ID TR120_MOUSE Reviewed; 295 AA. AC Q7M721; DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot. DT 15-DEC-2003, sequence version 1. DT 22-FEB-2023, entry version 118. DE RecName: Full=Taste receptor type 2 member 120; DE Short=T2R120; DE Short=mT2R47; GN Name=Tas2r120 {ECO:0000312|MGI:MGI:2681256}; GN Synonyms=T2r47 {ECO:0000303|PubMed:12679530}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000305} RP PROTEIN SEQUENCE OF 282-294, AND IDENTIFICATION BY MASS SPECTROMETRY. RC STRAIN=OF1; TISSUE=Hippocampus; RA Lubec G., Sunyer B., Chen W.-Q.; RL Submitted (JAN-2009) to UniProtKB. RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01215.1} RP IDENTIFICATION. RX PubMed=12679530; DOI=10.1093/molbev/msg083; RA Shi P., Zhang J., Yang H., Zhang Y.-P.; RT "Adaptive diversification of bitter taste receptor genes in mammalian RT evolution."; RL Mol. Biol. Evol. 20:805-814(2003). CC -!- FUNCTION: Putative taste receptor which may play a role in the CC perception of bitterness. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single CC taste receptor cell. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family. CC {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BK001076; DAA01215.1; -; Genomic_DNA. DR CCDS; CCDS20617.1; -. DR RefSeq; NP_996906.1; NM_207023.1. DR AlphaFoldDB; Q7M721; -. DR SMR; Q7M721; -. DR STRING; 10090.ENSMUSP00000071626; -. DR GlyCosmos; Q7M721; 1 site, No reported glycans. DR GlyGen; Q7M721; 1 site. DR iPTMnet; Q7M721; -. DR PhosphoSitePlus; Q7M721; -. DR PaxDb; Q7M721; -. DR DNASU; 387348; -. DR Ensembl; ENSMUST00000071707.3; ENSMUSP00000071626.2; ENSMUSG00000059382.3. DR GeneID; 387348; -. DR KEGG; mmu:387348; -. DR UCSC; uc009eji.1; mouse. DR AGR; MGI:2681256; -. DR CTD; 387348; -. DR MGI; MGI:2681256; Tas2r120. DR VEuPathDB; HostDB:ENSMUSG00000059382; -. DR eggNOG; ENOG502TE6U; Eukaryota. DR GeneTree; ENSGT01060000248524; -. DR HOGENOM; CLU_072337_2_0_1; -. DR InParanoid; Q7M721; -. DR OMA; FCQAIIF; -. DR OrthoDB; 5306466at2759; -. DR PhylomeDB; Q7M721; -. DR TreeFam; TF335891; -. DR Reactome; R-MMU-418594; G alpha (i) signalling events. DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors). DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste. DR BioGRID-ORCS; 387348; 2 hits in 76 CRISPR screens. DR PRO; PR:Q7M721; -. DR Proteomes; UP000000589; Chromosome 6. DR RNAct; Q7M721; protein. DR GO; GO:0016020; C:membrane; ISO:MGI. DR GO; GO:0031514; C:motile cilium; ISO:MGI. DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0008527; F:taste receptor activity; ISO:MGI. DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI. DR CDD; cd15027; 7tm_TAS2R43-like; 1. DR InterPro; IPR007960; TAS2R. DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1. DR PANTHER; PTHR11394:SF27; TASTE RECEPTOR TYPE 2 MEMBER 20; 1. DR Pfam; PF05296; TAS2R; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Sensory transduction; Taste; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..295 FT /note="Taste receptor type 2 member 120" FT /id="PRO_0000248479" FT TOPO_DOM 1..5 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 6..26 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 27..45 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 46..66 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 67..80 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 81..101 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 102..127 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 128..148 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 149..177 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 178..198 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 199..228 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 229..249 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 250..255 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 256..276 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 277..295 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 160 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 295 AA; 33594 MW; 8E2D6847B7AA4431 CRC64; MNLVEWIVTI IMMTEFLLGN CANVFITIVN FIDCVKRRKI SSADRIITAI AIFRIGLLWA MLTNWHSHVF TPDTDNLQMR VFGGITWAIT NHFTTWLGTI LSMFYLFKIA NFSNSLFLHL KRKLDNVLLV IFLGSSLFLV AYLGMVNIKK IAWMSIHEGN VTTKSKLKHV TSITNMLLFS LINIVPFGIS LNCVLLLIYS LSKHLKNMKF YGKGCQDQST MVHIKALQTV VSFLLLYATY SSCVIISGWS LQNAPVFLFC VTIGSFYPAG HSCILIWGNQ KLKQVFLLLL RQMRC //