195828; -. DR KEGG; hsa:195828; -. DR UCSC; uc004awf.4; human. [Q7RTV3-1] DR CTD; 195828; -. DR DisGeNET; 195828; -. DR EuPathDB; HostDB:ENSG00000165244.6; -. DR GeneCards; ZNF367; -. DR HGNC; HGNC:18320; ZNF367. DR HPA; HPA015319; -. DR HPA; HPA015785; -. DR MIM; 610160; gene. DR neXtProt; NX_Q7RTV3; -. DR OpenTargets; ENSG00000165244; -. DR PharmGKB; PA38316; -. DR eggNOG; KOG1721; Eukaryota. DR eggNOG; COG5048; LUCA. DR GeneTree; ENSGT00670000098074; -. DR HOGENOM; HOG000049286; -. DR HOVERGEN; HBG061619; -. DR InParanoid; Q7RTV3; -. DR OMA; LAKYWEM; -. DR OrthoDB; EOG091G0H1R; -. DR PhylomeDB; Q7RTV3; -. DR TreeFam; TF321334; -. DR GenomeRNAi; 195828; -. DR PRO; PR:Q7RTV3; -. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000165244; Expressed in 150 organ(s), highest expression level in heart. DR CleanEx; HS_ZNF367; -. DR Genevisible; Q7RTV3; HS. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR SMART; SM00355; ZnF_C2H2; 2. DR SUPFAM; SSF57667; SSF57667; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2. PE 1: Evidence at protein level; KW Activator; Alternative splicing; Coiled coil; Complete proteome; KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; KW Reference proteome; Repeat; Transcription; Transcription regulation; KW Zinc; Zinc-finger. FT CHAIN 1 350 Zinc finger protein 367. FT /FTId=PRO_0000285297. FT ZN_FING 167 189 C2H2-type 1. {ECO:0000255|PROSITE- FT ProRule:PRU00042}. FT ZN_FING 195 219 C2H2-type 2. {ECO:0000255|PROSITE- FT ProRule:PRU00042}. FT COILED 308 342 {ECO:0000255}. FT COMPBIAS 8 61 Pro-rich. FT COMPBIAS 86 122 Ala-rich. FT MOD_RES 310 310 Phosphoserine. FT {ECO:0000244|PubMed:18669648, FT ECO:0000244|PubMed:23186163}. FT VAR_SEQ 278 350 YWEMREQRTPTLKGKLVQKADQEQQDPLEYLQSDEEDDEKR FT GAQRRLQEQRERLHGALALIELANLTGAPLRQ -> SGMLP FT LVHREDAQRGLGLCQGPGHASHFK (in isoform 2). FT {ECO:0000303|PubMed:15344908}. FT /FTId=VSP_024865. SQ SEQUENCE 350 AA; 38411 MW; 01C3A79E0E408454 CRC64; MIRGFEAPMA ENPPPPPPPV IFCHDSPKRV LVSVIRTTPI KPTCGGGGEP EPPPPLIPTS PGFSDFMVYP WRWGENAHNV TLSPGAAGAA ASAALPAAAA AEHSGLRGRG APPPAASASA AASGGEDEEE ASSPDSGHLK DGIRRGRPRA DTVRDLINEG EHSSSRIRCN ICNRVFPREK SLQAHKRTHT GERPYLCDYP DCGKAFVQSG QLKTHQRLHT GEKPFVCSEN GCLSRFTHAN RHCPKHPYAR LKREEPTDTL SKHQAADNKA AAEWLARYWE MREQRTPTLK GKLVQKADQE QQDPLEYLQS DEEDDEKRGA QRRLQEQRER LHGALALIEL ANLTGAPLRQ //